EGIS-8332 - CAS 220725-87-1
Catalog number: 220725-87-1
Category: Inhibitor
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Molecular Formula:
C20H18N4O3
Molecular Weight:
362.389
COA:
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Targets:
AMPAR
Description:
EGIS-8332 potently decreased AMPA and quisqualate induced LDH release (IC50 = 5.2 ± 0.4 and 7.4 ± 1.3 μM, respectively) from the cells. The inhibition of the AMPA/kainate ion channels by EGIS-8332 is non-competitive, not use dependent, and depends neither on the closed/open state of the channel, nor the membrane potential.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
7-acetyl-5-(4-aminophenyl)-8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-8-carbonitrile; EGIS-8332; EGIS 8332; EGIS8332.
MSDS:
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InChIKey:
CBHCOCUJJQDHSR-UHFFFAOYSA-N
InChI:
1S/C20H18N4O3/c1-12(25)24-20(2,10-21)9-14-7-17-18(27-11-26-17)8-16(14)19(23-24)13-3-5-15(22)6-4-13/h3-8H,9,11,22H2,1-2H3
Canonical SMILES:
CC(=O)N1C(CC2=CC3=C(C=C2C(=N1)C4=CC=C(C=C4)N)OCO3)(C)C#N
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