EGF816 mesylate - CAS 1508250-72-3
Catalog number: 1508250-72-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H35ClN6O5S
Molecular Weight:
591.12
COA:
Inquire
Targets:
EGFR
Description:
EGF816 mesylate is the mesylate salt of EGF816 which is a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M.
Publictions citing BOC Sciences Products
  • >> More
Appearance:
White to off-white solid
Synonyms:
N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide;methanesulfonic acid
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -46℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Grams-Kilos
InChIKey:
BJRYTAMUVASSBY-ZJULCNDBSA-N
InChI:
1S/C26H31ClN6O2.CH4O3S/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3;1-5(2,3)4/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35);1H3,(H,2,3,4)/b11-7+;/t20-;/m1./s1
Canonical SMILES:
CC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2C4CCCCN(C4)C(=O)C=CCN(C)C)C(=CC=C3)Cl.CS(=O)(=O)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related EGFR Products


CAS 848133-17-5 HKI 357

HKI 357
(CAS: 848133-17-5)

HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proli...

CAS 1421373-65-0 AZD-9291

AZD-9291
(CAS: 1421373-65-0)

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become ...

CAS 1110813-31-4 Dacomitinib

Dacomitinib
(CAS: 1110813-31-4)

Dacomitinib, aslo known as PF-299 and PF-00299804; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the p...

AZ5104
(CAS: 1421373-98-9)

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of

PF-06747775
(CAS: 1776112-90-3)

PF-06747775, a methylpurin derivative, has been found to be an epidermal growth factor receptor antagonist and could probably be effective against cell lung can...

CAS 122520-85-8 AG 99

AG 99
(CAS: 122520-85-8)

AG 99, an EGF receptor tyrosine kinase inhibitor, has been found to show activities in diagnosis, prevention and treatment of cancer.

CAS 1375465-09-0 CNX-2006

CNX-2006
(CAS: 1375465-09-0)

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring t...

CAS 1216920-18-1 BIBX 1382 dihydrochloride

BIBX 1382 dihydrochloride
(CAS: 1216920-18-1)

BIBX 1382 dihydrochloride is a potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with > 1000-fold lower po...

Tarloxotinib bromide
(CAS: 1636180-98-7)

Tarloxotinib bromide, a pyridopyrimidine derivative, has been found to be a EGFR tyrosine kinase inhibitor precursor and could probably be effective in antineop...

CAS 136831-49-7 RG14620

RG14620
(CAS: 136831-49-7)

RG14620 is a non-phenolic tyrphostin-class epidermal growth factor receptor (EGFR) inhibitor (IC50= 3 μM for HER 14 colony formation, and IC50= 1 pM for HER 14 ...

CAS 1173023-85-2 GW 583340 dihydrochloride

GW 583340 dihydrochloride
(CAS: 1173023-85-2)

GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 = 0.01 and 0.014 μM, respectively). GW 583340 selectively inhibits growth ...

CAS 248594-19-6 Erlotinib mesylate

Erlotinib mesylate
(CAS: 248594-19-6)

Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth ...

CAS 1353550-13-6 Olmutinib

Olmutinib
(CAS: 1353550-13-6)

Olmutinib, also called as HM61713 and BI-1482694, is an orally available, mutant-selective third-generation epidermal growth factor receptor tyrosine kinase inh...

CAS 848942-61-0 AZD-8931

AZD-8931
(CAS: 848942-61-0)

Sapitinib, also known as AZD-8931, is an erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. AZD8931 binds to and inhibits erbB tyro...

CAS 879127-07-8 EGFR Inhibitor

EGFR Inhibitor
(CAS: 879127-07-8)

A cell-permeable and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nanomolar range. Inhibition of EGFR induces apoptosis of tumor cells...

CAS 1204313-51-8 Icotinib Hydrochloride

Icotinib Hydrochloride
(CAS: 1204313-51-8)

Icotinib Hydrochloride is a quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), which is upregulated in a variety of cancer cell types. Icot...

CAS 183320-51-6 OSI-420

OSI-420
(CAS: 183320-51-6)

OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of ...

CAS 184475-55-6 Gefitinib hydrochloride

Gefitinib hydrochloride
(CAS: 184475-55-6)

Gefitinib Hcl(ZD-1839 Hcl) is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.

CAS 133550-37-5 Tyrphostin B44, (+) enantiomer

Tyrphostin B44, (+) enantiomer
(CAS: 133550-37-5)

Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.86 μM). Less active than the (-) enantiomer.

CAS 1214265-57-2 WZ-8040

WZ-8040
(CAS: 1214265-57-2)

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, ...

Quick Inquiry

Verification code

Featured Items