EGF816 - CAS 1508250-71-2
Catalog number:
1508250-71-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H31ClN6O2
Molecular Weight:
495.02
COA:
Inquire
Targets:
EGFR
Description:
EGF816, also called as Nazartinib, a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M resistance mutation while sparing wild-type EGFR. in vivo: demonstrated strong tumor regressions in several EGFR activating and resistant tumor m
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Appearance:
Solid powder
Synonyms:
N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide EGF816 UNII-KE7K32EME8 KE7K32EME8 EGF-816 1508250-71-2 GTPL9204 SCHEMBL16767232 SCHEMBL16767240 EGF 816 compound 47 [PMID: 27433829]
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -45℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Grams-Kilos
Density:
1.28±0.1 g/cm3
InChIKey:
IOMMMLWIABWRKL-WUTDNEBXSA-N
InChI:
1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1
Canonical SMILES:
CC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2C4CCCCN(C4)C(=O)C=CCN(C)C)C(=CC=C3)Cl
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