|Targets||Amyloid-β | Apoptosis Inducer | β-secretase|
|Description||EGCG, also called Epigallocatechin gallate, under the IUPAC name [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate, an antioxidant extracted from green tea, reduces Aβ42-induced cell death in three different cell types and inhibits β-secretase (IC50 = 1.6 μM).|
|Brife Description||Inhibits formation of amyloid fibrils; Inhibits β-secretase (IC50 = 1.6 μM)|
|Synonyms||EGCG cpd; epigallo-catechin gallate; epigallocatechin gallate; epigallocatechin-3-gallate; epigallocatechin-3-O-gallate; EGCG; 989-51-5; Tea catechin; Teavigo; Catechin deriv.; (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate; (-)-EGCG; CCRIS 3729; CHEBI:4806; CHEMBL297453; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate; MFCD00075940; DSSTox_CID_567; DSSTox_RID_78830; DSSTox_GSID_29889; [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate; (-)-cis-3,3',4',5,5',7-Hexahydroxy-flavane-3-gallate; polyphenols; Sunphenon; C22H18O11; (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate; [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate; (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate); CAS-989-51-5; SMR000449288; (− )-cis-3,3',4',5,5',7-Hexahydroxy-flavane-3-gallate; C09731; W-5069; I14-7747; Q-100914; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxyb enzoate; [5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 2,3,4-trihydroxybenzoate; (-)-cis-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2H)-benzopyran-3-yl Gallate; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate; (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl-3,4,5-trihydroxybenzoate; 3,4-Dihydro-5,7-dihydroxy-2R-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3R-yl-3,4,5-trihydroxybenzoate; 863-65-0; Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester; Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, (2R-cis)-; Teavigo; 2kdh; 3oob|
|Solubility||Soluble to 10 mM in water and to 100 mM in ethanol|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -54℃ for long term (months to years).|
|Boiling Point||909.1°C at 760 mmHg|
Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation.
Amyloid β-Peptide (12-28) (human)
Amyloid β-Peptide (12-28) (human), an Amyloid β-peptide fragment, binds with high affinity to α7-nicotinic ACh receptors. in vivo: Impairs memory retention foll...
FLI-06 , a Notch inhibitor that disrupts Notch trafficking and processing, disrupts the Golgi by mechanisms different from BFA or GCA. It Reduces amyloid β secr...
VTP-37948, also called BI 1181181, being clinically developed with Boehringer Ingelheim and Vitae Pharmaceuticals, is a is an inhibitor targeted to the catalyti...
LY2811376, under the IUPAC name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, is the first orally available non-peptidi...
LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-β. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used ...
AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's dise...
Lanabecestat, also referred to AZD3293,is an orally active and highly permeable potent inhibitor of human β-secretase 1 in clinical development for the treatmen...
This active molecular is a potent BACE1 inhibitor that is a potential target for the treatment of Alzheimer's disease. AMG-8718 produced significantly reduction...
CEP-1612, a dipeptidyl proteasome inhibitor, induces apoptosis and inhibits tumor growth of the human lung cancer cell line A-549 in an in vivo model.
AZD3293, a spiro compound, has been found to be a β-secretase inhibitor that has good blood-brain barrier penetration and could probably be significant in studi...
Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic...
AZD3839, also called CHEMBL2177913, as a a potent BACE1 inhibitor it is a clinical candidate for the treatment of Alzheimer's disease. Studies indicate that the...
Adarotene is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. The anti-tumour activity of the co...
AZD3839, with the potential to treat Alzheimer’s disease, was reported as a selective BACE1 inhibitor (IC50=4.8μM) for which concentration-dependent lowering of...
3,3’-Diindolylmethane is a derivative of a phytochemical natural compound found in Brassicaceae(Indole-3-carbinol).It is works as an activator of Chk2 that caus...
gamma-Secretase Modulators, as a potent modulator of γ-secretase, it is derived from oxadiazine. IC50: Aβ42=11 nM, Aβtotal/ Aβ42=1170.