|Description||Eflornithine is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells.|
|Synonyms||CPP-1X, 2-difluoromethylornithine; alpha-difluoromethylornithine; difluromethylornithine;|
|Current Developer||Cancer Prevention Pharmaceuticals.|
6-O-α-D-Maltosyl-β-cyclodextrin is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol and is much less cytotoxic to human...
Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.
Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng. It is a potent anti-inflammatory and anticancer drug and exhibits antib...
Brassinolide is a plant sterol first isolated from pollen of rape (Brassica napus L.). It could promote stem elongation and cell division.
YE 120 is a GPR35 agonist (EC50 = 32 nM in DMR assays), and also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM).
Cefovecin Sodium is an antibiotic of the cephalosporin class. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphy...
QL9 (QLSPFPFDL), derived from the enzyme 2-oxoglutarate dehydrogenase, is a high-affinity alloantigen for the 2C T cell receptor (TCR).
L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, res...
GYKI-13380is a bio-active compound. But no detailed information has been published ye
5,7-Diiodo-8-Quinolinol is a topical therapeutic agent with satisfactory antibacterial properties. It is poorly absorbed from the gastrointestinal tract and is ...
Berubicin hydrochloride is hydrochloride salt of the anthracycline derivative berubicin as a topoisomerase II inhibitor with activity in ependymoma.
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This active molecular is a synthetic glucocorticoid with immunosuppressive and anti-inflammatory properties. Hydrocortamate hydrochloride is applicated for the ...
Carnitine regulates fatty acid transport in mitochondria, elevates serum carnitine fractions.
Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis.
5-Aminolevulinic acid hydrochloride
5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. 5-Aminolevulinic acid is used as a p...
SCH 202676 hydrobromide
SCH 202676 hydrobromide is a reversible inhibitor of agonist and antagonist binding to G-protein-coupled receptors. It inhibits a variety of GPCRs including ade...
DREADD agonist 21
DREADD agonist 21 has been found to be an agonist of hM3Dq with high selectivity.
SSM 3 trifluoroacetate
SSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM) which blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro...
Epimedin A, a flavonoids natural product extracted from Herbal Epimedium, could increase cardiovascular blood flow, promote hematopoietic function and has poten...