|Description||synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. One use for efaproxiral is to increase the efficacy of certain chemotherapy drugs which have reduced efficacy against hypoxic tumours, and can thus be made more effective by increased offloading of oxygen into the tumour tissues. However, no benefit was seen for efaproxiral in phase III clinical trials.|
|Current Developer||Allos Therapeutics|
A selective COX-2 inhibitor; GPR35 activator; Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 µM (human); GPR35: IC50 = 1.28 µM (human)
OTX008, a calixarene derivative, is a galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. In vitro, OTX008 effects in a p...
Glybuzole, a benzenesulfonamide derivative, has been found to have antihyperglycemic through stimulating the release of insulin.
OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming proces...
5'-Isobutylthio-5'-deoxyadenosine acts as a selectively spermine with IC50=8 uM.
trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-meth...
PD 130908 is an effective hypoxic cytotoxin as an analogue of RSU 1069, but less potent than the hypoxic cell radiosensitizer RSU 1069. Toxicity toward hypoxic ...
HI TOPK 032
HI TOPK 032 is a novel TOPK inhibitor as a T-LAK-cell-originated protein kinase (TOPK) inhibitor, blocking phosphorylation of the substrate histone H2AX with a...
Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and a...
Skp2 Inhibitor C1
Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibits Skp2-mediated p27 degradation by reduc...
The hydrochloride salt form of Droxicainide, a piperidine derivative, has been found to be an potential antiarrhythmic agent.
Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countr...
Nanterinone mesylate is the methyl sulfonate form of Nanterinone, which is a novel positive inotropic and balanced-type vasodilating drug partially based on pho...
BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor ...
Pseudobufarenogin is a natural compound extracted from toad species with unknown details.
Speract, a peptide associated with eggs of sea urchin, Lytechinus pictus, regulates sperm motility, also stimulates sperm mitochondrial metabolism.
Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denatur...
DL-α-Lipoic acid is an non-specific free radical scavenger and has anti-oxidant properties. It could be used as a fat-metabolism stimulator.
(Arg)9, also known as Nona-L-arginine or Peptide R9, is a cell-permeable peptide used for drug delivery with neuroprotective activity (IC50= 0.78 μM in the glut...