Edrophonium chloride - CAS 116-38-1
Catalog number:
116-38-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H16NOCl
Molecular Weight:
201.69
COA:
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Targets:
AChE
Description:
Edrophonium chloride is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts o
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Purity:
≥99%
Appearance:
Pinkish powder
Synonyms:
ETHYL[M-HYDROXYPHENYL]-DIMETHYLAMMONIUM CHLORIDE;EDROPHONIUM CHLORIDE;antirex;dimethylethyl(m-hydroxyphenyl)-ammoniuchloride;ethyl(m-hydroxyphenyl)dimethyl-ammoniuchloride;n-ethyl-3-hydroxy-n,n-dimethyl-benzenaminiuchloride;tensilon;ethyl(3-hydroxyphenyl
Solubility:
DMSO: 31 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of diseases.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
BXKDSDJJOVIHMX-UHFFFAOYSA-N
InChI:
InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
Canonical SMILES:
CC[N+](C)(C)C1=CC(=CC=C1)O.[Cl-]
1.Comparative study between sugammadex and neostigmine in neurosurgical anesthesia in pediatric patients.
Ghoneim AA1, El Beltagy MA2. Saudi J Anaesth. 2015 Jul-Sep;9(3):247-52. doi: 10.4103/1658-354X.154696.
BACKGROUND: Postoperative recurarization remains a risk following the use of the conventional neuromuscular blocking agents. In addition, none of the commonly used reversal agents, such as neostigmine or edrophonium are capable of reliably reversing profound blockade. The present comparative and randomized study investigated the use of sugammadex for reversing profound neuromuscular blockade (NMB) in pediatric neurosurgical patients undergone posterior fossa tumor excision.
2.Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry.
Draczkowski P1, Tomaszuk A1, Halczuk P1, Strzemski M1, Matosiuk D1, Jozwiak K1. Biochim Biophys Acta. 2016 May;1860(5):967-74. doi: 10.1016/j.bbagen.2015.11.006. Epub 2015 Nov 14.
BACKGROUND: Acetylcholinesterase (AChE), an enzyme rapidly terminating nerve signals at synapses of cholinergic neurons is an important drug target in treatment of Alzheimer's disease and related memory loss conditions. Here we present comprehensive use of isothermal titration calorimetry (ITC) for investigation of AChE kinetics and AChE-inhibitor interactions.
3.Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion.
Haerter F1, Eikermann M1,2. Expert Opin Pharmacother. 2016 Apr;17(6):819-33. doi: 10.1517/14656566.2016.1145667. Epub 2016 Mar 14.
INTRODUCTION: Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB).
4.Megaesophagus associated with Myasthenia Gravis: a rare condition in humans.
Desuter G, Van Parijs V, Gardiner Q. B-ENT. 2015;11(1):63-6.
We present the case of a 79 year-old patient with megaesophagus and aphagia, who required percutaneous endoscopic gastrostomy (PEG) feeding. Megaesophagus was considered the sole cause of aphagia by the referring secondary hospital. Solid state sensor videofluoromanometry (VFM) showed a substantial decrease in manometric values within the hypopharynx along with good relaxation of the upper-esophageal sphincter (UES). This led to electromyography (EMG), which showed features compatible with the diagnosis of Myasthenia Gravis (MG). The diagnosis of MG was confirmed by an intravenous injection of edrophonium chloride, performed under VFM monitoring. The co-existence of MG and megaesophagus rarely occurs in humans; although, most small animals, such as dogs, cats, and rodents, present with megaesophagus as an initial symptom of MG.
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CAS 116-38-1 Edrophonium chloride

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