Edrophonium chloride - CAS 116-38-1
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Edrophonium chloride is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts o
Publictions citing BOC Sciences Products
  • >> More
Pinkish powder
ETHYL[M-HYDROXYPHENYL]-DIMETHYLAMMONIUM CHLORIDE;EDROPHONIUM CHLORIDE;antirex;dimethylethyl(m-hydroxyphenyl)-ammoniuchloride;ethyl(m-hydroxyphenyl)dimethyl-ammoniuchloride;n-ethyl-3-hydroxy-n,n-dimethyl-benzenaminiuchloride;tensilon;ethyl(3-hydroxyphenyl
DMSO: 31 mg/mL
-20ºC Freeze
Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of diseases.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Comparative study between sugammadex and neostigmine in neurosurgical anesthesia in pediatric patients.
Ghoneim AA1, El Beltagy MA2. Saudi J Anaesth. 2015 Jul-Sep;9(3):247-52. doi: 10.4103/1658-354X.154696.
BACKGROUND: Postoperative recurarization remains a risk following the use of the conventional neuromuscular blocking agents. In addition, none of the commonly used reversal agents, such as neostigmine or edrophonium are capable of reliably reversing profound blockade. The present comparative and randomized study investigated the use of sugammadex for reversing profound neuromuscular blockade (NMB) in pediatric neurosurgical patients undergone posterior fossa tumor excision.
2.Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry.
Draczkowski P1, Tomaszuk A1, Halczuk P1, Strzemski M1, Matosiuk D1, Jozwiak K1. Biochim Biophys Acta. 2016 May;1860(5):967-74. doi: 10.1016/j.bbagen.2015.11.006. Epub 2015 Nov 14.
BACKGROUND: Acetylcholinesterase (AChE), an enzyme rapidly terminating nerve signals at synapses of cholinergic neurons is an important drug target in treatment of Alzheimer's disease and related memory loss conditions. Here we present comprehensive use of isothermal titration calorimetry (ITC) for investigation of AChE kinetics and AChE-inhibitor interactions.
3.Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion.
Haerter F1, Eikermann M1,2. Expert Opin Pharmacother. 2016 Apr;17(6):819-33. doi: 10.1517/14656566.2016.1145667. Epub 2016 Mar 14.
INTRODUCTION: Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB).
4.Megaesophagus associated with Myasthenia Gravis: a rare condition in humans.
Desuter G, Van Parijs V, Gardiner Q. B-ENT. 2015;11(1):63-6.
We present the case of a 79 year-old patient with megaesophagus and aphagia, who required percutaneous endoscopic gastrostomy (PEG) feeding. Megaesophagus was considered the sole cause of aphagia by the referring secondary hospital. Solid state sensor videofluoromanometry (VFM) showed a substantial decrease in manometric values within the hypopharynx along with good relaxation of the upper-esophageal sphincter (UES). This led to electromyography (EMG), which showed features compatible with the diagnosis of Myasthenia Gravis (MG). The diagnosis of MG was confirmed by an intravenous injection of edrophonium chloride, performed under VFM monitoring. The co-existence of MG and megaesophagus rarely occurs in humans; although, most small animals, such as dogs, cats, and rodents, present with megaesophagus as an initial symptom of MG.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related AChE Products

CAS 102518-79-6 (-)-Huperzine A (HupA)

(-)-Huperzine A (HupA)
(CAS: 102518-79-6)

(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G...

CI 1002
(CAS: 149028-28-4)

CI 1002, an azepinoquinazoline derivative, has been found to be an acetylcholinesterase inhibitor that could probably be effective against cognitive dysfunction...

CAS 357-70-0 Galanthamine

(CAS: 357-70-0)

Galanthamine, also called Razadyne, found in GALANTHUS and other AMARYLLIDACEAE, a cholinesterase inhibitor prescribed to treat symptoms of mild to moderate Alz...

CAS 125-51-9 Pipenzolate bromide

Pipenzolate bromide
(CAS: 125-51-9)

Pipenzolate bromide, a muscarinic receptor antagonist, was once considered as a spasmolytic.

CAS 1225-55-4 Protriptyline hydrochloride

Protriptyline hydrochloride
(CAS: 1225-55-4)

The hydrochloride salt of Protriptyline which is a norepinephrine uptake blocker that could be effective as an antidepressant.

CAS 51-60-5 Neostigmine Methylsulfate

Neostigmine Methylsulfate
(CAS: 51-60-5)

Neostigmine methyl sulfate is a cholinesterase inhibitor used in the treatment of myasthenia gravis, can not cross the blood-brain barrier.

CAS 209394-46-7 Ladostigil tartrate

Ladostigil tartrate
(CAS: 209394-46-7)

Ladostigil, also called as TV-3,326, is a novel neuroprotective agent developed to treat neurodegenerative disorders sunch as Alzheimer’s disease. Ladostigil is...

CAS 149062-75-9 CI-1002 hydrochloride

CI-1002 hydrochloride
(CAS: 149062-75-9)

The hydrochloride salt form of CI 1002, an azepinoquinazoline derivative, has been found to be an acetylcholinesterase inhibitor that could probably be effectiv...

Neostigmine Iodide
(CAS: 1212-37-9)

This active molecular is a reversible acetylcholinesterase inhibitor as a parasympathomimetic compound under the development of Flamel Technologies. Neostigmine...

CAS 120014-06-4 Donepezil

(CAS: 120014-06-4)

Donepezil, also called Aricept, a centrally acting reversible acetyl cholinesterase inhibitor that the FDA has also approved for the treatment of moderate to se...

(CAS: 553681-56-4)

AP2238 is a inhibitor of both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

Icopezil maleate
(CAS: 145815-98-1)

The maleate salt form of Icopezil, a benzoxazol derivative, has been found to be an acetylcholinesterase inhibitor and was once studied for the treatment of Alz...

CAS 1953-04-4 Galanthamine HBr

Galanthamine HBr
(CAS: 1953-04-4)

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.

CAS 548-66-3 Drofenine hydrochloride

Drofenine hydrochloride
(CAS: 548-66-3)

Drofenine hydrochloride is a widely used anticholinergic acts on smooth muscle to stop muscle spasms.

CAS 13473-38-6 Pipenzolate

(CAS: 13473-38-6)

Pipenzolate, a muscarinic receptor antagonist, commonly existed as bromide salt form and could be used as a spasmolytic and could probably effective in aid ther...

CAS 122892-31-3 Itopride hydrochloride

Itopride hydrochloride
(CAS: 122892-31-3)

Reversible AChE inhibitor. D2 receptor antagonist. Raises motilin and somatostatin levels. Lowers CCK levels. Shows gastroprokinetic effects in vivo. Orally act...

CAS 123441-03-2 Rivastigmine

(CAS: 123441-03-2)

Rivastigmine, a carbamate derivative, is a reversible cholinesterase inhibitor that is selective for the central nervous system to treat Alzheimer's Disease.

CAS 129101-54-8 Rivastigmine Tartrate

Rivastigmine Tartrate
(CAS: 129101-54-8)

Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to mod...

CAS 1912399-75-7 BT-11

(CAS: 1912399-75-7)

BT-11, the extract of dried root of Polygala tenuifolia Willdenow, is an orally available LANCL2 binding compound for treating inflammatory bowel disease. In ad...

CAS 101-26-8 Pyridostigmine bromide

Pyridostigmine bromide
(CAS: 101-26-8)

Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.

Chemical Structure

CAS 116-38-1 Edrophonium chloride

Quick Inquiry

Verification code

Featured Items