Edrophonium - CAS 312-48-1
Catalog number: 312-48-1
Category: Inhibitor
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Molecular Formula:
C10H16NO+
Molecular Weight:
166.24
COA:
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Targets:
AChE
Description:
Edrophonium is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of disease
Purity:
> 95%
Appearance:
Powder
Synonyms:
N-Ethyl-3-hydroxy-N,N-dimethyl-benzenaminium Chloride
Storage:
-20ºC Freeze
MSDS:
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Application:
Edrophonium is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of disease
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
VWLHWLSRQJQWRG-UHFFFAOYSA-O
InChI:
InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Canonical SMILES:
CC[N+](C)(C)C1=CC(=CC=C1)O
1.The effect of cholinesterase inhibitors on the antimuscarinic effect of hemicholinium-3 (HC-3) in the rat.
Hecker SE;Mitchelson F J Pharm Pharmacol. 1976 May;28(5):441-6.
The effect of hemicholinium-3 (HC-3) on responses of the rat isolated bladder and ileum to acetylcholine and carbachol was investigated in the absence and presence of a number of anticholinesterases. Responses of the bladder to acetylcholine were potentiated by DFP, edrophonium, BW284C51 and physostigmine but were unaffected by the specific butyrylcholinesterase inhibitor iso-OMPA. Responses to carbachol were not potentiated by the anticholinesterases. HC-3 (1.7 X 10(-4) M) inhibited responses to carbachol without affecting those to acetylcholine. In the presence of physostigmine or DFP responses to acetylcholine were inhibited by HC-3 but no such inhibition was observed in the presence of BW284C51, edrophonium or iso-OMPA or a combination of the latter two anticholinesterases. Responses to carbachol were also inhibited to a greater extent in the presence of DFP. In the ileum, responses to acetylcholine were increased in the presence of DFP, edrophonium and physostigmine but were unaffected by iso-Ompa. responses to carbachol were not increased by any of the anticholinesterases. HC-3 (2.8 X 10(-4) M) inhibited responses to both acetylcholine and carbachol in the ileum and the degree of inhibition was not significantly altered by the presence of any of the anticholinesterases used.
2.Reversal of asynchrony between circular and longitudinal muscle contraction in nutcracker esophagus by atropine.
Korsapati H;Bhargava V;Mittal RK Gastroenterology. 2008 Sep;135(3):796-802. doi: 10.1053/j.gastro.2008.05.082. Epub 2008 Jun 12.
BACKGROUND & AIMS: ;Patients with high-amplitude esophageal contractions (nutcracker esophagus [NCE]) show asynchrony of circular muscle (CM) and longitudinal muscle (LM) contraction during peristalsis. The goal of our study was to determine if this asynchrony is related to an increase in the cholinergic receptor activity.;METHODS: ;High-frequency intraluminal ultrasound images and pressures of the esophagus were recorded simultaneously in 10 normal subjects and 10 patients with NCE. Recordings were obtained at 2 cm above the lower esophageal sphincter under 2 study conditions in normal subjects (before and after 80 microgm/kg of edrophonium), and under 3 study conditions in the NCE patients (control, 5 microgm and 10 microgm/kg of atropine).;RESULTS: ;In normal subjects, edrophonium induced an increase in the CM and LM contraction amplitude, an increase in the contraction duration, and asynchrony of LM and CM contraction during peristalsis. On the other hand, increased contraction amplitude, duration, and asynchrony of LM and CM contraction observed at the baseline in the NCE patients were reversed by atropine in a dose-dependent fashion.;CONCLUSIONS: ;These data prove that the esophageal motor abnormalities in patients with nutcracker esophagus, including asynchrony of CM and LM contraction, are related to a hypercholinergic state.
3.Antagonism of pancuronium and tubocurarine blocks by edrophonium or neostigmine: a comparative study.
Mirakhur RK Eur J Anaesthesiol. 1987 Nov;4(6):411-9.
Edrophonium 0.5 and neostigmine 0.05 mg kg-1 were compared as antagonists of pancuronium and tubocurarine-induced neuromuscular blocks, at varying degrees of recovery, in groups of 20 patients each. Adequate antagonism was defined as attaining a sustained train-of-four (TOF) ratio of 0.7 or more. Administration of edrophonium was associated with a more rapid onset of action (17 s with both relaxants with edrophonium, and 31 s and 29 s with neostigmine with pancuronium and tubocurarine, respectively), and a shorter time to attain a TOF ratio of 0.7 (74 s and 48 s with edrophonium and 230 s and 293 s with neostigmine for pancuronium and tubocurarine blocks, respectively). However, whereas neostigmine administration provided adequate antagonism in all 20 patients given pancuronium and in 19 out of 20 patients given tubocurarine, edrophonium failed to achieve adequate antagonism in six patients after pancuronium and eight patients after tubocurarine. The majority of these patients had shown three or less responses to a TOF stimulation prior to antagonism. Two separate groups of 10 patients each with relatively deeper pancuronium or tubocurarine blocks (three or less responses to TOF stimulation) were given edrophonium in a dose of 1.
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CAS 312-48-1 Edrophonium

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