Edaravone - CAS 89-25-8
Catalog number: 89-25-8
Category: Inhibitor
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Edaravone is a novel potent free radical scavenger that reduces reactive oxygen species, inhibites apoptosis, and blocks nonenzymatic peroxidation and lipoxygenase activity.
Edaravone; MCI-186; MCI 186; MCI186; Radicut; Arone
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1.Edaravone suppresses degradation of type II collagen.
Huang C1, Liao G2, Han J2, Zhang G2, Zou B2. Biochem Biophys Res Commun. 2016 Mar 30. pii: S0006-291X(16)30448-X. doi: 10.1016/j.bbrc.2016.03.136. [Epub ahead of print]
Osteoarthritis (OA) is a degenerative joint disease affecting millions of people. The degradation and loss of type II collagen induced by proinflammatory cytokines secreted by chondrocytes, such as factor-α (TNF-α) is an important pathological mechanism to the progression of OA. Edaravone is a potent free radical scavenger, which has been clinically used to treat the neuronal damage following acute ischemic stroke. However, whether Edaravone has a protective effect in articular cartilage hasn't been reported before. In this study, we investigated the chondrocyte protective effects of Edaravone on TNF-α induced degradation of type Ⅱ collagen. And our results indicated that TNF-α treatment resulted in degradation of type Ⅱ collagen, which can be ameliorated by treatment with Edaravone in a dose dependent manner. Notably, it was found that the inhibitory effects of Edaravone on TNF-α-induced reduction of type Ⅱ collagen were mediated by MMP-3 and MMP-13.
2.Protective Effects of Edaravone in Adult Rats with Surgery and Lipopolysaccharide Administration-Induced Cognitive Function Impairment.
Wang P1, Cao J1, Liu N1,2, Ma L1,3, Zhou X1, Zhang H1, Wang Y4. PLoS One. 2016 Apr 26;11(4):e0153708. doi: 10.1371/journal.pone.0153708. eCollection 2016.
Postoperative cognitive dysfunction (POCD) is a clinical syndrome characterized by cognitive declines in patients after surgery. Previous studies have suggested that surgery contributed to such impairment. It has been proven that neuroinflammation may exacerbate surgery-induced cognitive impairment in aged rats. The free radical scavenger edaravone has high blood brain barrier permeability, and was demonstrated to effectively remove free radicals from the brain and alleviate the development of POCD in patients undergoing carotid endarterectomy, suggesting its potential role in preventing POCD. For this reason, this study was designed to determine whether edaravone is protective against POCD through its inhibitory effects on inflammatory cytokines and oxidative stress. First, Sprague Dawley adult male rats were administered 3 mg/kg edaravone intraperitoneally after undergoing a unilateral nephrectomy combined with lipopolysaccharide injection.
3.Could edaravone prevent gentamicin ototoxicity? An experimental study.
Turan M1, Ciğer E2, Arslanoğlu S2, Börekci H3, Önal K2. Hum Exp Toxicol. 2016 Mar 27. pii: 0960327116639360. [Epub ahead of print]
OBJECTIVES: Clinical application of gentamicin may cause nephrotoxicity and ototoxicity. Our study is the first study to investigate the protective effects of edaravone against the gentamicin-induced ototoxicity. We investigated the protective effect of intraperitoneal (i.p.) edaravone application against gentamicin-induced ototoxicity in guinea pigs.
4.Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model.
Zhang GW1, Gu TX2, Sun XJ3, Wang C4, Qi X5, Wang XB6, Li-Ling J7. J Thorac Cardiovasc Surg. 2016 Mar 12. pii: S0022-5223(16)00430-X. doi: 10.1016/j.jtcvs.2016.02.071. [Epub ahead of print]
OBJECTIVE: To explore the effect of edaravone on bone marrow mesenchymal stem cells (BMSCs) transplanted to treat acute myocardial infarction (AMI) and the underlying mechanism.
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CAS 89-25-8 Edaravone

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