Echinacoside - CAS 82854-37-3
Catalog number: 82854-37-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C35H46O20
Molecular Weight:
786.73
COA:
Inquire
Targets:
Others
Description:
Echinacoside, a natural polyphenolic compound, has various kinds of pharmacological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative ones.
Purity:
>98%
MSDS:
Inquire
InChIKey:
FSBUXLDOLNLABB-ISAKITKMSA-N
InChI:
InChI=1S/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1
Canonical SMILES:
CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O
1.Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MS(n) combined with bioassays.
Shen L1, Chen H1, Zhu Q1, Wang Y1, Wang S2, Qian J2, Wang Y3, Qu H1. J Pharm Biomed Anal. 2016 Jan 5;117:363-71. doi: 10.1016/j.jpba.2015.09.024. Epub 2015 Sep 25.
Fufang Ejiao Syrup (FES) is a widely used immune-boosting Traditional Chinese Medicine (TCM) in Eastern Asian countries. This study attempts to investigate the bioactive compounds in FES. First, FES extract was separated into fractions to facilitate the investigation and 72 compounds were identified using LC-MS(n). Subsequently, Immune-enhancement effects of FES and its components were investigated on bone marrow cells and neuroprotective effects against H2O2 induced oxidative damage were evaluated in SH-SY5Y neuroblastoma cells and bEnd.3. Our results indicated that fraction 3, 5, 6 and 8 showed significant improvements on immune function, while several fractions had cytoprotective effects against H2O2-induced oxidative injury. Jionoside A1 isolated from Radix Rehmanniae Praeparata displayed dose dependent immune-enhancement activity. 20(R)-ginsenoside Rg3 could protect bEnd.3 against oxidative damage. Furthermore, echinacoside, jionoside A1, vitexin-2-O-rhamnoside, acteoside and isoacteoside possessed moderate protective activities on H2O2-treated SH-SY5Y cells.
2.Secoiridoids and other chemotaxonomically relevant compounds in Pedicularis: phytochemical analysis and comparison of Pedicularis rostratocapitata Crantz and Pedicularis verticillata L. from Dolomites.
Venditti A1,2, Frezza C2, Sciubba F1, Foddai S2, Serafini M2, Nicoletti M2, Bianco A1. Nat Prod Res. 2016 Feb 1:1-8. [Epub ahead of print]
We compared the respective metabolite patterns of two Pedicularis species from Dolomites. Seven phenylethanoid glycosides, i.e., verbascoside (1), echinacoside (2), angoroside A (3), cistantubuloside B1 (4), wiedemannioside C (5), campneoside II (11) and cistantubuloside C1 (12), together with several iridoid glucosides as aucubin (6), euphroside (7), monomelittoside (8), mussaenosidic acid (9) and 8-epiloganic acid (13) were identified. Pedicularis verticillata showed also the presence of greatly unexpected secoiridoids, ligustroside (14) and excelside B (15), very rare compounds in Lamiales. Both PhGs and iridoids are considered of taxonomical relevance in the Asteridae and their occurrence in Pedicularis was discussed. In particular, the exclusive presence of several compounds such as 8-epiloganic acid (13), campneoside II (11), cistantubuloside C1 (12), ligustroside (14) and excelside B (15) in Pedicularis rostratocapitata, and angoroside A (3), cistantubuloside B1 (4) and wiedemannioside C (5) in P.
3.Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway.
Wang W1, Luo J1, Liang Y1, Li X1. Mol Med Rep. 2016 Mar;13(3):2613-8. doi: 10.3892/mmr.2016.4867. Epub 2016 Feb 4.
The clinical application of natural products derived from traditional Chinese medicine has gained attention in cancer chemotherapeutics. Echinacoside (ECH), one of the phenylethanoids, isolated from the stems of Cistanches salsa (a Chinese herbal medicine) has tissue‑protective and anti‑apoptotic effects on the central nervous system. However, it remains largely elusive whether ECH possesses tumor suppressive activity. In the present study, it was demonstrated that ECH can markedly inhibit the proliferation of pancreatic adenocarcinoma cells by inducing the production of reactive oxygen species and the perturbation of mitochondrial membrane potential and thus triggering apoptosis. Furthermore, it was elucidated that ECH represses tumor cell growth through modulating MAPK activity. In conclusion, this study reveals an novel function of ECH in preventing cancer development, and implies that the usage of ECH could be a potential chemotherapeutic strategy for cancer.
4.Screening and identification of three typical phenylethanoid glycosides metabolites from Cistanches Herba by human intestinal bacteria using UPLC/Q-TOF-MS.
Li Y1, Zhou G1, Peng Y1, Tu P2, Li X3. J Pharm Biomed Anal. 2016 Jan 25;118:167-76. doi: 10.1016/j.jpba.2015.10.038. Epub 2015 Oct 31.
Acteoside, isoacteoside, and 2'-acetylacteoside are three representative phenylethanoid glycosides (PhGs), which are widely distributed in many plants and also known as the active components of Cistanches Herba. However, the extremely low oral bioavailability of acteoside in rats implies that these structural similar components may go through multiple sequential routes of hydrolysis in gastrointestinal tract before they are absorbed into blood. Therefore, the metabolites of these three components and other PhGs from gastrointestinal tract such as echinacoside, are supposed to be the bioactive elements. In this study, we established an approach combining ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) with MS(E) technology and MetaboLynx™ software for the rapid metabolic profiling of acteoside, isoacteoside, and 2'-acetylacteoside by human intestinal bacteria. As a result, 11 metabolites of acteoside, 7 metabolites of isoacteoside, and 11 metabolites of 2'-acetylacteoside were identified respectively.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 832729-13-2 LF 11

LF 11
(CAS: 832729-13-2)

LF 11 is a peptide based on the lipopolysaccharide-binding region of human lactoferricin. It shows antimicrobial activity against gram-negative and gram-positiv...

CAS 52286-58-5 Ginsenoside Rf

Ginsenoside Rf
(CAS: 52286-58-5)

Ginsenoside Rf, extracted from the traditional Chinese herb ginseng, an anti-arthritic agent, attenuating collagen-induced arthritis in mice.

CAS 1391737-01-1 VU 0463271

VU 0463271
(CAS: 1391737-01-1)

VU 0463271 is a potent and selective inhibitor of KCC2, which is a neuronal K-Cl cotransporter (IC50 = 61 nM). VU 0463271 exhibits >100-fold selectivity versus ...

CAS 88519-57-7 W-13 hydrochloride

W-13 hydrochloride
(CAS: 88519-57-7)

W-13 hydrochloride is a calmodulin antagonist that inhibits calmodulin activated PDE activity with an IC50 of 68 μM.

FITC-ASTD-FMK

FITC-ASTD-FMK is a fluorescein isothiocyanate (FITC)-conjugated inhibitor of endothelial monocyte-activated polypeptide II (EMAP II), which can be used as a mar...

Cgp 13143
(CAS: 75919-69-6)

Cgp 13143 is a bio-active chemical,but no detailed information has been published yet.

CAS 67-48-1 Choline Chloride

Choline Chloride
(CAS: 67-48-1)

Choline chloride is a quaternary ammonium salt used as an additive for animal feed, especially for chickens where it accelerates growth.

CAS 83461-56-7 Mifamurtide

Mifamurtide
(CAS: 83461-56-7)

Mifamurtide is a liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities. It is a deri...

Chemical Structure

CAS 82854-37-3 Echinacoside

Quick Inquiry

Verification code

Featured Items