eCF506 - CAS 1914078-41-3
Catalog number: 1914078-41-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H38N8O3
Molecular Weight:
510.643
COA:
Inquire
Targets:
Src
Description:
eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentration (IC50 < 0.5 nM). It is said that eCF506 is the first drug candidate of a second generation of Src inhibitors that will not only help to understand the complexity of some cancers but also the development of safer combination therapies.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate; eCF506; Derivative 11a; GTPL9186; derivative 11a [PMID: 27115835]; tert-butyl N-[4-(4-amino-1-{2-[4-(dimethylamino)piperidin-1-yl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate
MSDS:
Inquire
InChIKey:
GMPQGWXPDRNCBL-UHFFFAOYSA-N
InChI:
1S/C26H38N8O3/c1-26(2,3)37-25(35)30-19-8-7-17(15-20(19)36-6)22-21-23(27)28-16-29-24(21)34(31-22)14-13-33-11-9-18(10-12-33)32(4)5/h7-8,15-16,18H,9-14H2,1-6H3,(H,30,35)(H2,27,28,29)
Canonical SMILES:
CC(C)(C)OC(=O)NC1=C(C=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)CCN4CCC(CC4)N(C)C)OC
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Src Products


CAS 847950-09-8 Lck Inhibitor

Lck Inhibitor
(CAS: 847950-09-8)

Lck Inhibitor is a small-molecule inhibitor. It takes participate in the T-cell receptor (TCR) signal transduction and affects the expression of genes associate...

HG-9-91-01
(CAS: 1456858-58-4)

HG-9-91-01,a small molecule inhibitor that targets specificly salt-inducible kinase (SIKs) IC50: SIK1=0.92 nM; SIK2=6.6 nM; SIK3=9.6 nM

CAS 518058-84-9 KX1-004

KX1-004
(CAS: 518058-84-9)

KX1-004 is an Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. KX1-004 has been used to protect the...

CAS 529-53-3 Scutellartln

Scutellartln
(CAS: 529-53-3)

Scutellarein is a flavonoid isolated from Scutellaria lateriflora could improve neuronal injury.

CAS 380843-75-4 Bosutinib

Bosutinib
(CAS: 380843-75-4)

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

AP-22161
(CAS: 268741-42-0)

AP-2216, designed to bind selectively to the Src SH2 domain by targeting a cysteine residue, has the potential to be further developed for treating osteoporosis...

CAS 364042-47-7 A 419259

A 419259
(CAS: 364042-47-7)

A-419259 is a potent inhibitor of Src family kinases. IC50 values for src, lck, blk, csk, fyn and lyn range between 15 and 50 nM.

CAS 837422-57-8 WH-4-023

WH-4-023
(CAS: 837422-57-8)

WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively. The lymphocyte-specific kinase (Lck) is a ...

CAS 867331-64-4 TG 100572 Hydrochloride

TG 100572 Hydrochloride
(CAS: 867331-64-4)

TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases for VEGFR1/VEGFR2/FGFR1/Src/Fy...

CAS 944795-06-6 Lck inhibitor 2

Lck inhibitor 2
(CAS: 944795-06-6)

Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. It inhibited 48 kinases with control less than 1...

CAS 330161-87-0 SU6656

SU6656
(CAS: 330161-87-0)

SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc (a subsidiary of Pharmacia) in 2000. SU6656 was initially identified as...

eCF506
(CAS: 1914078-41-3)

eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentr...

CAS 1435934-25-0 A 419259 trihydrochloride

A 419259 trihydrochloride
(CAS: 1435934-25-0)

Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including...

CAS 172889-26-8 PP1

PP1
(CAS: 172889-26-8)

CHMFL-ABL-053
(CAS: 1808287-83-3)

CHMFL-ABL-053 is a potent and orally available inhibitor of BCR-ABL (IC50 = 70nM) without inhibitory activity against c-KIT kinase that is a common target of BC...

CAS 882663-88-9 AMG-47a

AMG-47a
(CAS: 882663-88-9)

AMG-47a is a potent inhibitor of Lck and T cell proliferation. It has anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in...

CAS 172889-27-9 PP2

PP2
(CAS: 172889-27-9)

CAS 869748-10-7 A-770041

A-770041
(CAS: 869748-10-7)

A-770041 is an selective and orally bioavailable pyrazolo[3,4-d]pyrimidine exhibiting selectivity for Lck compared with previously reported compounds. It is 300...

T338C Src-IN-1
(CAS: 1351926-90-3)

T338C Src-IN-1, a pyrazolopyrimidine detivative, has been found effective T338C inhibition and could be significant for determing the effect of kinases by Chemi...

CAS 379231-04-6 Saracatinib

Saracatinib
(CAS: 379231-04-6)

Saracatinib, also known as AZD0530, is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. Src and Abl are...

Quick Inquiry

Verification code

Featured Items