Ebrotidine - CAS 100981-43-9
Catalog number: 100981-43-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C14H17BrN6O2S3
Molecular Weight:
477.43
COA:
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Targets:
Histamine Receptor
Description:
Ebrotidine(FI 3542), a competitive H2-receptor antagonist, has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. IC50: 127.5 nM (Ki)[1]; 0.21mg/kg (ED50, histamine- stimulated acid secretion). It also
Purity:
95%
Appearance:
Powder
Synonyms:
FI-3542; FI 3542; FI3542; Ebrotidine.
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist and has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
672.3ºC at 760mmHg
Density:
1.73g/cm3
InChIKey:
ZQHFZHPUZXNPMF-UHFFFAOYSA-N
InChI:
InChI=1S/C14H17BrN6O2S3/c15-10-1-3-12(4-2-10)26(22,23)19-9-18-5-6-24-7-11-8-25-14(20-11)21-13(16)17/h1-4,8-9H,5-7H2,(H,18,19)(H4,16,17,20,21)
Canonical SMILES:
C1=CC(=CC=C1S(=O)(=O)NC=NCCSCC2=CSC(=N2)N=C(N)N)Br
1.Multivariate calibration methods for quantification in strongly overlapping capillary electrophoretic peaks.
Sentellas S1, Saurina J, Hernández-Cassou S, Galceran MT, Puignou L. J Chromatogr A. 2001 Feb 16;909(2):259-69.
Capillary zone electrophoresis with diode-array detection was applied to the separation of ebrotidine and its metabolites. However, three of these, which are neutral in the conditions studied, co-migrated with the electroosmotic flow signal. Therefore, strongly overlapping peaks were observed. The main aim of this study was to show the potentiality of capillary electrophoresis in combination with chemometrics. Multivariate calibration methods were applied to quantify these analytes in synthetic mixtures. The results obtained using partial least squares (PLS) were in agreement with actual values, with an overall prediction error of 9.7%.
2.Omeprazole fails to suppress up-regulation of gastric mucosal endothelin-converting enzyme-1 by Helicobacter pylori lipopolysaccharide.
Slomiany BL1, Piotrowski J, Slomiany A. J Physiol Pharmacol. 2000 Sep;51(3):421-31.
BACKGROUND: Endothelin-1, a key mediator of inflammatory processes, is produced from its biologically inactive precursor, big ET- by the action of endothelin converting enzyme-1(ECE-1). In this study, we applied the animal model of H. pylori lipopolysaccharide-induced gastritis to assess the effect of three different types of antiulcer agents on the gastric mucosal expression of ECE-1 activity.
3.Quantitation in multianalyte overlapping peaks from capillary electrophoresis runs using artificial neural networks.
Sentellas S1, Saurina J, Hernández-Cassou S, Galceran MT, Puignou L. J Chromatogr Sci. 2003 Mar;41(3):145-50.
The potentiality of artificial neural networks for multicomponent analysis in unresolved peaks from capillary electrophoresis (CE) is evaluated. The system chosen consists of mixtures of three ebrotidine metabolites, which cannot be successfully separated by CE. Data selected for analysis consist of UV spectra taken at the maximum of the CE peak. The most dissimilar analyte, in terms of spectral differences, is accurately quantitated in any type of mixture with an overall prediction error of 5%. Because of the strong interference of the two most overlapped compounds, a preliminary procedure for spectral data filtering based on principal component analysis is performed to improve their quantitation.
4.Determination of ebrotidine metabolites in overlapping peaks from capillary zone electrophoresis using chemometric methods.
Sentellas S1, Saurina J, Hernández-Cassou S, Galceran MT, Puignou L. Electrophoresis. 2001 Jan;22(1):71-6.
This paper illustrates the possibilities of chemometric methods in the resolution and quantification of various compounds in overlapping peaks from capillary electrophoresis. Ebrotidine and most of its metabolites were efficiently separated by capillary zone electrophoresis (CZE) in a fused-silica capillary. However, the procedure was not suitable for the physical separation of the three less ionizable metabolites, which comigrated and overlapped with the electroosmotic flow signal. Multivariate curve resolution based on an alternating least squares procedure was used for their mathematical resolution. For such a purpose, data obtained in the CZE system with a diode array detector, which consisted of UV spectra registered over time, were analyzed. The ebrotidine metabolites were successfully resolved and quantified in synthetic mixtures and urine samples.
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CAS 100981-43-9 Ebrotidine

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