Ebrotidine - CAS 100981-43-9
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Histamine Receptor
Ebrotidine(FI 3542), a competitive H2-receptor antagonist, has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. IC50: 127.5 nM (Ki)[1]; 0.21mg/kg (ED50, histamine- stimulated acid secretion). It also
Publictions citing BOC Sciences Products
  • >> More
10 mM in DMSO
-20ºC Freeze
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist and has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
672.3ºC at 760mmHg
Canonical SMILES:
1.Multivariate calibration methods for quantification in strongly overlapping capillary electrophoretic peaks.
Sentellas S1, Saurina J, Hernández-Cassou S, Galceran MT, Puignou L. J Chromatogr A. 2001 Feb 16;909(2):259-69.
Capillary zone electrophoresis with diode-array detection was applied to the separation of ebrotidine and its metabolites. However, three of these, which are neutral in the conditions studied, co-migrated with the electroosmotic flow signal. Therefore, strongly overlapping peaks were observed. The main aim of this study was to show the potentiality of capillary electrophoresis in combination with chemometrics. Multivariate calibration methods were applied to quantify these analytes in synthetic mixtures. The results obtained using partial least squares (PLS) were in agreement with actual values, with an overall prediction error of 9.7%.
2.Omeprazole fails to suppress up-regulation of gastric mucosal endothelin-converting enzyme-1 by Helicobacter pylori lipopolysaccharide.
Slomiany BL1, Piotrowski J, Slomiany A. J Physiol Pharmacol. 2000 Sep;51(3):421-31.
BACKGROUND: Endothelin-1, a key mediator of inflammatory processes, is produced from its biologically inactive precursor, big ET- by the action of endothelin converting enzyme-1(ECE-1). In this study, we applied the animal model of H. pylori lipopolysaccharide-induced gastritis to assess the effect of three different types of antiulcer agents on the gastric mucosal expression of ECE-1 activity.
3.Quantitation in multianalyte overlapping peaks from capillary electrophoresis runs using artificial neural networks.
Sentellas S1, Saurina J, Hernández-Cassou S, Galceran MT, Puignou L. J Chromatogr Sci. 2003 Mar;41(3):145-50.
The potentiality of artificial neural networks for multicomponent analysis in unresolved peaks from capillary electrophoresis (CE) is evaluated. The system chosen consists of mixtures of three ebrotidine metabolites, which cannot be successfully separated by CE. Data selected for analysis consist of UV spectra taken at the maximum of the CE peak. The most dissimilar analyte, in terms of spectral differences, is accurately quantitated in any type of mixture with an overall prediction error of 5%. Because of the strong interference of the two most overlapped compounds, a preliminary procedure for spectral data filtering based on principal component analysis is performed to improve their quantitation.
4.Determination of ebrotidine metabolites in overlapping peaks from capillary zone electrophoresis using chemometric methods.
Sentellas S1, Saurina J, Hernández-Cassou S, Galceran MT, Puignou L. Electrophoresis. 2001 Jan;22(1):71-6.
This paper illustrates the possibilities of chemometric methods in the resolution and quantification of various compounds in overlapping peaks from capillary electrophoresis. Ebrotidine and most of its metabolites were efficiently separated by capillary zone electrophoresis (CZE) in a fused-silica capillary. However, the procedure was not suitable for the physical separation of the three less ionizable metabolites, which comigrated and overlapped with the electroosmotic flow signal. Multivariate curve resolution based on an alternating least squares procedure was used for their mathematical resolution. For such a purpose, data obtained in the CZE system with a diode array detector, which consisted of UV spectra registered over time, were analyzed. The ebrotidine metabolites were successfully resolved and quantified in synthetic mixtures and urine samples.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products

Levoprotiline hydrochloride
(CAS: 76496-69-0)

Levoprotiline is a Histamine H1 receptor antagonist originated by Novartis. It is an antidepressant. But clinical trials for Major depressive disorder were disc...

Famotine hydrochloride
(CAS: 10500-82-0)

Famotine hydrochloride is a histamine H2 receptor antagonist. lt has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other ...

CAS 544707-19-9 JNJ10181457 dihydrochloride

JNJ10181457 dihydrochloride
(CAS: 544707-19-9)

JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 ...

CAS 442-52-4 Clemizole

(CAS: 442-52-4)

Clemizole is an H1 antagonist acts as a TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respecti...

CAS 184025-18-1 Ciproxifan

(CAS: 184025-18-1)

Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

CAS 459168-41-3 JNJ-7777120

(CAS: 459168-41-3)

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other h...

CAS 118288-08-7 Lafutidine

(CAS: 118288-08-7)

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

CAS 73903-17-0 JNJ-10191584

(CAS: 73903-17-0)

JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and ana...

CAS 58581-89-8 Azelastine

(CAS: 58581-89-8)

Azelastine, a phthalazine derivative, is a potent, second-generation, selective, histamine antagonist used as a first line therapy of mild intermittent.

CAS 1104-22-9 Meclizine 2HCl

Meclizine 2HCl
(CAS: 1104-22-9)

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation...

CAS 113-69-9 Benzquinamide Hydrochloride

Benzquinamide Hydrochloride
(CAS: 113-69-9)

Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure an...

CAS 562-10-7 Doxylamine Succinate

Doxylamine Succinate
(CAS: 562-10-7)

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.

CAS 2438-32-6 Dexchlorpheniramine maleate

Dexchlorpheniramine maleate
(CAS: 2438-32-6)

Dexchlorpheniramine maleate, also known as Polaramine, is an antihistamine to treat allergic conditions, urticaria and allergic conjunctivitis and pruritus.

(CAS: 1192559-94-6)

This active molecular is a imidazolylpropylguanidine type compound as a hH4R agonist (histamine H4 receptor agonist) showing negligible hH1R and hH2R activities...

CAS 87848-99-5 Acrivastine

(CAS: 87848-99-5)

Acrivastine, also known as BW825C, is an antihistamine with peripheral H1-antagonist potency equal to that of triprolidine for the treatment of allergic rhiniti...

CAS 80012-43-7 Epinastine

(CAS: 80012-43-7)

Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for ...

CAS 83881-51-0 Cetirizine

(CAS: 83881-51-0)

Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine. It is a racemic selective H1 receptor inverse agonist. It is used in cutane...

CAS 2508-72-7 Antazoline hydrochloride

Antazoline hydrochloride
(CAS: 2508-72-7)

Antazoline HCl is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.

CAS 523-87-5 Dramamine

(CAS: 523-87-5)

Dimenhydrinate is an over-the-counter antiemetic used to prevent nausea and motion sicknes composed of 8-Chlorotheophylline and Diphenhydramine.

FR-A 19
(CAS: 141099-46-9)

FR-A 19 is a Histamine H2 receptor agonist with potent anti-allergic properties. It can inhibit IgE-mediated human basophil histamine release in a nanomolar ran...

Chemical Structure

CAS 100981-43-9 Ebrotidine

Quick Inquiry

Verification code

Featured Items