|Description||(±)-E-Homocamptothecin is a potent topoisomerase I (Topo 1) inhibitor.|
|Brife Description||topoisomerase I (Topo 1) inhibitor|
|Synonyms||(+/-)-E-Homocamptothecin; BN-80245; E-Homocamptothecin, (+/-)-|
Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes top...
Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.
Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand break...
The deuterium labeled banoxantrone which was rationally designed to have anti-tumor activity following bioreduction by tissue cytochrome P450 to AQ4, an active ...
Bisantrene is an anthracenyl bishydrazone used as a particular anticancer drug. Bisantrene can lead to inhibition of DNA replicantion and DNA-protein crosslinki...
Amsacrine is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibit...
Exatecan Mesylate (DX-8951) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous sol...
UK-1, a benzoxazol derivative, has been found to a Streptomyces metabolite that could exhibit anticancer activity and topoisomerase II restraination activity.