|Description||Capsaicin, the major pungent ingredient found in hot red chili peppers of the genus Capsicum, suppresses the growth of several malignant cell lines.|
|Appearance||White to Off-White Solid|
|Synonyms||Capsaicinoids; Capsaicin; (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide;|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Quality Standard||Enterprise Standard/CP|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
|Melting Point||67-69 °C|
|Current Developer||Alopecia Areata|
Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-RO...
The hydrochloride salt form of SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC.
BCTC is a TRPA1 and TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.
PF-05105679 is a selective TRPM8 Antagonist with clinical efficacy in cold-related pain. IC50 value is 103 nM. It shows >100-fold selectivity for TRPM8 over a p...
Capsaicin, the major pungent ingredient found in hot red chili peppers of the genus Capsicum, suppresses the growth of several malignant cell lines.
Nonivamide, also called as N-Vanillylnonanamide, a synthetic analogue of Capsaicin isolated from peppers, is a VR1 (TRPV1) agonist.
Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures.
AMG-9810 is potent, non-vanilloid and selective TRPV1 receptor antagonist with IC50 value of 17 nM. It inhibits capsaicin-, proton-, heat- and endogenous ligand...
SN 2 is a novel and potent small molecule activator of TRPML3. Its EC50 value is 1.13 uM. It had a similar synergistic effect and reached up-to 10-fold enhancem...
AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 µM at human and mouse...
TRPV antagonist 1
TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist (IC50= < 250 nM).
GSK2193874 is a potent, orally active and specific antagonist of TRPV4 ion channels (IC50 values= 2 and 40 nM for rat and human receptors, respectively). GSK219...
AMG-517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
AMG8562 is a novel vanilloid receptor TRPV1 modulator.
PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively.
SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC.
Pyr6, a pyrazole derivative, is a selective inhibitor of ransient receptor potential cation 3 (TRPC3) channels that inhibited Orai1- and TRPC3-mediated Ca(2+) e...
ABT 102 is a selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with IC50 values to be 5-7 nM. No recent reports of development iden...
WS12 is a potent TRPM8 agonist. It acts as a cooling agent with EC50 value of 193 nM. It robustly activated TRPM8 in low micromolar concentrations, thus display...
Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CY...