Dydrogesterone - CAS 152-62-5
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Molecular Weight:
Progesterone Receptor
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
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1.Dydrogesterone support following assisted reproductive technique (ART) reduces the risk of pre-eclampsia.
Ali AB, Ahmad MF, Kwang NB, Shan LP, Shafie NM, Omar MH. Horm Mol Biol Clin Investig. 2016 Feb 24. pii: /j/hmbci.ahead-of-print/hmbci-2015-0063/hmbci-2015-0063.xml. doi: 10.1515/hmbci-2015-0063. [Epub ahead of print]
BACKGROUND: Pre-eclampsia (PE) contributes to poor maternal morbidity and mortality. Progesterone is hypothesised to reduce the risk of PE.
2.Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo.
Rossier NM1, Chew G2, Zhang K2, Riva F3, Fent K4. Aquat Toxicol. 2016 May;174:109-22. doi: 10.1016/j.aquatox.2016.02.005. Epub 2016 Feb 22.
Despite potential exposure of aquatic organisms to mixtures of steroid hormones, very little is known on their joint activity in fish. Drospirenone (DRS) is a new synthetic progestin used in contraceptive pills in combination with 17α-ethinylestradiol (EE2). Here we systematically analyzed effects of DRS in binary mixtures with progesterone (P4) and EE2. First, we determined the in vitro activity of single compounds in recombinant yeast assays that express the human progesterone, androgen, or estrogen receptor, followed by determination of mixture activities of DRS and P4, DRS and EE2, as well as medroxyprogesterone acetate (MPA) and dydrogesterone (DDG). Mixtures of DRS and P4, as well as of DRS and EE2 showed additive progestogenic and androgenic activities. However, DDG and MPA showed non-additive progestogenic and androgenic activities. We then analyzed the in vivo activity of single compounds and mixtures of DRS and P4, as well as DRS and EE2, by assessing transcriptional changes of up to 14 selected target genes in zebrafish embryos at 48h post fertilization (hpf), and in eleuthero-embryos at 96hpf and 144hpf.
3.[Analysis of the follow-up results concerning pregnancy, delivery and infants after assisted reproductive technique with GnRH-a for luteal support].
Zhou WQ1, Pan YP, Zhuang YY, Xia F, Mao CP. Zhonghua Fu Chan Ke Za Zhi. 2016 Jan 25;51(1):31-5. doi: 10.3760/cma.j.issn.0529-567X.2016.01.008.
OBJECTIVE: To investigate the results of follow-up visits of pregnancy course, delivery and infants of women who got clinically pregnant by assisted reproductive technique after gonadotropin-releasing hormone agonist (GnRH-a) added for luteal support, and to analyse the influence of adding GnRH-a in luteal support on the safety of mother and infant.
4.Reduction in the level of antibodies against heat shock proteins 60 during different hormonal protocols in postmenopausal women.
Rajtar-Ciosek A1, Kacalska-Janssen O1, Zmaczyński A1, Wyroba J1, Tomczyk R1, Wiatr J1, Gałuszka-Bednarczyk A1, Bereza T1, Milewicz T1, Krzysiek J1. Prz Menopauzalny. 2015 Dec;14(4):218-22. doi: 10.5114/pm.2015.56402. Epub 2015 Dec 16.
INTRODUCTION: In current literature, the immune-inflammatory theory of atherosclerosis is widely discussed. The role of how heat shock proteins 60 (HSP60) lead to the development of the atheromatous plaque is especially underlined. The aim of the study is to estimate the influence of three hormonal protocols on behavior of antibodies against HSP60. It determines the state of endothelium in postmenopausal women.
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