|Description||DY131 is a novel selective agonist of ERRβ and ERRγ, which displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. It could potentiate the ERRγ-induced growth inhibition in DU145- ERRγ and LNCaP- ERRγ prostate cancer cells in a dose-dependent manner. It inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. It had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). It appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. It has been demonstrated an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.|
|Solubility||DMSO: ≥14 mg/mL|
|Application||DY131 has been demonstrated an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Melting Point||234-236 °C|
|Density||1.11±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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