DY131 - CAS 95167-41-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H21N3O2
Molecular Weight:
311.38
COA:
Inquire
Targets:
Estrogen Receptor/ERR
Description:
DY131 is a novel selective agonist of ERRβ and ERRγ, which displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. It could potentiate the ERRγ-induced growth inhibition in DU145- ERRγ and LNCaP- ERRγ prostate cancer cells in a dose-dependent manner. It inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. It had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). It appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. It has been demonstrated an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.
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Purity:
>99 %
Appearance:
Yellow solid
Synonyms:
N-[(E)-[4-(diethylamino)phenyl]methylideneamino]-4-hydroxybenzamide;GSK4716;GW4716;GW574716;GSK 9089;DY-131
Solubility:
DMSO: ≥14 mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
DY131 has been demonstrated an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Melting Point:
234-236 °C
Density:
1.11±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
WLKOCYWYAWBGKY-CPNJWEJPSA-N
InChI:
InChI=1S/C18H21N3O2/c1-3-21(4-2)16-9-5-14(6-10-16)13-19-20-18(23)15-7-11-17(22)12-8-15/h5-13,22H,3-4H2,1-2H3,(H,20,23)/b19-13+
Canonical SMILES:
CCN(CC)C1=CC=C(C=C1)C=NNC(=O)C2=CC=C(C=C2)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 95167-41-2 DY131

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