|Molecular Formula||C16 H12 O6|
|Description||DW532 is one of simplified analogues of hematoxylin that has been reported to have a broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity. IC50 value for EGFR inhibition was 4.9 μmol/L and for 5.5 μmol/L for VEGFR2 inhibition. It also suppressed their downstream signaling. DW532 inhibited tubulin polymerization dose-dependently via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. Moreover, treatment with DW532 potently and dose-dependently suppressed angiogenesis in vitro and in vivo.|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||579.8±50.0 °C | Condition: Press: 760 Torr|
|Melting Point||176-177 °C|
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