DW532 - CAS 1267949-42-7
Catalog number:
1267949-42-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16 H12 O6
Molecular Weight:
300.26
COA:
Inquire
Targets:
Ser/Thr Protease
Description:
DW532 is one of simplified analogues of hematoxylin that has been reported to have a broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity. IC50 value for EGFR inhibition was 4.9 μmol/L and for 5.5 μmol/L for VEGFR2 inhibition. It also suppressed their downstream signaling. DW532 inhibited tubulin polymerization dose-dependently via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. Moreover, treatment with DW532 potently and dose-dependently suppressed angiogenesis in vitro and in vivo.
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Purity:
98%
Appearance:
Powder
Synonyms:
7,8-dihydroxy-4-(3-hydroxy-4-methoxyphenyl)-2H-chromen-2-one
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
ANTI-CANCER
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
579.8±50.0 °C | Condition: Press: 760 Torr
Melting Point:
176-177 °C
Canonical SMILES:
O=C1C=C(C2=CC=C(OC)C(O)=C2)C3=C(O1)C(O)=C(O)C=C3
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