DuP-697 - CAS 88149-94-4
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
A selective COX-2 inhibitor
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
A selective COX-2 inhibitor
A crystalline solid
Soluble to 100 mM in DMSO
Store at -20°C
Quality Standard:
Canonical SMILES:
1.In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.
Brideau C1, Van Staden C, Chan CC. Am J Vet Res. 2001 Nov;62(11):1755-60.
OBJECTIVE: To determine potency and selectivity of nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase- (COX-) specific inhibitors in whole blood from horses, dogs, and cats.
2.Prenatal effects of DuP-697-the irreversible, highly selective cyclooxygenase-2 inhibitor.
Burdan F1, Dudka J, Szumilo J, Korobowicz A, Klepacz L. Reprod Toxicol. 2003 Jul-Aug;17(4):413-9.
DuP-697 (5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene), like celecoxib and rofecoxib, is a vicinal diaryl heterocycle highly selective cyclooxygenase-2 (COX-2) inhibitor. The aim of the study was to evaluate prenatal tolerability of DuP-697. The drug was administered orally in Tween 80 water suspension once a day to pregnant Wistar rats, on Days 7-18 of gestation. The initial dose, similar to the rat antipyretic dose, was set at 0.05 mg/kg. The middle dose, 3.5 mg/kg, corresponded to the rat anti-inflammatory and analgesic dose. The high dose was set at 35.0 mg/kg. Control animals received Tween 80 water suspension. On Day 21 of gestation, fetuses were delivered by laparotomy and double stained with alcian blue and alizarin red S or examined using the Wilson technique. Intrauterine growth retardation occurred in the groups exposed to the middle and highest dose of DuP-697. Minimal reactive and degenerative hepatic changes were found in both drug-exposed and control groups.
3.Simultaneous quantification of an anti-inflammatory compound (DuP 697) and a potential metabolite (X6882) in human plasma and urine by high-performance liquid chromatography.
Joshi AS1, Raghavan N, Williams RM, Takahashi K, Shingu H, King SY. J Chromatogr B Biomed Appl. 1994 Oct 3;660(1):143-50.
A high-performance liquid chromatographic (HPLC) method using fluorescence detection has been developed for the simultaneous analysis of low nanogram concentrations of an anti-inflammatory drug, 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene (DuP 697), and a potential metabolite (X6882) in human plasma and of DuP 697 in human urine. This assay method used an EM Separations Lichrospher C18 endcapped column. The mobile phase was acetonitrile-water (75:25, v/v). The detection of DuP 697 and X6882 was by fluorescence at excitation and emission wavelengths of 256 and 419 nm, respectively. The chromatographic system could separate DuP 697 from X6882, the external standard (anthracene), and other endogenous substances present in human plasma. In human plasma the limits of quantification for DuP 697 and X6882 were 3 and 20 ng/ml, respectively; the limit of quantification for DuP 697 in human urine was 5 ng/ml. These compounds were shown to be stable in frozen (-20 degrees C) human plasma and urine for at least 9 weeks.
4.Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2,3-diarylthiophenes.
Tsuji K1, Nakamura K, Ogino T, Konishi N, Tojo T, Ochi T, Seki N, Matsuo M. Chem Pharm Bull (Tokyo). 1998 Feb;46(2):279-86.
A series of novel 5-substituted-2,3-diarylthiophenes has been synthesized and found to be active in the rat adjuvant arthritis (AA) model and/or in the yeast-induced hyperalgesia (Randall-Selitto) assay. Among the compounds synthesized herein, 2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)thiop hene (6a) exhibited the most potent activities on AA, collagen-induced arthritis (CIA) and the delayed-type hypersensitivity response to type II collagen. 5-Bromo-2-[4-(methylamino)phenyl]-3-[4-(methylsulfinyl)phenyl]thiophene (38) is also a potent inhibitor of AA, CIA, hyperalgesia and in vitro tumor necrosis factor-alpha production.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Cox-2 Products

CAS 15307-79-6 Diclofenac Sodium

Diclofenac Sodium
(CAS: 15307-79-6)

A non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively

CAS 53-86-1 Indomethacin

(CAS: 53-86-1)

A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively

CAS 169590-42-5 Celecoxib

(CAS: 169590-42-5)

A highly selective COX-2 inhibitor

CAS 220991-20-8 Lumiracoxib

(CAS: 220991-20-8)

A novel, selective COX-2 inhibitor; Phase 4

CAS 40828-46-4 Suprofen

(CAS: 40828-46-4)

A dual COX-1/COX-2 inhibitor

CAS 189954-96-9 Firocoxib

(CAS: 189954-96-9)

A selective COX-2 inhibitor

CAS 202409-33-4 Etoricoxib

(CAS: 202409-33-4)

A selective COX-2 inhibitor

CAS 6385-02-0 Meclofenamate Sodium

Meclofenamate Sodium
(CAS: 6385-02-0)

A dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively

CAS 123653-11-2 NS 398

NS 398
(CAS: 123653-11-2)

A selective COX-2 inhibitor

CAS 70374-39-9 Lornoxicam

(CAS: 70374-39-9)

A non-steroidal COX-1/COX-2 inhibitor; A nonsteroidal anti-inflammatory drug

CAS 53716-49-7 Carprofen

(CAS: 53716-49-7)

A COX-2 inhibitor; A non-steroidal anti-inflammatory drug

CAS 156897-06-2 Licofelone

(CAS: 156897-06-2)

A dual inhibitor of COX-1/COX-2 and 5-LO

COX-2 Inhibitor II
(CAS: 181696-33-3)

A selective inhibitor of Cox-2

CAS 170569-86-5 SC-236

(CAS: 170569-86-5)

A potent, selective COX-2 inhibitor

CAS 198470-85-8 Parecoxib Sodium

Parecoxib Sodium
(CAS: 198470-85-8)

The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells an...

CAS 787623-48-7 COX-2-IN-1

(CAS: 787623-48-7)

A potent and slective COX-2 inhibitor(IC50= 3.9 μM)

CAS 41340-25-4 Etodolac

(CAS: 41340-25-4)

A non-selective inhibitor of COX

CAS 13220-57-0 Tryptanthrin

(CAS: 13220-57-0)

A potent inhibitor of Cox-2, IDO and NOS II

O-Acetyl Salicylhydroxamic Acid
(CAS: 199854-00-7)

An irreversible, non-selective inhibitor of COX-1 and COX-2

CAS 22161-81-5 (S)-Ketoprofen

(CAS: 22161-81-5)

A potent inhibitor of COX-1 and COX-2

Chemical Structure

CAS 88149-94-4 DuP-697

Quick Inquiry

Verification code

Featured Items