Dropropizine - CAS 17692-31-8
Catalog number: 17692-31-8
Category: Inhibitor
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Molecular Formula:
C13H20N2O2
Molecular Weight:
236.31
COA:
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Targets:
Others
Description:
Dropropizine is a racemic non-opiate antitussive agent, it is used as a cough suppressant.Dropropizine exhibits antitussive activity in cats noticeably lower than Pinacidil and Codeine.
Purity:
>98%
Synonyms:
UCB-1967; UCB 1967; UCB1967
MSDS:
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InChIKey:
PTVWPYVOOKLBCG-UHFFFAOYSA-N
InChI:
InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
Canonical SMILES:
C1CN(CCN1CC(CO)O)C2=CC=CC=C2
1.Development and Validation of a Stability-Indicating LC-Method for the Simultaneous Estimation of Levodropropizine, Chloropheniramine, Methylparaben, Propylparaben, and Levodropropizine Impurities.
Kumar PA1, Raju TV, Thirupathi D, Kumar R, Shree J. Sci Pharm. 2013 Mar;81(1):139-50. doi: 10.3797/scipharm.1210-18. Epub 2012 Nov 17.
A simple, fast, and efficient RP-HPLC method has been developed and validated for the simultaneous estimation of Levodropropizine, Chloropheniramine, Methylparaben, Propylparaben, and the quantification of Levodropropizine impurities in the Reswas syrup dosage form. A gradient elution method was used for the separation of all the actives and Levodropropizine impurities by using the X-Bridge C18, 150 mm × 4.6 mm, 3.5 μm column with a flow rate of 1.0 mL/min and detector wavelength at 223 nm. The mobile phase consisted of a potassium dihydrogen orthophosphate buffer and acetonitrile. All the peaks were symmetrical and well-resolved (resolution was greater than 2.5 for any pair of components) with a shorter run time. The limit of detection for Levodropropizine and its Impurity B was 0.07 μg/ml & 0.05 μg/ml, whereas the limit of quantification was 0.19 μg/ml & 0.15 μg/ml respectively. The method was validated in terms of precision, accuracy, linearity, robustness, and specificity.
2.Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.
Luo YL1, Li PB, Zhang CC, Zheng YF, Wang S, Nie YC, Zhang KJ, Su WW. Inflamm Res. 2013 Dec;62(12):1053-61. doi: 10.1007/s00011-013-0664-6. Epub 2013 Oct 2.
OBJECTIVE: The effects of four antitussives, including codeine phosphate (CP), moguisteine, levodropropizine (LVDP) and naringin, on airway neurogenic inflammation and enhanced cough were investigated in guinea pig model of chronic cough.
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CAS 17692-31-8 Dropropizine

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