Dronedarone HCl - CAS 141625-93-6
Catalog number:
141625-93-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C31H44N2O5S.HCl
Molecular Weight:
593.22
COA:
Inquire
Targets:
Others
Description:
Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
SR33589
MSDS:
Inquire
1.Validated HPLC and Ultra-HPLC Methods for Determination of Dronedarone and Amiodarone Application for Counterfeit Drug Analysis.
El-Bagary RI1, Elkady EF, Mowaka S, Attallah M. J AOAC Int. 2015 Nov-Dec;98(6):1496-502. doi: 10.5740/jaoacint.15-054.
Two simple, accurate, and precise chromatographic methods have been developed and validated for the determination of dronedarone (DRO) HCl and amiodarone (AMI) HCl either alone or in binary mixtures due to the possibility of using AMI as a counterfeit of DRO because of its lower price. First, an RP-HPLC method is described for the simultaneous determination of DRO and AMI. Chromatographic separation was achieved on a BDS Hypersil C18 column (150×4.6 mm, 5 μm). Isocratic elution based on potassium dihydrogen phosphate buffer with 0.1% triethylamine pH 6-methanol (10+90, v/v) at a flow rate of 2 mL/min with UV detection at 254 nm was performed. The second method is RP ultra-HPLC in which the chromatographic separation was achieved on an AcclaimTM RSLC 120 C18 column (100×2.1 mm, 2.2 μm) using isocratic elution with potassium dihydrogen phosphate buffer with 0.1% triethylamine pH 6-methanol (5+95, v/v) at a flow rate of 1 mL/min with UV detection at 254 nm.
2.Identification and characterization of stress degradation products of dronedarone hydrochloride employing LC-UV/PDA, LC-MS/TOF and MS(n) studies.
Chadha R1, Bali A2, Bansal G3. J Pharm Biomed Anal. 2016 Jan 25;118:139-48. doi: 10.1016/j.jpba.2015.10.028. Epub 2015 Oct 26.
Dronedarone HCl was subjected to forced decomposition conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH guideline Q1A(R2). The drug showed significant degradation under alkaline hydrolytic and alkaline photolytic conditions while it remained stable in neutral, acidic, thermal and oxidative conditions. In total, six degradation products (I-VI) were formed, which could be separated by chromatography on C18 (250 mm × 4.6 mm; 5 μ, Xterra) column using isocratic elution method. Detection wavelength was selected as 288 nm. Multi-stage (MS(n)) and MS/TOF accurate mass studies were carried out to establish the complete fragmentation pathway of the drug which in turn was utilized in characterization of the products. The degradation pathway of the drug leading to generation of products I-VI was postulated and this has not been reported so far.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CGP-15720 hydrochloride
(CAS: 76692-12-1)

CGP-15720 is a antitumor agent

CAS 69-25-0 Eledoisin

Eledoisin
(CAS: 69-25-0)

Eledoisin is an undecapeptide of mollusk origin and it belongs to the tachykinin family of neuropeptides. It was first isolated from the posterior salivary glan...

CAS 341-69-5 Orphenadrine hydrochloride

Orphenadrine hydrochloride
(CAS: 341-69-5)

A skeletal muscle relaxant used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.

CAS 71320-77-9 Moclobemide

Moclobemide
(CAS: 71320-77-9)

Moclobemide is a reversible monoamine oxidase A (MOA-A) inhibitor.

AMG-126737
(CAS: 224054-76-6)

AMG-126737 is a potent inhibitor of human lung mast cell tryptase (Ki = 90 nM), with greater than 10- to 200-fold selectivity versus other serine proteases.

CAS 60-23-1 Cysteamine

Cysteamine
(CAS: 60-23-1)

Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant. It has been shown to increase intracellular glutathione levels in cystin...

CAS 312756-74-4 RS-1

RS-1
(CAS: 312756-74-4)

RS-1, a cell-permeable sulfonamido-benzamide compound that increases the DNA binding activity of RAD51 (Kd range = 48-107 nM, value depends on cofactors present...

CAS 61303-13-7 Isoacteoside

Isoacteoside
(CAS: 61303-13-7)

Isoacteoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation, compared with those of aminoguanidine and q...

Propagermanium
(CAS: 126595-07-1)

Propagermanium is an organometallic compound of germanium that is sold as an alternative medicine for the treatment of Hepatitis B under the development of Aste...

BMS-192364
(CAS: 202822-21-7)

CAS 172430-46-5 O-Desaryl ranolazine

O-Desaryl ranolazine
(CAS: 172430-46-5)

O-Desaryl Ranolazine, a piperazine derivative, has been found to be a ranolazine metabolite which is a partial fatty acid oxidation inhibitor and could be used ...

CAS 130495-35-1 SKF-96365

SKF-96365
(CAS: 130495-35-1)

SKF-96365, a store-operated Ca2+ entry inhibitor, has been found to restrain the depolarization of circular smooth muscle caused by acetylcholine and also exhib...

CAS 6386-63-6 Cloxyfonac

Cloxyfonac
(CAS: 6386-63-6)

Cloxyfonac is a plant growth regulator and a chemical transformation product.

AM-643
(CAS: 1233114-22-1)

AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB...

CAS 900510-03-4 PF-3274167

PF-3274167
(CAS: 900510-03-4)

PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.

BAY-721973
(CAS: 1380310-94-0)

BAY-721973 is a bio-active chemical,but few detailed information has been published yet.

CAS 11021-14-0 Ginsenoside Rc

Ginsenoside Rc
(CAS: 11021-14-0)

Ginsenoside Rc, a sort of triterpene saponin, is extracted from ginseng and has been found to be antioxidative, anti-aging and has sorts of other properties. It...

CAS 4394-00-7 Niflumic Acid

Niflumic Acid
(CAS: 4394-00-7)

A selective COX-2 inhibitor; GPR35 activator; Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 µM (human); GPR35: IC50 = 1.28 µM (human)

CAS 24584-09-6 Dexrazoxane

Dexrazoxane
(CAS: 24584-09-6)

Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation in...

CAS 1141777-14-1 Emixustat

Emixustat
(CAS: 1141777-14-1)

Emixustat, a novel visual cycle modulator, is a nonretinoid compound that directly inhibits RPE65, but does not bind to RAR/<br/>RXR retinoid receptors or antag...

Chemical Structure

CAS 141625-93-6 Dronedarone  HCl

Quick Inquiry

Verification code

Featured Items