Drevogenin A - CAS 10163-83-4
Catalog number: 10163-83-4
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Drevogenin A is a natural steroid found in the herbs of Dregea volubilis.
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1.Polyoxypregnane glycosides from the flowers of Dregea volubilis.
Sahu N1, Panda N, Mandal N, Banerjee S, Koike K, Nikaido T. Phytochemistry. 2002 Oct;61(4):383-8.
Three novel polyoxypregnane glycosides, volubiloside A, B and C (1-3), were isolated from the flowers of Dregea volubilis Linn., and their structures were elucidated as drevogenin D-3-O-beta-D-glucopyranosyl (1-->4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl (1-->4)-beta-D-cymaropyranosyl (1-->4)-beta-D-cymaropyranoside, drevogenin D-3-O-beta-D-glucopyranosyl (1-->4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl (1-->4)-beta-D-cymaropyranosyl (1-->4)-beta-D-digitoxopyranoside and drevogenin P-3-O-beta-D-glucopyranosyl (1-->4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl (1-->4)-beta-D-cymaropyranosyl (1-->4)-beta-D-cymaropyranoside, respectively, on the basis of extensive NMR experiments, MALDI-TOF MS, and some chemical strategies.
2.[Drevogenin A and Drevogenin B, additional structure proof].
Bhatnagar AS, Stöcklin W, Reichstein T. Helv Chim Acta. 1968;51(1):148-52.
3.[The constituents of C21-steroids from Dregea sinensis var. corrugata].
Jin QD, Mu QZ. Yao Xue Xue Bao. 1989;24(8):587-92.
Drevogenin I, II, two new aglycones, were isolated from Dregea sinensis var. corrugata(Asclepiadaceae). The mass spectrum suggests the presence of two isovaleryl groups. Alkaline hydrolysis of compound I with 5% methanolic potassium hydroxide yielded deacyldrevogenin Ia and isovaleric acid. The acid was esterified with methanol--surfuric acid to afford methyl-isovalerate. By GLC comparison with authentic sample, relative retention time was the same, 1H-NMR shift (delta ppm) and coupling constant were the same, too. On the basis of spectroscopic analysis and chemical reactions, given above the structure of aglycone I was established as C/D cis 5 alpha-H, 3 beta, 8 beta, 14 beta, 17 beta tetrahydroxy-12 beta-O-isovalery1-20-O-isovalerylpregnane. MS molecular weight 552 and elementary analysis were compatible with C31H52O8. The structure of aglycone II was established as C/D cis 5 alpha-H, 3 beta, 14 beta, 17 beta trihydroxy-12 beta-O-acetyl-20-O-benzoyl-pregnane.
4.Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens.
Biju PG1, Rooban BN, Lija Y, Devi VG, Sahasranamam V, Abraham A. Mol Vis. 2007 Jul 12;13:1121-9.
PURPOSE: Selenite-induced cataractogenesis is mediated by oxidative stress, accumulation of calcium and activation of lenticular calpains. Calpains are a super family of Ca2+ dependent proteases, which are involved in lens protein proteolysis and insolubilization. Many inhibitors could prevent calpain-induced proteolysis of alpha- and beta-crystallins in rodent cataracts. Evaluating natural sources with antioxidant property and subsequent prevention of calpain activation may lead to the development of safer and more effective agents against cataractogenesis. There are no reports on the protective role of bioactive components against calpain-mediated proteolysis and subsequent cataractogenesis. The purpose of the study was to evaluate the role of Drevogenin D, a triterpenoid aglycone, isolated from Dregea volubilis in preventing selenite-induced, calcium-activated, calpain-mediated proteolysis in cultured rat lenses.
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CAS 10163-83-4 Drevogenin A

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