Dramamine - CAS 523-87-5
Catalog number: 523-87-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H28ClN5O3
Molecular Weight:
469.97
COA:
Inquire
Targets:
Histamine Receptor
Description:
Dimenhydrinate is an over-the-counter antiemetic used to prevent nausea and motion sicknes composed of 8-Chlorotheophylline and Diphenhydramine.
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Purity:
≥98%
Appearance:
White Solid
Synonyms:
Dimenhydrinate; 2-benzhydryloxy-N,N-dimethylethanamine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Antihistamine with antiemetic properties
Quality Standard:
Enterprise Standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
103-105 °C
InChIKey:
NFLLKCVHYJRNRH-UHFFFAOYSA-N
InChI:
S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)
Canonical SMILES:
CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
1.Environmental risk analysis and prioritization of pharmaceuticals in a developing world context.
Mansour F1, Al-Hindi M2, Saad W1, Salam D3. Sci Total Environ. 2016 Mar 17;557-558:31-43. doi: 10.1016/j.scitotenv.2016.03.023. [Epub ahead of print]
The impact of residual pharmaceuticals on the aquatic environment has gained widespread attention over the past years. Various studies have established the occurrence of pharmaceutical compounds in different water bodies throughout the world. In view of the absence of occurrence data in a number of developing world countries, and given the limited availability of analytical resources in these countries, it is prudent to devise methodologies to prioritize pharmaceuticals for environmental monitoring purposes that are site specific. In this work, several prioritization approaches are used to rank the 88 most commonly consumed pharmaceuticals in Lebanon. A simultaneous multi-criteria decision analysis method utilizing the exposure, persistence, bioaccumulation, and toxicity (EPBT) approach is applied to a smaller subset of the original list (69 pharmaceuticals). Several base cases are investigated and sensitivity analysis is applied to one of these base case runs.
2.Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method.
Belal TS1, Abdel-Hay KM2, Clark CR3. J Adv Res. 2016 Jan;7(1):53-8. doi: 10.1016/j.jare.2015.01.010. Epub 2015 Feb 7.
A novel simple, direct and selective gas chromatography-mass spectrometry (GC/MS) procedure was developed for the determination of the antihistamine drug dimenhydrinate (DMH) in presence of six of its related substances and potential impurities, namely, diphenylmethane, diphenylmethanol, benzophenone, orphenadrine, caffeine and 8-chlorocaffeine. The method involved resolution of the underivatized compounds using a trifluoropropylmethyl polysiloxane (Rtx-200) capillary column and the mass spectrometric detection was carried out in the electron-impact (EI) mode. Excellent baseline separation of DMH and the cited related substances was achieved in less than 15 min. Quantification of the parent drug DMH was based on measuring its peak area. The reliability and analytical performance of the proposed method were validated with respect to linearity, range, precision, accuracy, specificity, robustness, detection and quantification limits. Calibration curve of DMH was linear over the range 50-500 μg/mL with determination coefficient (R (2)) = 0.
3.The Safety of Drug Therapy in Children.
Wimmer S1, Neubert A, Rascher W. Dtsch Arztebl Int. 2015 Nov 13;112(45):781-7. doi: 10.3238/arztebl.2015.0781.
BACKGROUND: 1.7% of children taking medication on an outpatient basis in Germany have at least one adverse drug reaction (ADR). The corresponding figure for hospitalized children is estimated at 10% .
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CAS 523-87-5 Dramamine

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