Doxylamine-d5 succinate - CAS 1216840-94-6
Category: Labelled APIs
Molecular Formula:
C17H17D5N2O·C4H6O4
Molecular Weight:
393.49
COA:
Inquire
Tag:
Others
Description:
The succinate salt form of isotope labelled Doxylamine, a histamine receptor antagonist, could be used as a sedative and hypnotic.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Related CAS:
562-10-7 (unlabelled)
Appearance:
Off-White Solid
Synonyms:
N,N-Dimethyl-2-[1-(phenyl-d5)-1-(2-pyridinyl)ethoxy]ethanamine
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The succinate salt form of isotope labelled Doxylamine.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
SXAPWGVGMOSGBF-UHFFFAOYSA-N
InChI:
InChI=1S/C22H43NO4/c1-4-5-6-14-17-22(23(26)21(2,3)19-27-22)18-15-12-10-8-7-9-11-13-16-20(24)25/h26H,4-19H2,1-3H3,(H,24,25)
Canonical SMILES:
CCCCCCC1(N(C(CO1)(C)C)O)CCCCCCCCCCC(=O)O
1.The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?
Badr DM1, Hafez HF1, Agha AM2, Shouman SA1. Oxid Med Cell Longev. 2016;2016:4741694. doi: 10.1155/2016/4741694. Epub 2016 Mar 29.
α-Tocopheryl succinate (α-TOS), a mitochondria-targeting agent, induces apoptosis in malignant cells in vitro and in vivo. Selenite is a nutritional supplement that has been shown to stimulate apoptosis in cancer cells. This study was designed to investigate the cytotoxic effect of combined treatment of α-TOS and sodium selenite (SSe) in vitro and in vivo and to explore their effect on apoptosis and autophagy in breast cancer. The type of interaction between α-TOS and SSe was evaluated and levels of oxidative stress and apoptotic and autophagic markers were determined. SSe alone showed varying degrees of cytotoxicity on all the tested cell lines. Its combination with α-TOS was antagonistic in vitro in MCF7 and in vivo in mice bearing Ehrlich tumor compared to α-TOS-treated one. Combination of TOS with 2 μM of SSe increased the level of glutathione without changes in antiapoptotic markers Bcl-2 and Mcl-1 at 16 and 48 hrs. SSe decreased caspase 3 activity and protein level of caspases 7 and 9, while it increased autophagic markers beclin-1 and LC3B protein levels of MCF7 cells treated with α-TOS.
2.3-Bromopyruvic Acid Inhibits Tricarboxylic Acid Cycle and Glutaminolysis in HepG2 Cells.
Jardim-Messeder D1, Moreira-Pacheco F2. Anticancer Res. 2016 May;36(5):2233-41.
BACKGROUND/AIM: 3-bromopyruvate (3BrPA) is an antitumor agent able to inhibit aerobic glycolysis and oxidative phosphorylation, therefore inducing cell death. However, cancer cells are also highly dependent of glutaminolysis and tricarboxylic acid cycle (TCA) regarding survival and 3BrPA action in these metabolic routes is poorly understood.
3.Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy.
Kruspig B1, Valter K1, Skender B2, Zhivotovsky B3, Gogvadze V4. Biochim Biophys Acta. 2016 Apr 29. pii: S0167-4889(16)30126-4. doi: 10.1016/j.bbamcr.2016.04.026. [Epub ahead of print]
Mitochondria play a pivotal role in apoptosis: permeabilization of the outer mitochondrial membrane and the release of pro-apoptotic proteins from the intermembrane space of mitochondria are regarded as the key event in apoptosis induction. Here we demonstrate how non-toxic doses of the mitochondrial Complex II inhibitor thenoyltrifluoroacetone (TTFA), which specifically inhibits the ubiquinone-binding site of succinate dehydrogenase (SDH), synergistically stimulated cell death, induced by harmless doses of cisplatin in a panel of chemoresistant neuroblastoma cell lines. Apoptotic cell death was confirmed by cytochrome c release from the mitochondria, cleavage of poly ADP-ribose polymerase, processing of caspase-3, which is an important executive enzyme in apoptosis, and caspase-3-like activity. Methyl malonate, an inhibitor of the SDHA subunit partially reversed apoptosis stimulated by TTFA in SK-N-BE(2) neuroblastoma cells (NB), indicating that sensitization requires oxidation of succinate.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 345909-96-8 Cefoperazone-d3

Cefoperazone-d3
(CAS: 345909-96-8)

Cefoperazone-d3 is a labelled cefoperazone. Cefoperazone is a cephalosporin antibiotic specifically used for Pseudomonas bacterial infections resistant to other...

Riluzole-13C-15N2
(CAS: 1215552-03-6)

A labelled Riluzole, a neuroprotective agent that modulates glutamatergic transmission. It is a glutamate release inhibitor and an anticonvulsant.

Huperzine A-d3

Huperzine A-d3 is a labelled Huperzine A. Huperzine A is a naturally occurring sesquiterpene alkaloid used for the treatment of swelling, fever, blood disorders...

Mecoprop-D6

Mecoprop-D6 is a labelled Mecoprop. Mecoprop is an herbicide commonly used for control of broadleaf weeds.

Oltipraz-d3

An isotope labelled of Oltipraz. Oltipraz is a schistosomicide.

Alverine-d5 Citrate
(CAS: 1215327-00-6)

A labelled Alverine Citrate. Alverine Citrate is used as a smooth muscle relaxant.

Metaxalone-d6
(CAS: 1189944-95-3)

Metaxalone-d6 is a labelled Metaxalone. Metaxalone is used as a muscle relaxant.

Manidipine-d4
(CAS: 1189656-59-4)

Manidipine-d4 is a labelled Manidipine. Manidipine is a calcium channel blocker used as an antihypertensive.

CAS 185056-83-1 Coumarin-d4

Coumarin-d4
(CAS: 185056-83-1)

Coumarin-d4 is the labelled Coumarin. Coumarin is a chemical compound found in many plants with an anticoagulant activity.

CAS 1133229-30-7 Levetiracetam-d6

Levetiracetam-d6
(CAS: 1133229-30-7)

The labelled (S)-enantiomer of the ethyl analog of Piracetam

CAS 132183-78-9 Carbamazepine-d10

Carbamazepine-d10
(CAS: 132183-78-9)

A labelled Carbamazepine, intended for use as an internal standard for the quantification of Carbamazepine by GC- or LC-mass spectrometry.

Bosentan-d4
(CAS: 1065472-77-6)

Bosentan-d4 is a labelled Bosentan. Bosentan is an endothelin receptor antagonist indicated for pulmonary artery hypertension (PAH).

Flunisolide-d6

An isotope labelled of Flunisolide. Flunisolide is a corticosteroid that can be used for the treatment for allergic rhinitis.

Bupivacaine-d9
(CAS: 47668-57-0)

Bupivacaine-d9 is a labelled Bupivacaine. Bupivacaine is a local anesthetic.

Sulfisoxazole-13C6
(CAS: 1334378-46-9)

Sulfisoxazole-13C6 is a labelled Sulfisoxazole. Sulfisoxazole is an antibiotic against both Gram-negative and Gram-positive organisms.

Raloxifene-d4 HCl
(CAS: 1188263-47-9)

An isotope labelled Raloxifene. Raloxifene is selective estrogen receptor modulator. It can be used in the prevention of osteoporosis in postmenopausal women an...

Ruxolitinib-d4

A deuterated ruxolitinib. Ruxolitinib is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelo...

Norgestrel-d6

A labelled Norgestrel. Norgestrel is an excellent progestational and ovulation inhibiting steroid.

Mifepristone-d6

Mifepristone-d6 is a labelled progesterone receptor antagonist with partial agonist activity.

Dutasteride-13C6
(CAS: 1217685-27-2)

A labelled Dutasteride. Dutasteride is a triple 5α-reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone.

Quick Inquiry

Verification code

Featured Items