Doxercalciferol - CAS 54573-75-0
Catalog number: 54573-75-0
Category: Inhibitor
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Molecular Formula:
C28H44O2
Molecular Weight:
412.65
COA:
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Targets:
VD/VDR
Description:
Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2) is a synthetic analog of vitamin D; is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).
Purity:
0.98
Synonyms:
Hectorol; 1.alpha.-Hydroxyvitamin D2.
MSDS:
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InChIKey:
HKXBNHCUPKIYDM-CGMHZMFXSA-N
InChI:
InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
Canonical SMILES:
CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
1.Calcium regulates FGF-23 expression in bone.
David V1, Dai B, Martin A, Huang J, Han X, Quarles LD. Endocrinology. 2013 Dec;154(12):4469-82. doi: 10.1210/en.2013-1627. Epub 2013 Oct 18.
Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone. To better understand the regulation of FGF-23 by calcium, phosphorus, 1,25 dihydroxyvitamin D3 [1,25(OH)2D], and PTH, we examined FGF-23 expression under basal conditions and in response to PTH, doxercalciferol, or high-calcium diet treatment in Gcm2(-/-) and Cyp27b1(-/-) mutant mice. Gcm2(-/-) mice exhibited low serum PTH and 1,25(OH)2D concentrations, hypocalcemia, and hyperphosphatemia, whereas Cyp27b1(-/-) mice had high PTH, undetectable 1,25(OH)2D, hypocalcemia, and hypophosphatemia. Serum FGF-23 levels were decreased in both mutant models. Doxercalciferol administration increased serum FGF-23 levels in both mutant models. PTH administration to Gcm2(-/-) mice also increased serum FGF-23 levels, in association with an increase in both 1,25(OH)2D and calcium concentrations. Multiple regression analysis of pooled data indicated that changes in FGF-23 were positively correlated with serum calcium and 1,25(OH)2D but not related to changes in serum phosphate concentrations.
2.Effect of Vitamin D Receptor Activators on Glomerular Filtration Rate: A Meta-Analysis and Systematic Review.
Zhang Q1, Li M2, Zhang T3, Chen J4. PLoS One. 2016 Jan 26;11(1):e0147347. doi: 10.1371/journal.pone.0147347. eCollection 2016.
BACKGROUND: Vitamin D receptor activators (VDRAs) can protect against mineral bone disease, but they are reported to elevate serum creatinine (SCr) and may also reduce glomerular filtration rate (GFR).
3.Interventions for metabolic bone disease in children with chronic kidney disease.
Hahn D1, Hodson EM, Craig JC. Cochrane Database Syst Rev. 2015 Nov 12;11:CD008327. doi: 10.1002/14651858.CD008327.pub2.
BACKGROUND: Bone disease is common in children with chronic kidney disease (CKD) and when untreated may result in bone deformities, bone pain, fractures and reduced growth rates. This is an update of a review first published in 2010.
4.Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients.
Pereira RC1, Jüppner H2, Gales B1, Salusky IB1, Wesseling-Perry K1. PLoS One. 2015 Mar 16;10(3):e0120856. doi: 10.1371/journal.pone.0120856. eCollection 2015.
BACKGROUND: Osteocytic protein expression is dysregulated in CKD and is affected by changes in mineral metabolism; however the effects of active vitamin D sterol therapy on osteocyte protein expression in advanced CKD is unknown.
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