Doxercalciferol - CAS 54573-75-0
Catalog number: 54573-75-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
VD/VDR
Description:
Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2) is a synthetic analog of vitamin D; is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).
Publictions citing BOC Sciences Products
  • >> More
Purity:
0.98
Synonyms:
Hectorol; 1.alpha.-Hydroxyvitamin D2.
MSDS:
Inquire
1.Calcium regulates FGF-23 expression in bone.
David V1, Dai B, Martin A, Huang J, Han X, Quarles LD. Endocrinology. 2013 Dec;154(12):4469-82. doi: 10.1210/en.2013-1627. Epub 2013 Oct 18.
Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone. To better understand the regulation of FGF-23 by calcium, phosphorus, 1,25 dihydroxyvitamin D3 [1,25(OH)2D], and PTH, we examined FGF-23 expression under basal conditions and in response to PTH, doxercalciferol, or high-calcium diet treatment in Gcm2(-/-) and Cyp27b1(-/-) mutant mice. Gcm2(-/-) mice exhibited low serum PTH and 1,25(OH)2D concentrations, hypocalcemia, and hyperphosphatemia, whereas Cyp27b1(-/-) mice had high PTH, undetectable 1,25(OH)2D, hypocalcemia, and hypophosphatemia. Serum FGF-23 levels were decreased in both mutant models. Doxercalciferol administration increased serum FGF-23 levels in both mutant models. PTH administration to Gcm2(-/-) mice also increased serum FGF-23 levels, in association with an increase in both 1,25(OH)2D and calcium concentrations. Multiple regression analysis of pooled data indicated that changes in FGF-23 were positively correlated with serum calcium and 1,25(OH)2D but not related to changes in serum phosphate concentrations.
2.Effect of Vitamin D Receptor Activators on Glomerular Filtration Rate: A Meta-Analysis and Systematic Review.
Zhang Q1, Li M2, Zhang T3, Chen J4. PLoS One. 2016 Jan 26;11(1):e0147347. doi: 10.1371/journal.pone.0147347. eCollection 2016.
BACKGROUND: Vitamin D receptor activators (VDRAs) can protect against mineral bone disease, but they are reported to elevate serum creatinine (SCr) and may also reduce glomerular filtration rate (GFR).
3.Interventions for metabolic bone disease in children with chronic kidney disease.
Hahn D1, Hodson EM, Craig JC. Cochrane Database Syst Rev. 2015 Nov 12;11:CD008327. doi: 10.1002/14651858.CD008327.pub2.
BACKGROUND: Bone disease is common in children with chronic kidney disease (CKD) and when untreated may result in bone deformities, bone pain, fractures and reduced growth rates. This is an update of a review first published in 2010.
4.Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients.
Pereira RC1, Jüppner H2, Gales B1, Salusky IB1, Wesseling-Perry K1. PLoS One. 2015 Mar 16;10(3):e0120856. doi: 10.1371/journal.pone.0120856. eCollection 2015.
BACKGROUND: Osteocytic protein expression is dysregulated in CKD and is affected by changes in mineral metabolism; however the effects of active vitamin D sterol therapy on osteocyte protein expression in advanced CKD is unknown.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related VD/VDR Products


CAS 86307-44-0 Impurity C of Calcitriol

Impurity C of Calcitriol
(CAS: 86307-44-0)

Impurity C of Calcitriol is the impurity C of Calcitriol, which is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

CAS 41294-56-8 Alfacalcidol

Alfacalcidol
(CAS: 41294-56-8)

A synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption an...

CAS 32222-06-3 Calcitriol

Calcitriol
(CAS: 32222-06-3)

Calcitriol is the hormonally active form of vitamin D.

CAS 147657-22-5 Calcipotriol monohydrate

Calcipotriol monohydrate
(CAS: 147657-22-5)

Calcipotriol increased hCAP18 mRNA expression in IL-17/IL-22-stimulated keratinocytes. However, LL37 peptide in the culture supernatants was reduced by calcipot...

CAS 131918-61-1 Paricalcitol

Paricalcitol
(CAS: 131918-61-1)

Synthetic analog of vitamin D. Antihyperparathyroid.

CAS 50-14-6 Vitamin D2

Vitamin D2
(CAS: 50-14-6)

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

CAS 55721-11-4 Secalciferol

Secalciferol
(CAS: 55721-11-4)

Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. lt mediates calcium and phosphorus homeo...

CAS 58050-55-8 24, 25-Dihydroxy VD2

24, 25-Dihydroxy VD2
(CAS: 58050-55-8)

24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2, which is a synthetic analog of Vitamin D.

CAS 112828-09-8 (24R)-MC 976

(24R)-MC 976
(CAS: 112828-09-8)

(24R)-MC 976 is a Vitamin D3 derivative.

CAS 60133-18-8 Ercalcitriol

Ercalcitriol
(CAS: 60133-18-8)

Ercalcitriol is a active metabolite of vitamin D2. It exhibits equipotent antirachitic activity in rats as calcitriol.

CAS 82266-85-1 Impurity C of Alfacalcidol

Impurity C of Alfacalcidol
(CAS: 82266-85-1)

Impurity C of Alfacalcidol is impurity of Alfacalcidol, which is a non-selective VDR activator medication. Alfacalcidol improves mechanical bone strength and bo...

CAS 55700-58-8 (24S)-24,25-Dihydroxyvitamin D3

(24S)-24,25-Dihydroxyvitamin D3
(CAS: 55700-58-8)

(24S)-24,25-Dihydroxycholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.

CAS 511-28-4 Vitamin D4

Vitamin D4
(CAS: 511-28-4)

Vitamin D4 is the active analogue of Vitamin D.

CAS 103656-40-2 Calcitriol Impurities D

Calcitriol Impurities D
(CAS: 103656-40-2)

One of the impurities of Calcitriol, an active metabolite of VD3, could be a agonist of vitamin D receptor.

CAS 112875-61-3 Impurity of Calcipotriol

Impurity of Calcipotriol
(CAS: 112875-61-3)

Impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

CAS 57333-96-7 Tacalcitol

Tacalcitol
(CAS: 57333-96-7)

Tacalcitol promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes. lt induces nerve growth factor product...

CAS 134404-52-7 Seocalcitol

Seocalcitol
(CAS: 134404-52-7)

Seocalcitol is a vitamin D receptor (VDR) agonist. Seocalcitol exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects

CAS 199798-84-0 BXL 628

BXL 628
(CAS: 199798-84-0)

BXL 628 is a vitamin D3 analogue that competes with vitamin D receptor (VDR) for inhibition of prostate cell growth and RhoA/Rho-kinase signaling, a calcium sen...

CAS 131875-08-6 Lexacalcitol

Lexacalcitol
(CAS: 131875-08-6)

KH1060 metabolism could be blocked by the cytochrome P450 inhibitor, ketoconazole. KH1060 was not an effective competitor of C24 oxidation of 1alpha,25-(OH)2D3....

CAS 21343-40-8 Ercalcidiol

Ercalcidiol
(CAS: 21343-40-8)

A metabolite of Vitamin D2

Chemical Structure

CAS 54573-75-0 Doxercalciferol

Quick Inquiry

Verification code

Featured Items