Doxapram HCl - CAS 7081-53-0
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Not Intended for Therapeutic Use. For research use only.
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Potassium Channel
Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
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B0084-097383 200 mg $169 In stock
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1.New role for FDA-approved drugs in combating antibiotic-resistant bacteria.
Andersson JA1, Fitts EC2, Kirtley ML2, Ponnusamy D2, Peniche AG3, Dann SM4, Motin VL5, Chauhan S1, Rosenzweig JA6, Sha J7, Chopra AK8. Antimicrob Agents Chemother. 2016 Apr 11. pii: AAC.00326-16. [Epub ahead of print]
Antibiotic resistance in medically relevant bacterial pathogens, coupled with a paucity of novel anti-microbial discoveries, represents a pressing global crisis. Traditional drug discovery is an inefficient and costly process; however, systematic screening of Food and Drug Administration (FDA)-approved therapeutics for other indications in humans offers a rapid alternative approach. In this study, we screened a library of 780 FDA-approved drugs to identify molecules that rendered RAW 264.7 murine macrophages resistant to cytotoxicity induced by the highly virulentYersinia pestisCO92 strain. Of these compounds, we identified 94, not classified as antibiotics, as being effective in preventingY. pestis-induced cytotoxicity. A total of 17 "down-selected" drugs, based on efficacy inin vitroscreens, were chosen for further evaluation in a murine model of pneumonic plague to delineate ifin vitroefficacy could be translatedin vivo Three drugs, doxapram (DXP), amoxapine (AXPN), and trifluoperazine (TFP), increased animal survivability despite not exhibiting any direct bacteriostatic or bactericidal effect onY.
2.Observational Study on Less Invasive Surfactant Administration (LISA) in Preterm Infants<29 Weeks - Short and Long-term Outcomes.
Teig N1, Weitkämper A1, Rothermel J1, Bigge N1, Lilienthal E1, Rossler L1, Hamelmann E1. Z Geburtshilfe Neonatol. 2015 Dec;219(6):266-273. Epub 2015 Nov 9.
Background: A recent trial has demonstrated short-term benefits of a new minimal invasive procedure of surfactant administration in spontaneously breathing preterm infants ≥26 weeks (less invasive surfactant administration, LISA). Aim: To assess safety as well as short- and long-term outcomes of the LISA procedure in preterm infants between 23-28 weeks of gestation. Study design: Preterm infants born between 23+0 and 28+6 weeks gestational age during 2 periods, 18 months before (Period 1, n=44) and 18 months after introduction of LISA (Period 2, n=53), were analyzed for neonatal outcomes. 52% of discharged infants were assessed for neurodevelopmental outcome at corrected age of 3 years. Results: In Period 2, 66% of the preterm infants needing surfactant were treated by the new method of LISA. In this period, fewer patient had to be ventilated during the first 3 days of life (42 vs. 77%, p<0.0005) and overall (55 vs. 77%, p=0.02). The median duration of mechanical ventilation was 2 vs.
3.An Impedance-Based Model for the Assessment of Cardiopulmonary Function in Rabbits.
Horsmon MS1, Vincelli NM2, Taylor JT2, Kristovich RL3. J Am Assoc Lab Anim Sci. 2016;55(2):213-20.
Improving the quality of physiologic data collected from research animals is most easily accomplished by collecting as much information as possible from a single subject, thereby reducing animal use and error associated with satellite groups. We investigated the feasibility of using a large-animal implantable telemetry device in New Zealand white rabbits (n = 6). The first task was to develop an implantation technique that yielded calibrated tidal volume (Vt) measurements that were within 10% of those obtained simultaneously from a pneumotachograph, a low-noise electrocardiogram, and stable blood pressure. The second task was to challenge implanted rabbits with the respiratory stimulant doxapram to assess linearity of the calibration across a range of Vt. Of the 3 electrode placements attempted, only one resulted in calibrations consistently below 10% error. Optimal electrode placement resulted in calibrated Vt measurements within 1.7% ± 0.
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CAS 7081-53-0 Doxapram HCl

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