Dovitinib lactate - CAS 692737-80-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C24H27FN6O4
Molecular Weight:
482.51
COA:
Inquire
Targets:
FGFR
Description:
Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, RET, TrKA, and FLT3, and additionally targets FGFR (IC50= 5 nM).
Brife Description:
A potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50= 5 nM)
Synonyms:
4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one;2-hydroxypropanoic acid; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate; Dovitinib(lactate); 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxy; CTK8B6779
Solubility:
DMSO: ≥ 30 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
InChIKey:
CGMQRWDUAUFVEO-UHFFFAOYSA-N
InChI:
1S/C21H21FN6O.C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6/h2-6,11,24-25H,7-10,23H2,1H3;2,4H,1H3,(H,5,6)
Canonical SMILES:
CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related FGFR Products


CAS 1707289-21-1 BLU-554

BLU-554
(CAS: 1707289-21-1)

BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of h...

CAS 1708971-55-4 FGF-401

FGF-401
(CAS: 1708971-55-4)

FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50= 1.9 nM) developed for the treatment of solid tumor.

CAS 192705-80-9 PD-161570

PD-161570
(CAS: 192705-80-9)

PD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinase...

CAS 1538604-68-0 BLU9931

BLU9931
(CAS: 1538604-68-0)

BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 si...

CAS 656247-17-5 Nintedanib

Nintedanib
(CAS: 656247-17-5)

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59...

CAS 1058137-23-7 Lucitanib

Lucitanib
(CAS: 1058137-23-7)

Lucitanib, also known as E-3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor re...

CAS 102586-30-1 NSC12

NSC12
(CAS: 102586-30-1)

NSC12 is an extracellular trap for fibroblast growth factor 2 (FGF2). It binds FGF2 with Kd value of 51 µM and interferes with its interaction with FGFR1 withou...

CAS 848463-13-8 SSR128129E free acid

SSR128129E free acid
(CAS: 848463-13-8)

SSR128129E free acid is a multi-FGFR blocker with allosteric properties. It inhibits FGFR signaling by binding to the extracellular FGFR domain without affectin...

Chemical Structure

CAS 692737-80-7 Dovitinib lactate

Quick Inquiry

Verification code

Featured Items