|Description||Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.|
|Synonyms||L671152; MK507; Trusopt|
BMS-188494 is the prodrug of BMS-187745, a squalene synthase inhibitor used as an anticholesterol drug.
Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on. Taxifolin has shown to inhibit the ovarian cancer cel...
Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitron...
PKR-IN-2 is a pyruvate kinase (PKR) activator. IC50: PKR (R510Q) ＜100 nM
Angelicin is a furanocoumarin isolated from P. corylifolia might be a potential new agent for prevention of inflammatory reactions.
Crystal violet is a triarylmethane dye.
Exogenous H2S, as we know, has anti-inflammatory effects both in macrophages and in animal models. FW1256 is a slow release H2S dononr and it is much more poten...
Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM.
Bucladesine sodium salt
Bucladesine is a cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cyclic adenosine monophosphate (cAMP) and is a phosphodiester...
The hydrochloride salt form of Lotrafiban, a benzodiazepine derivative, has been found to be a platelet glycoprotein IIb/IIIa blocker and was once studied in ca...
Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.
A potent inhibitor of protein tyrosine kinase (PTK)
PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. DprE1 is an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The...
Duloxetine metabolite Para-Naphthol Dulo
Duloxetine metabolite Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor.
Emiglitate is an α-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release.But no development was reported for the treatment of Di...
Trichloromethane is a solvent, as a powerful blister agent used for chemical warfare.
AM-156 is a bio-active chemical and detailed information has not been published yet.
A802715, a methylxanthine derivative, is an anti-tumor agent with a TD50 (toxic dose of 50%) of 0.9-1.1 mM.
Collagen proline hydroxylase inhibitor-1
Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.