Dorzolamide - CAS 120279-96-1
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Not Intended for Therapeutic Use. For research use only.
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Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
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L671152; MK507; Trusopt
1.Effect of Antiglaucoma Medicine on Intraocular Pressure in DBA/2J Mice.
Sawada K1, Hiraoka M, Ohguro H. Ophthalmic Res. 2016;55(4):205-11. doi: 10.1159/000444057. Epub 2016 Mar 5.
BACKGROUND: The DBA/2J mouse strain is known to develop glaucomatous changes. Intraocular pressure (IOP) fluctuations affected by age or antiglaucoma drug administration were compared among three mouse strains, DBA/2J, C57BL/6, and BALB/c.
2.Keratoprosthesis in pediatric keratitis-icthyosiform-deafness syndrome.
Brown C1, Rowlands M2, Lee D2, Geffin JA3, Huang J2. J AAPOS. 2016 Feb;20(1):73-5. doi: 10.1016/j.jaapos.2015.09.009.
We report the first case of Boston Keratoprosthesis (KPro) implantation in a 7-year-old girl with keratitis-ichthyosiform-deafness syndrome and persistent, highly vascular corneal surface disease. An adult aphakic KPro with 8.5 mm backplate was implanted successfully and without operative or postoperative complications following 3 failed penetrating keratoplasties. Visual acuity improved from hand motions to 20/70 in the left eye 22 months after KPro surgery and from hand motion to hand motion with direction in the right eye. Glaucoma developed in the left eye, but intraocular pressure was successfully controlled with Ahmed valve placement and topical dorzolamide-timolol.
3.Efficacy of Bimatoprost Plus Timolol Fixed Combination in Open Angle Glaucoma Patients Previously Treated with Dorzolamide Plus Timolol Fixed Combination.
Sacchi M1, Specchia C2,3, Williams SE4, Villani E1, Nucci P1. Curr Eye Res. 2016 Apr 26:1-5. [Epub ahead of print]
PURPOSE: To evaluate the efficacy and safety of bimatoprost plus timolol fixed combination (BTFC) in patients with primary open angle glaucoma (POAG) previously treated with dorzolamide plus timolol fixed combination (DTFC).
4.Acute Corneal Toxicity of Combined Antiglaucoma Topical Eyedrops.
Mohamed YH1,2, Uematsu M1, Onizuka N1, Ueki R1, Inoue D1, Fujikawa A1, Sasaki H3, Kitaoka T1. Curr Eye Res. 2016 Mar 22:1-5. [Epub ahead of print]
PURPOSE: To investigate the corneal toxicity of three combined antiglaucoma topical eyedrops using transepithelial electrical resistance (TER) and scanning electron microscopy (SEM).
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CAS 120279-96-1 Dorzolamide

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