Domperidone - CAS 57808-66-9
Catalog number: 57808-66-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H24ClN5O2
Molecular Weight:
425.91
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Domperidone is a medication developed by Janssen Pharmaceutica that acts as a peripherally-selective antagonist of the dopamine D2 and D3 receptors.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Drugs with potential cardiac adverse effects: Retrospective study in a large cohort of parkinsonian patients.
Heranval A1, Lefaucheur R1, Fetter D1, Rouillé A1, Le Goff F1, Maltête D2. Rev Neurol (Paris). 2016 Apr 7. pii: S0035-3787(16)00431-8. doi: 10.1016/j.neurol.2015.11.007. [Epub ahead of print]
INTRODUCTION/OBJECTIVE: Drugs with potential cardiac adverse effects are commonly prescribed in Parkinson's disease (PD). To describe demographic and clinical characteristics in a group of PD patients with cardiac events and to evaluate risk factors.
2.Formulation development and evaluation of medicated chewing gum of anti-emetic drug.
Paradkar M1, Gajra B1, Patel B2. Saudi Pharm J. 2016 Mar;24(2):153-64. doi: 10.1016/j.jsps.2015.02.017. Epub 2015 Apr 3.
CONTEXT: Medicated chewing gum (MCG) of Domperidone Maleate (DM) was developed by direct compression method with the goal to achieve quick onset of action and to improve patient compliance.
3.Characteristics and Functional Roles of Opioids Originally Present in Vivo.
Ozaki M1. Yakugaku Zasshi. 2016;136(4):591-605. doi: 10.1248/yakushi.15-00265.
The characteristics and functional roles of opioids originally present in vivo (endogenous opioids) in guinea-pig ileum were investigated. The release of endogenous opioids was determined by the inhibitory twitch response evoked by 0.1 Hz stimulation after 10 Hz stimulation (post-tetanic twitch inhibition). The effects of peptidase inhibitors increased the post-tetanic twitch inhibition, prevented by β-funaltrexamine and nor-binaltorphimine, which are selective μ- and κ-opioid receptor subtype antagonists, respectively. Dopamine receptor antagonists (haloperidol, sultopride and domperidone) increased the post-tetanic twitch inhibition. These results suggest that dopamine receptors are involved in modulation of the ileal opioid system, so as to diminish endogenous opioid release by tetanic stimulation, and dopamine antagonists increase the opioid action, that might depend more on the increased release of endogenous opioids. The post-tetanic twitch inhibition was inhibited by adrenalectomy, and showed the supersensitivity of the opioid receptors, resulting from a decrease of endogenous opioids by adrenalectomy.
4.Effects of the fish spawning inducer ovaprim on vasotocin receptor gene expression in brain and ovary of the catfish Heteropneustes fossilis with a note on differential transcript expression in ovarian follicles.
Rawat A1, Chaube R1, Joy KP2. Gen Comp Endocrinol. 2016 Mar 7. pii: S0016-6480(16)30046-6. doi: 10.1016/j.ygcen.2016.03.002. [Epub ahead of print]
Ovaprim (OVP), a commercial formulation of a salmon GnRH analogue and the dopamine receptor-2 blocker domperidone, is a successful spawning inducer for fish breeding. It induces a preovulatory surge in LH, which stimulates the synthesis of a maturation-inducing steroid (MIS, 17,20β-dihydroxy-4-pregnen-3-one) that initiates germinal vesicle breakdown (GVBD) and ovulation. Coincidently, the OVP treatment also stimulates vasotocin (VT) secretion in the brain and ovary of the catfish Heteropneustes fossilis that also stimulates the synthesis of the MIS. VT mediates its effect through V1- and V2-type receptors. In the present study in the catfish, we report that OVP stimulates the expression of VT receptor genes v1a1, v1a2 and v2a in the brain and ovary. A single intraperitoneal administration of OVP (0.5μL/g body weight) or incubation of post-vitellogenic ovarian follicles with 5μL/mL OVP, for 0, 4, 8, 12, 16, and 24h stimulated ovulation and GVBD, respectively, in a time-dependent manner.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dopamine Receptor Products


CAS 69-23-8 Fluphenazine

Fluphenazine
(CAS: 69-23-8)

Fluphenazine, sold under the brand names Prolixin

CAS 7416-34-4 Molindone

Molindone
(CAS: 7416-34-4)

Molindone is dopamine D2 receptor antagonist which can be used in the treatment of schizophrenia. Molindone can block the effects of dopamine in the brain, lead...

CAS 91374-20-8 Ropinirole HCl

Ropinirole HCl
(CAS: 91374-20-8)

Ropinirole a selective D-2 agonist with Ki of 29 nM.

CAS 4093-35-0 Bromopride

Bromopride
(CAS: 4093-35-0)

Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.

CAS 15622-65-8 Molindone hydrochloride

Molindone hydrochloride
(CAS: 15622-65-8)

Molindone hydrochloride, an indole derivative, as an antipsychotic agent it blocks the effects of dopamine in the brain which can be used for the treatment of s...

CAS 182210-74-8 (S)-5-Hydroxy-DPAT hydrobromide

(S)-5-Hydroxy-DPAT hydrobromide
(CAS: 182210-74-8)

A potent and selective dopamine (DA) D2 receptor agonist.

CAS 123240-93-7 R(-)-N-Ethylnorapomorphine hydrochloride

R(-)-N-Ethylnorapomorphine hydrochloride
(CAS: 123240-93-7)

R(-)-N-Ethylnorapomorphine hydrochloride is a dopamine D2 receptor agonist.

CAS 871351-61-0 Piperidine-MO-1

Piperidine-MO-1
(CAS: 871351-61-0)

A modulator of dopamine receptor

CAS 24526-64-5 Nomifensine

Nomifensine
(CAS: 24526-64-5)

Nomifensine, also called as Hoe 984 or Linamiphen, as a norepinephrine-dopamine reuptake inhibitor it is an antidepressant drug but due to increased incidence o...

CAS 67227-57-0 Fenoldopam Mesylate

Fenoldopam Mesylate
(CAS: 67227-57-0)

Fenoldopam is a selective D1 receptor partial agonist, binds to α2-adrenoceptors, increasing renal blood flow used as an antihypertensive agent.

CAS 19875-60-6 Lisuride maleate

Lisuride maleate
(CAS: 19875-60-6)

Lisuride maleate, an ergot derivative, is a nonselective dopamine receptor agonist with high affinity for D2, D3 and D4 receptors along with 5-HT1A. As an anti-...

CAS 134467-74-6 N-Methyl-N-propyl-2-aminotetraline hydrochloride

N-Methyl-N-propyl-2-aminotetraline hydro
(CAS: 134467-74-6)

N-Methyl-N-propyl-2-Aminotetraline hydrochloride is a dopamine receptor agonist.

Brexpiprazole
(CAS: 913611-97-9)

Brexpiprazole, a novel atypical antipsychotic drug, is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). It is approved for the...

CAS 189744-46-5 RO10-5824

RO10-5824
(CAS: 189744-46-5)

RO10-5824 is a D4-selective partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM), and is approximately 250-fold selectivity over D3 recep...

CAS 269718-83-4 Pardoprunox hydrochloride

Pardoprunox hydrochloride
(CAS: 269718-83-4)

Pardoprunox hydrochloride is the hydrochloride salt form of Pardoprunox. Pardoprunox, also called as SLV308 or DU-126891, is a D2 (pKi = 8.1) and D3 receptor (p...

CAS 138982-67-9 Ziprasidone hydrochloride monohydrate

Ziprasidone hydrochloride monohydrate
(CAS: 138982-67-9)

The hydrochloride monohydrate salt form of Ziprasidone, a benzothiazol derivative, has been found to be a 5HT2A and D2 receptor antagonist that could be used ag...

CAS 76135-29-0 6-Hydroxy-DPAT hydrobromide

6-Hydroxy-DPAT hydrobromide
(CAS: 76135-29-0)

A weak dopamine receptor agonist.

CAS 1021878-34-1 (R)-(+)-7-Hydroxy-DPAT hydrobromide

(R)-(+)-7-Hydroxy-DPAT hydrobromide
(CAS: 1021878-34-1)

A dopamine D3 receptor agonist with more potent activity in comparison with (S)-(-)-7-OH-DPAT.

Haloperidol hydrochloride
(CAS: 1511-16-6)

Haloperidol hydrochloride is a dopamine antagonist that specifically targets D2-like receptors, with effect to treat schizophrenia, acute psychosis, and deliriu...

A 437203
(CAS: 220519-06-2)

A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-f...

Chemical Structure

CAS 57808-66-9 Domperidone

Quick Inquiry

Verification code

Featured Items