Domperidone - CAS 57808-66-9
Catalog number: 57808-66-9
Category: Inhibitor
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Dopamine Receptor
Domperidone is a medication developed by Janssen Pharmaceutica that acts as a peripherally-selective antagonist of the dopamine D2 and D3 receptors.
KW 5338; KW5338; KW-5338; Domperidone; Motilium; Domperidona
Canonical SMILES:
1.Drugs with potential cardiac adverse effects: Retrospective study in a large cohort of parkinsonian patients.
Heranval A1, Lefaucheur R1, Fetter D1, Rouillé A1, Le Goff F1, Maltête D2. Rev Neurol (Paris). 2016 Apr 7. pii: S0035-3787(16)00431-8. doi: 10.1016/j.neurol.2015.11.007. [Epub ahead of print]
INTRODUCTION/OBJECTIVE: Drugs with potential cardiac adverse effects are commonly prescribed in Parkinson's disease (PD). To describe demographic and clinical characteristics in a group of PD patients with cardiac events and to evaluate risk factors.
2.Formulation development and evaluation of medicated chewing gum of anti-emetic drug.
Paradkar M1, Gajra B1, Patel B2. Saudi Pharm J. 2016 Mar;24(2):153-64. doi: 10.1016/j.jsps.2015.02.017. Epub 2015 Apr 3.
CONTEXT: Medicated chewing gum (MCG) of Domperidone Maleate (DM) was developed by direct compression method with the goal to achieve quick onset of action and to improve patient compliance.
3.Characteristics and Functional Roles of Opioids Originally Present in Vivo.
Ozaki M1. Yakugaku Zasshi. 2016;136(4):591-605. doi: 10.1248/yakushi.15-00265.
The characteristics and functional roles of opioids originally present in vivo (endogenous opioids) in guinea-pig ileum were investigated. The release of endogenous opioids was determined by the inhibitory twitch response evoked by 0.1 Hz stimulation after 10 Hz stimulation (post-tetanic twitch inhibition). The effects of peptidase inhibitors increased the post-tetanic twitch inhibition, prevented by β-funaltrexamine and nor-binaltorphimine, which are selective μ- and κ-opioid receptor subtype antagonists, respectively. Dopamine receptor antagonists (haloperidol, sultopride and domperidone) increased the post-tetanic twitch inhibition. These results suggest that dopamine receptors are involved in modulation of the ileal opioid system, so as to diminish endogenous opioid release by tetanic stimulation, and dopamine antagonists increase the opioid action, that might depend more on the increased release of endogenous opioids. The post-tetanic twitch inhibition was inhibited by adrenalectomy, and showed the supersensitivity of the opioid receptors, resulting from a decrease of endogenous opioids by adrenalectomy.
4.Effects of the fish spawning inducer ovaprim on vasotocin receptor gene expression in brain and ovary of the catfish Heteropneustes fossilis with a note on differential transcript expression in ovarian follicles.
Rawat A1, Chaube R1, Joy KP2. Gen Comp Endocrinol. 2016 Mar 7. pii: S0016-6480(16)30046-6. doi: 10.1016/j.ygcen.2016.03.002. [Epub ahead of print]
Ovaprim (OVP), a commercial formulation of a salmon GnRH analogue and the dopamine receptor-2 blocker domperidone, is a successful spawning inducer for fish breeding. It induces a preovulatory surge in LH, which stimulates the synthesis of a maturation-inducing steroid (MIS, 17,20β-dihydroxy-4-pregnen-3-one) that initiates germinal vesicle breakdown (GVBD) and ovulation. Coincidently, the OVP treatment also stimulates vasotocin (VT) secretion in the brain and ovary of the catfish Heteropneustes fossilis that also stimulates the synthesis of the MIS. VT mediates its effect through V1- and V2-type receptors. In the present study in the catfish, we report that OVP stimulates the expression of VT receptor genes v1a1, v1a2 and v2a in the brain and ovary. A single intraperitoneal administration of OVP (0.5μL/g body weight) or incubation of post-vitellogenic ovarian follicles with 5μL/mL OVP, for 0, 4, 8, 12, 16, and 24h stimulated ovulation and GVBD, respectively, in a time-dependent manner.
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CAS 57808-66-9 Domperidone

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