Dolutegravir sodium - CAS 1051375-19-9
Catalog number:
1051375-19-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H18F2N3NaO5
Molecular Weight:
441.36
COA:
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Targets:
HIV
Description:
Dolutegravir sodium salt is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
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Purity:
>98%
Synonyms:
DTG; GSK1349572
MSDS:
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1.Dolutegravir monotherapy in HIV-infected patients with sustained viral suppression.
Rojas J1, Blanco JL1, Marcos MA1, Lonca M1, Tricas A1, Moreno L1, Gonzalez-Cordon A1, Torres B1, Mallolas J1, Garcia F2, Gatell JM1, Martinez E3. J Antimicrob Chemother. 2016 Mar 28. pii: dkw078. [Epub ahead of print]
OBJECTIVES: We reviewed the 24 week outcomes of HIV-infected patients from our hospital who had their ART switched to dolutegravir monotherapy on an individual clinical basis.
2.Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors.
Brenner BG1, Thomas R2, Blanco JL3, Ibanescu RI1, Oliveira M1, Mesplède T1, Golubkov O1, Roger M4, Garcia F5, Martinez E3, Wainberg MA6. J Antimicrob Chemother. 2016 Mar 29. pii: dkw071. [Epub ahead of print]
OBJECTIVES: Dolutegravir shows a high barrier to resistance with no previously reported cases of acquired integrase mutations during first-line therapy. In this study, rapid development of the G118R mutation arose following a switch from first-line elvitegravir/cobicistat/tenofovir disoproxil fumarate/emtricitabine to dolutegravir monotherapy. The G118R mutation also arose in a treatment-experienced patient switched to dolutegravir monotherapy. The genetic basis for G118R selection and potential phenotypic outcome was ascertained.
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CAS 1051375-19-9 Dolutegravir sodium

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