|Targets||ADCs Cytotoxin | Microtubule/Tubulin|
|Description||Dolastatin 10 is an inhibitior of microtubule disassembly (IC50= 1.2μM) and potently inhibits vincristine binding to tubulin in a noncompetitive manner ( Ki= 1.4μM).|
|Brife Description||An inhibitior of microtubule disassembly (IC50= 1.2μM)|
|Appearance||White to off-white solid|
|Synonyms||(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide; Dolastatin 10; UNII-EI946JT51X; CCRIS 7310; EI946JT51X; NSC 376128; L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-,(2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-; isodolastatin 10; 110417-88-4; deo-dolastatin 10; SCHEMBL6423272; C42H68N6O6S; CHEBI:67357; ZINC95803508; CS-1825; HY-15580; LS-161286|
|Solubility||Soluble to 10 mM in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -57℃ for long term (months to years).|
|Boiling Point||903.6ºC at 760 mmHg|
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