Dobutamine HCl - CAS 49745-95-1
Catalog number: 49745-95-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H24ClNO3
Molecular Weight:
337.84
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.
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Purity:
98%
Related CAS:
34368-04-2 (Free base)
Appearance:
Grey solid powder
Synonyms:
4-(2-((4-(4-hydroxyphenyl)butan-2-yl)amino)ethyl)benzene-1,2-diol hydrochloride; LY 81929; LY-81929; LY81929; Dobutamine; Dobutamina; Dobutamina
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years if stored properly
InChIKey:
BQKADKWNRWCIJL-UHFFFAOYSA-N
InChI:
1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
Canonical SMILES:
OC1=CC=C(CCNC(CCC2=CC=C(O)C=C2)C)C=C1O.[H]Cl
1.Combination of single quantitative parameters into multiparametric model for ischemia detection is not superior to visual assessment during dobutamine stress echocardiography.
Čelutkienė J1,2, Burneikaitė G3,4, Petkevičius L5, Balkevičienė L3, Laucevičius A4,6. Cardiovasc Ultrasound. 2016 Apr 12;14(1):13. doi: 10.1186/s12947-016-0055-6.
BACKGROUND: To evaluate if the combination of several quantitative parameters into a mathematical model would enhance the detection of myocardial ischemia during dobutamine stress echocardiography (DSE) when compared to conventional wall motion analysis.
2.Application strategy of PiCCO in septic shock patients.
Liu X1, Ji W1, Wang J1, Pan T1. Exp Ther Med. 2016 Apr;11(4):1335-1339. Epub 2016 Jan 29.
Septic shock, also known as infectious or toxic shock, is a medical condition caused by severe infection and sepsis. Early identification, timely diagnosis and effective treatments are imperative to prevent this medical condition. The aim of the present study was to examine the application of pulse index continuous cardiac output (PiCCO) technique in the treatment of septic shock patients. Fifty septic shock patients were randomly divided into the conventional detection group (group C, n=25) and the PiCCO detection group (group P, n=25). A central venous catheter and radial artery catheter were placed into the patients of group C and a central venous catheter and PiCCO catheter (through femoral artery) were placed in the patients of group P to detect haemodynamics, which was managed and treated according to early goal-directed therapy (EGDT). PiCCO was applied to monitor and guide the application of fluid resuscitation, vasoconstriction drugs (dopamine) and positive inotropic drugs (dobutamine).
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