DL-ThioCtic acid - CAS 1077-28-7
Catalog number:
1077-28-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C8H14O2S2
Molecular Weight:
206.32
COA:
Inquire
Targets:
Others
Description:
DL-α-Lipoic acid is an non-specific free radical scavenger and has anti-oxidant properties. It could be used as a fat-metabolism stimulator.
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Purity:
98%
Appearance:
Light-Yellow Solid
Synonyms:
TIMTEC-BB SBB003484;THIOOCTIC ACID;THIOCTIC ACID;(+-)-2-dithiolane-3-pentanoicacid;(+-)-2-dithiolane-3-valericacid;(+/-)-2-dithiolane-3-pentanoicacid;1,2-Dithiolane-3-pentanoicacid,(+-)-(9CI);2-Dithiolane-3-valericacid,(+-)-1
Solubility:
Ethanol: soluble50 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
DL-α-Lipoic acid is an non-specific free radical scavenger and has anti-oxidant properties. It could be used as a fat-metabolism stimulator.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Density:
1.218g/cm3
InChIKey:
AGBQKNBQESQNJD-UHFFFAOYSA-N
InChI:
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
Canonical SMILES:
C1CSSC1CCCCC(=O)O
1.Protection against acute toxicity of acetaldehyde in mice.
O'Neill PJ, Rahwan RG. Res Commun Chem Pathol Pharmacol. 1976 Jan;13(1):125-8.
The ability of several compounds to protect against acetaldehyde-induced loss of righting reflex was studied in mice and compared with previously published results in rats. L-cysteine (3 mMoles/kg), L-ascorbic acid, DL-thioctic acid, or DL-homocysteine (2 mMoles/kg each) was administered orally 30 minutes prior to an intraperitoneal ED90 of acetaldehyde (415 mg/kg). Cysteine, ascorbate, and thioctic acid caused a statistically significant reduction in acetaldehyde-induced toxicity, while homocysteine afforded only little protection. These results are qualitatively, but not quantitatively, similar to those reported for rats.
2.Controlled co-delivery nanocarriers based on mixed micelles formed from cyclodextrin-conjugated and cross-linked copolymers.
Li S1, He Q1, Chen T1, Wu W1, Lang K1, Li ZM2, Li J3. Colloids Surf B Biointerfaces. 2014 Nov 1;123:486-92. doi: 10.1016/j.colsurfb.2014.09.049. Epub 2014 Sep 30.
The combination of multiple drugs within a single nanocarrier can provide significant advantages for disease therapy and it is desirable to introduce a second drug based on host-guest interaction in these co-delivery systems. In this study, a core-stabilized mixed micellar system consisting of β-cyclodextrin-conjugated poly(lactic acid)-b-poly(ethylene glycol) (β-CD-PLA-mPEG) and DL-Thioctic acid (TA) terminated PLA-mPEG (TA-PLA-mPEG) was developed for the co-delivery of DOX and fluorescein isothiocyanate labeled adamantane (FA). DOX can be loaded within the hydrophobic segment of PLA and FA may form stable complexation with β-CD in the core. The mixed micelles (MM) are based on well-accepted medical materials and can be easily cross-linked by adding 1,4-dithio-D,L-threitol (DTT), which can enhance the stability of the system. Drug-loaded MM system was characterized in terms of particle size, morphology, drug loading and in vitro release profile.
3.Self-assembled monolayers of thiols adsorbed on Au/ZnO-functionalized silica nanosprings: photoelectron spectroscopy-analysis and detection of vaporized explosives.
Kengne BA1, Karmakar S, Kaura M, Sai VV, Corti G, Niraula IB, Larin A, Hall J, Sowell D, Hrdlicka PJ, Dobrokhotov V, McIlroy DN. ACS Appl Mater Interfaces. 2014 Aug 27;6(16):13355-66. doi: 10.1021/am504371k. Epub 2014 Aug 5.
Self-assembled monolayers (SAMs) of thiols of L-cysteine, 6-mercaptohexanol, 4-mercaptobenzoic acid, DL-thioctic acid and 11-(1-pyrenyl)-1-undecathiol, which have been selected for their propensity to interact with vaporized explosives, have been attached from solution onto gold decorated ZnO-coated nanosprings. X-ray and ultraviolet photoelectron spectroscopies (XPS and UPS) have been used to investigate the surface electronic structure of the SAMs coated nanosprings. On the basis of XPS analysis, it has been determined that the packing densities of L-cysteine, 6-mercaptohexanol, 4-mercaptobenzoic acid, DL-thioctic acid and 11-(1-pyrenyl)-1-undecathiol on gold (zinc oxide) are 5.42 × 10(14) (2.83 × 10(14)), 3.26 × 10(14) (2.54 × 10(14)), 9.50 × 10(13), 2.55 × 10(14) (1.12 × 10(14)), and 5.23 × 10(13) molecules/cm(2), respectively. A single S 2p core level doublet is observed for 4-mercaptobenzoic acid and 11-(1-pyrenyl)-1-undecathiol, which is assigned to the S-Au bond.
4.Evidence for facilitated transport of biotin by hamster enterocytes.
Gore J, Hoinard C. J Nutr. 1987 Mar;117(3):527-32.
The uptake of biotin by isolated hamster intestinal cells was investigated in the zone of physiological concentrations. Uptake of the vitamin was not a linear function of the external concentrations and kinetics could be saturated [Km = 1.12 microM, Vmax = 33.9 pmol/(mg protein X min)]. Metabolic inhibitors (antimycin A, 2,4-dinitrophenol) had no effect, so uptake is not energy dependent. Ouabain and N-ethylmaleimide, inhibitors of cation gradients, had no effect on biotin uptake, thus showing the absence of cotransport. The inhibition of uptake by analogs of biotin, that is, biocytin and DL-thioctic acid, indicates that the terminal carboxyl group and the thiophane ring play a role in the recognition of biotin. Counterflow experiments showed competitive inhibition of efflux when excess biotin was present in the cells. These findings are consistent with biotin uptake by isolated hamster enterocytes being a process of facilitated diffusion.
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CAS 1077-28-7 DL-ThioCtic acid

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