|Description||DL-AP3 has been found to be an inhibitor of mGluR as well as HPSP.|
|Purity||≥95% by HPLC|
(S)-MCPG, the active isomer of (RS)-MCPG, is a non-selective group I/group II mGluR antagonist.
JNJ 16259685, a pyrano-quinolin derivative, has been found to be a metabotropic glutamate receptor-1 antagonist.
VU 0360223 is a potent mGlu5 negative allosteric modulator (IC50 = 61 nM) that has no activity at mGlu1-4 and mGlu7-8.
TCN238 is an orally available, brain penetrant and positive allosteric mGlu4 receptor modulator (EC50= 1 μM) with 30-fold selectivity over mGluR5 using human re...
ABP 688 is a high affinity human mGlu5 receptor antagonist (Ki = 1.7 nM) that inhibits the release of glutamate-induced calcium from L(tk-) cells expressing hum...
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. It displays inverse agonist properties. It blocks mGluR5 constitutive activ...
AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety ...
JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.