DL-AP3 - CAS 20263-06-3
Category: Inhibitor
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Molecular Formula:
C3H8NO5P
Molecular Weight:
169.07
COA:
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Targets:
mGluR
Description:
DL-AP3 has been found to be an inhibitor of mGluR as well as HPSP.
Purity:
≥95% by HPLC
Appearance:
White Solid
Synonyms:
DL-2-Amino-3-phosphonopropionic acid
MSDS:
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InChIKey:
LBTABPSJONFLPO-UHFFFAOYSA-N
InChI:
InChI=1S/C3H8NO5P/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)
Canonical SMILES:
C(C(C(=O)O)N)P(=O)(O)O
1.L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices.
Kahle JS1, Cotman CW. J Pharmacol Exp Ther. 1993 Jul;266(1):207-15.
The perforant path is the major excitatory cortical projection to the hippocampal dentate gyrus. Field potentials from the medial perforant path exhibit paired-pulse depression when evoked at interstimulus intervals of 40 to 800 msec. We found that an early component of paired-pulse depression recorded at interstimulus intervals of 40 to 100 msec from slices of rat hippocampus was reduced by L-2-amino-4-phosphonobutanoic acid (L-AP4) (20 microM) without a change in the size of the first field potential in the pair. Paired-pulse depression evoked at intervals of 200 to 800 msec was not reduced. 1S,3R-1-Aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), DL-2-amino-3-phosphonopropionic acid and carbachol also reduced paired-pulse depression in a manner similar to L-AP4. Picrotoxin, phaclofen, theophylline or atropine did not reduce paired-pulse depression. Furthermore, paired-pulse depression (40-100 msec) does not appear to involve glutamate uptake or N-methyl-D-aspartate receptors as L-alpha-aminoadipate did not alter paired-pulse depression and neither trans-L-pyrrolidine-2,4-dicarboxylate and L-alpha-aminoadipate nor D-2-amino-5-phosphonopropionic acid blocked the effect of L-AP4 on paired-pulse depression.
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CAS 20263-06-3 DL-AP3

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