|Product Name||DKM 2-93|
|Description||DKM 2-93 covalently modify the catalytic cysteine of the ubiquitin-like modifier activating enzyme 5 (UBA5), thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins (IC50= 430 μM).|
PYR-41 is a ubiquitin-activating enzyme inhibitor (UBE1 inhibitor). PYR-41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high ...
TZ9, a triazine compound, is a new inhibitor of human E2 enzyme which could selectively bind to the Rad6B catalytic site to restrain the ubiquitination of subst...
DKM 2-93 covalently modify the catalytic cysteine of the ubiquitin-like modifier activating enzyme 5 (UBA5), thereby inhibiting its activity as a protein that a...
PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhi...
CC0651, a Cdc34 ubiquitin-conjugating enzyme allosteric inhibitor, has been found to restrain the cell proliferation at some extent in cancer cell lines PC-3. I...
PYZD-4409 is an inhibitor of ubiquitin-activating enzyme UBA1 (E1). PYZD-4409 induced cell death in malignant cells and preferentially inhibited the clonogenic...
NSC232003, a uracil derivative freely available by the NCI/DTP Repository, is an effective DNA methylation inhibitor.