Divalproex Sodium - CAS 76584-70-8
Catalog number:
B0084-299943
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H31NaO4
Molecular Weight:
310.41
COA:
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Description:
Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor used in the treatment of epilepsy. It acts via binding to and inhibiting gamma-aminobutyric acid (GABA) transaminase.
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B0084-299943 1000 mg $198 In stock
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Brife Description:
HDAC inhibitor, epilepsy
Purity:
>98%
Synonyms:
NSC 694279; EP 475; Valproate semisodium; Depakote; Epival; Depakote ER
MSDS:
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Application:
the treatment of epilepsy
InChIKey:
MSRILKIQRXUYCT-UHFFFAOYSA-M
InChI:
InChI=1S/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1
Canonical SMILES:
CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
1.Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy.
Ilić V1, Bogićević D2, Miljković B1, Ješić M2, Kovačević M3, Prostran M4, Kovačević SV1. Epileptic Disord. 2016 Apr 21. [Epub ahead of print]
To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Serum levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- and age-matched healthy children. Mean valproic acid treatment duration was 2.80±1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p<0.001) and free triiodothyronine (p<0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.
2.In Vivo Chemical Screen in Zebrafish Embryos Identifies Regulators of Hematopoiesis Using a Semiautomated Imaging Assay.
Arulmozhivarman G1, Stöter M2, Bickle M2, Kräter M1, Wobus M1, Ehninger G1, Stölzel F1, Brand M3, Bornhäuser M1, Shayegi N4. J Biomol Screen. 2016 Apr 25. pii: 1087057116644163. [Epub ahead of print]
Hematopoietic stem and progenitor cells (HSPCs) generate all cell types of the blood and are crucial for homeostasis of all blood lineages in vertebrates. Hematopoietic stem cell transplantation (HSCT) is a rapidly evolving technique that offers potential cure for hematologic cancers, such as leukemia or lymphoma. HSCT may be autologous or allogenic. Successful HSCT depends critically on the abundance of engraftment-competent HSPCs, which are currently difficult to obtain in large numbers. Therefore, finding compounds that enhance either the number or the activity of HSPCs could improve prognosis for patients undergoing HSCT and is of great clinical interest. We developed a semiautomated screening method for whole zebrafish larvae using conventional liquid handling equipment and confocal microscopy. Applying this pipeline, we screened 550 compounds in triplicate for proliferation of HSPCs in vivo and identified several modulators of hematopoietic stem cell activity.
3.Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy.
Ilić V1, Bogićević D2, Miljković B1, Ješić M2, Kovačević M3, Prostran M4, Kovačević SV1. Epileptic Disord. 2016 Apr 21. [Epub ahead of print]
To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Serum levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- and age-matched healthy children. Mean valproic acid treatment duration was 2.80±1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p<0.001) and free triiodothyronine (p<0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.
4.Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder.
Yoshimi N1, Futamura T2, Kakumoto K3, Salehi AM4, Sellgren CM5, Holmén-Larsson J6, Jakobsson J6, Pålsson E6, Landén M7, Hashimoto K8. BBA Clin. 2016 Apr 3;5:151-8. doi: 10.1016/j.bbacli.2016.03.008. eCollection 2016.
BACKGROUND: Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis to discover novel peripheral biomarkers for BD.
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CAS 76584-70-8 Divalproex Sodium

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