Dithranol - CAS 1143-38-0
Catalog number: 1143-38-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Dithranol is a hydroxyanthrone, anthracene derivative, medicine applied to the skin of people with psoriasis.
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1.Patient perspectives on treating psoriasis with classic inpatient dithranol therapy: a retrospective patient survey.
Painsi C1,2, Patscheider M2, Inzinger M1,3, Lange-Asschenfeldt B2, Quehenberger F4, Wolf P1. J Dtsch Dermatol Ges. 2015 Nov;13(11):1156-63. doi: 10.1111/ddg.12820.
BACKGROUND: Evidence of the efficacy of dithranol and patient perspectives on the treatment is scant.
2.Dithranol treatment of plaque-type psoriasis increases serum TNF-like weak inducer of apoptosis (TWEAK).
Myśliwiec H1, Myśliwiec P2, Baran A3, Flisiak I3. Adv Med Sci. 2016 Jan 21;61(2):207-211. doi: 10.1016/j.advms.2016.01.001. [Epub ahead of print]
PURPOSE: TNF-like weak inducer of apoptosis (TWEAK) mediates not only apoptosis, but also inflammation, cell growth and angiogenesis. The role of TWEAK in psoriasis remains unknown. The aim of the study was to assess serum levels of TWEAK in psoriatic patients before and after topical treatment with dithranol in relation to the clinical activity of the disease.
3.Synthesis and biological evaluation of new C-10 substituted dithranol pleiotropic hybrids.
Bariamis SE1, Magoulas GE1, Grafanaki K2, Pontiki E3, Tsegenidis T1, Athanassopoulos CM1, Maroulis G1, Papaioannou D4, Hadjipavlou-Litina D5. Bioorg Med Chem. 2015 Nov 15;23(22):7251-63. doi: 10.1016/j.bmc.2015.10.022. Epub 2015 Oct 23.
Selective alkylation of the antipsoriatic drug dithranol (DTR) at C-10 with tert-butyl bromoacetate, followed by acid-mediated deprotection, produced the corresponding carboxylic acid 4 which was coupled with selectively protected polyamines (PAs), such as putrescine (PUT), spermidine (SPD) and spermine (SPM), dopamine and aliphatic amines and substituted benzylamines producing a series of DTR-PA hybrids, after acid-mediated deprotection, as well as simple amides. The compounds were tested as antioxidants and inhibitors of lipoxygenase (LOX). The amides 4,4'-dimethoxybenzhydrylamide 13 (86% and 95%), 2,4-dimethoxybenzylamide 12 (87% and 81%) and dodecylamide 9 (98% and 74%), and the hybrid DTR-SPM (7) (93% and 87%), showed the highest antioxidant activity in the DPPH and AAPH assays, whereas the most potent inhibitors of LOX were amide 13 (IC50=7 μM), the benzylamide 10 (IC50=7.9 μM) and the butylamide 8 (IC50=10 μM). Molecular binding studies showed that binding of these derivatives into the hydrophobic domain blocks approach of substrate to the active site, inhibiting soybean LOX.
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CAS 1143-38-0 Dithranol

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