Dithioerythritol - CAS 6892-68-8
Catalog number:
6892-68-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C4H10O2S2
Molecular Weight:
154.25
COA:
Inquire
Targets:
Others
Description:
Dithioerythritol, a sulfur containing sugar derived from the corresponding 4-carbon monosaccharide erythrose, is an epimer of dithiothreitol(DTT).
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Purity:
≥98%
Appearance:
White solid
Synonyms:
1,4-Dithioerythritol; (2R,3S)-1,4-bis(sulfanyl)butane-2,3-diol;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
White crystals
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
364.5°C at 760 mmHg
Melting Point:
83-86 °C
Density:
1.302 g/cm3
InChIKey:
VHJLVAABSRFDPM-ZXZARUISSA-N
InChI:
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
Canonical SMILES:
C(C(C(CS)O)O)S
1.The fructanolytic abilities of the rumen bacterium Butyrivibrio fibrisolvens strain 3071.
Kasperowicz A1, Stan-Głasek K1, Taciak M1, Michałowski T1. J Appl Microbiol. 2016 Jan;120(1):29-40. doi: 10.1111/jam.12976. Epub 2015 Dec 8.
AIMS: To determine if Butyrivibrio fibrisolvens strain 3071 is able to use fructose polymers for growth and to identify the enzymes involved in their digestion.
2.Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition.
Galluccio M1, Pochini L1, Peta V1, Iannì M1, Scalise M1, Indiveri C2. Toxicol Sci. 2015 Mar;144(1):105-13. doi: 10.1093/toxsci/kfu259. Epub 2014 Dec 8.
The effect of mercury compounds has been tested on the organic cation transporter, hOCTN1. MeHg(+), Hg(2+), or Cd(2+) caused strong inhibition of transport. 1,4-Dithioerythritol (DTE), cysteine (Cys), and N-acetyl-l-cysteine reversed (NAC) the inhibition at different extents. 2-Aminoethyl methanethiosulfonate hydrobromide (MTSEA), a prototype SH reagent, exerted inhibition of transport similar to that observed for the mercurial agents. To investigate the mechanism of action of mercurials, mutants of hOCTN1 in which each of the Cys residues was substituted by Ala have been constructed, over-expressed in Escherichia coli, and purified. Tetraethylammonium chloride (TEA) uptake mediated by each mutant in proteoliposomes was comparable to that of wild type (WT). IC50 values of the WT and mutants for the mercury compounds were derived from dose-response analyses. The mutants C50A and C136A showed significant increase of IC50 indicating that the 2 Cys residues were involved in the interaction with the mercury compounds and inhibition of the transporter.
3.Tauroursodeoxycholic acid prevents stress induced aggregation of proteins in vitro and promotes PERK activation in HepG2 cells.
Gani AR1, Uppala JK1, Ramaiah KV2. Arch Biochem Biophys. 2015 Feb 15;568:8-15. doi: 10.1016/j.abb.2014.12.031. Epub 2015 Jan 8.
Tauroursodeoxycholic acid (TUDCA) a bile salt and chemical chaperone reduces stress-induced aggregation of proteins; activates PERK [PKR (RNA-dependent protein kinase)-like ER (endoplasmic reticulum) kinase] or EIF2AK3, one of the hall marks of ER stress induced unfolded protein response (UPR) in human hepatoblastoma HepG2 cells; prevents heat and dithiothreitol (DTT) induced aggregation of BSA (bovine serum albumin), and reduces ANS (1-anilino-naphthalene-8-sulfonate) bound BSA fluorescence in vitro. TUDCA inactivates heat treated, but not the native EcoR1 enzyme, and reduces heat-induced aggregation and activity of COX-1 (cyclooxygenase enzyme-1) in vitro. These findings suggest that TUDCA binds to the hydrophobic regions of proteins and prevents their subsequent aggregation. This may stabilize unfolded proteins that can mount UPR or facilitate their degradation through cellular degradation pathways.
4.In vivo heat inactivation of serum can distinguish false positive cross matches in renal transplants.
Riley AA1, Klingman L2,3, Brier ME4, Chand DH5,6. Int J Artif Organs. 2016 Mar 21;39(2):63-7. doi: 10.5301/ijao.5000470. Epub 2016 Feb 29.
INTRODUCTION: Renal transplants have traditionally been performed despite positive cross match if results are presumptively due to IgM antibodies. False positives have been distinguishable from true positives by dithiothreitol or dithioerythritol treatment to inactivate IgM antibodies. Heat inactivation, which renders the antibodies inactive, is an alternative to chemical amelioration.
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Chemical Structure

CAS 6892-68-8 Dithioerythritol

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