Dipyridamole - CAS 58-32-2
Catalog number:
58-32-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H40N8O4
Molecular Weight:
504.63
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
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Purity:
>98%
Synonyms:
NSC-515776
MSDS:
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1.The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism.
Karaguzel E1, Bayraktar C1, Kutlu O1, Yulug E2, Mentese A3, Okatan AE1, Colak F1, Ozer S3, Kazaz IO1. Int Braz J Urol. 2016 Jan-Feb;42(1):146-53. doi: 10.1590/S1677-5538.IBJU.2015.0072.
PURPOSE: To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats.
2.An investigation into the crystallization tendency/kinetics of amorphous active pharmaceutical ingredients: A case study with dipyridamole and cinnarizine.
Baghel S1, Cathcart H1, Redington W2, O'Reilly NJ3. Eur J Pharm Biopharm. 2016 Apr 21. pii: S0939-6411(16)30141-2. doi: 10.1016/j.ejpb.2016.04.017. [Epub ahead of print]
Amorphous drug formulations have great potential to enhance solubility and thus bioavailability of BCS class II drugs. However, the higher free energy and molecular mobility of the amorphous form drives them towards the crystalline state which makes them unstable. Accurate determination of the crystallization tendency/kinetics is the key to the successful design and development of such systems. In this study, dipyridamole (DPM) and cinnarizine (CNZ) has been selected as model compounds. Thermodynamic fragility (mT) was measured from the heat capacity change at the glass transition temperature (Tg) whereas dynamic fragility (mD) was evaluated using methods based on extrapolation of configurational entropy to zero [Formula: see text] , and heating rate dependence of Tg [Formula: see text] . The mean relaxation time of amorphous drugs was calculated from the Vogel-Tammann-Fulcher (VTF) equation. Furthermore, the correlation between fragility and glass forming ability (GFA) of the model drugs has been established and the relevance of these parameters to crystallization of amorphous drugs is also assessed.
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CAS 58-32-2 Dipyridamole

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