Dipraglurant - CAS 872363-17-2
Catalog number: 872363-17-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease.
Publictions citing BOC Sciences Products
  • >> More
ADX 48621
1.The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Bezard E1, Pioli EY, Li Q, Girard F, Mutel V, Keywood C, Tison F, Rascol O, Poli SM. Mov Disord. 2014 Jul;29(8):1074-9. doi: 10.1002/mds.25920. Epub 2014 May 27.
BACKGROUND: Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson's disease (PD). We assessed the effect on LID of dipraglurant, a potent selective mGluR5 receptor negative allosteric modulator in the gold-standard LID macaque model.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mGluR Products

CAS 162870-29-3 (S)-3,5-DHPG

(CAS: 162870-29-3)

(S)-3,5-DHPG is a selective group I mGluR agonist used for the treatment of neuronal injury and cognitive enhancement.

CAS 198419-91-9 LY 367385

LY 367385
(CAS: 198419-91-9)

LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is u...

CAS 1161205-04-4 VU 0361737

VU 0361737
(CAS: 1161205-04-4)

CAS 20263-06-3 DL-AP3

(CAS: 20263-06-3)

DL-AP3 has been found to be an inhibitor of mGluR as well as HPSP.

CAS 150145-89-4 (S)-MCPG

(CAS: 150145-89-4)

(S)-MCPG, the active isomer of (RS)-MCPG, is a non-selective group I/group II mGluR antagonist.

CAS 299900-84-8 YM 202074

YM 202074
(CAS: 299900-84-8)

YM 202074 is a high affinity and selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM 202074 binds to an allosteric site of the rat mGlu1 rec...

CAS 1246086-78-1 VU 0364439

VU 0364439
(CAS: 1246086-78-1)

CAS 334887-48-8 (S)-HexylHIBO

(CAS: 334887-48-8)

(S)-HexylHIBO is a Group I mGlu receptor antagonist (Kb = 30 and 61 μM at mGlu1a and mGlu5a receptors, respectively).

CAS 71301-82-1 (S)-3-Hydroxyphenylglycine

(CAS: 71301-82-1)

(S)-3-Hydroxyphenylglycine is an agonist at group I metabotropic glutamate receptors (mGlu1) with no effect at mGlu2 or mGlu4.

CAS 524924-76-3 Methoxy-PEPy

(CAS: 524924-76-3)

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist.

CAS 852679-66-4 (±)-LY 395756

(±)-LY 395756
(CAS: 852679-66-4)

(±)-LY 395756 is a mixed mGlu2 agonist/mGlu3 antagonist.

CAS 125404-04-8 TCN238

(CAS: 125404-04-8)

TCN238 is an orally available, brain penetrant and positive allosteric mGlu4 receptor modulator (EC50= 1 μM) with 30-fold selectivity over mGluR5 using human re...

CAS 19641-83-9 (RS)-3,5-DHPG

(CAS: 19641-83-9)

(RS)-3,5-DHPG is a group I metabotropic glutamate receptor (mGluR) agonist with selectivity for both mGlu1 and mGlu5. It is also acts as an antagonist at metabo...

CAS 103439-17-4 Z-Cyclopentyl-AP4

(CAS: 103439-17-4)

Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist with higher potency at mGlu4 than mGlu8 (EC50 = 49 and 124 μM, respectively). Z-Cyclopentyl-AP4 selective...

CAS 232605-26-4 Bay 36-7620

Bay 36-7620
(CAS: 232605-26-4)

BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity.

(CAS: 932737-65-0)

FITM is a potent mGlu1 inhibitor (Ki = 2.5 nM) with great selectivity that does not disrupt mGlu5.

CAS 353229-59-1 LY 487379 hydrochloride

LY 487379 hydrochloride
(CAS: 353229-59-1)

LY-487379 is an allosteric modulator for the metabotropic glutamate receptor group II subtype. It has anti-hyperthermic effects.

CAS 170846-74-9 CHPG

(CAS: 170846-74-9)

CHPG is a selective metabotropic glutamate 5 (mGlu5) receptor agonist, and it is inactive in CHO cells. CHPG potentiates NMDA-induced depolarizations in rat hip...

CAS 195209-04-2 ACPT-II

(CAS: 195209-04-2)

ACPT-II has been found to be a mGluR antagonist and could probably exhibit neuroprotective effects.

CAS 1093757-42-6 VU 0155041

VU 0155041
(CAS: 1093757-42-6)

VU 0155041 is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displ...

Chemical Structure

CAS 872363-17-2 Dipraglurant

Quick Inquiry

Verification code

Featured Items