|Description||Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease.|
(S)-3,5-DHPG is a selective group I mGluR agonist used for the treatment of neuronal injury and cognitive enhancement.
LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is u...
DL-AP3 has been found to be an inhibitor of mGluR as well as HPSP.
(S)-MCPG, the active isomer of (RS)-MCPG, is a non-selective group I/group II mGluR antagonist.
YM 202074 is a high affinity and selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM 202074 binds to an allosteric site of the rat mGlu1 rec...
(S)-HexylHIBO is a Group I mGlu receptor antagonist (Kb = 30 and 61 μM at mGlu1a and mGlu5a receptors, respectively).
(S)-3-Hydroxyphenylglycine is an agonist at group I metabotropic glutamate receptors (mGlu1) with no effect at mGlu2 or mGlu4.
Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist.
(±)-LY 395756 is a mixed mGlu2 agonist/mGlu3 antagonist.
TCN238 is an orally available, brain penetrant and positive allosteric mGlu4 receptor modulator (EC50= 1 μM) with 30-fold selectivity over mGluR5 using human re...
(RS)-3,5-DHPG is a group I metabotropic glutamate receptor (mGluR) agonist with selectivity for both mGlu1 and mGlu5. It is also acts as an antagonist at metabo...
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist with higher potency at mGlu4 than mGlu8 (EC50 = 49 and 124 μM, respectively). Z-Cyclopentyl-AP4 selective...
BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity.
FITM is a potent mGlu1 inhibitor (Ki = 2.5 nM) with great selectivity that does not disrupt mGlu5.
LY 487379 hydrochloride
LY-487379 is an allosteric modulator for the metabotropic glutamate receptor group II subtype. It has anti-hyperthermic effects.
CHPG is a selective metabotropic glutamate 5 (mGlu5) receptor agonist, and it is inactive in CHO cells. CHPG potentiates NMDA-induced depolarizations in rat hip...
ACPT-II has been found to be a mGluR antagonist and could probably exhibit neuroprotective effects.
VU 0155041 is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displ...