Dipraglurant - CAS 872363-17-2
Catalog number:
872363-17-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H12FN3
Molecular Weight:
265.29
COA:
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Targets:
mGluR
Description:
Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease.
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Purity:
>98%
Synonyms:
ADX 48621
MSDS:
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1.The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Bezard E1, Pioli EY, Li Q, Girard F, Mutel V, Keywood C, Tison F, Rascol O, Poli SM. Mov Disord. 2014 Jul;29(8):1074-9. doi: 10.1002/mds.25920. Epub 2014 May 27.
BACKGROUND: Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson's disease (PD). We assessed the effect on LID of dipraglurant, a potent selective mGluR5 receptor negative allosteric modulator in the gold-standard LID macaque model.
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