|Description||Diphenylpyraline, a piperidine derivative, has been found to be a H1 receptor antagonist that could be probably effective against some allergy acts.|
|Synonyms||Diphenylpyraline; Hispril; Belfene; Mepiben; Allergen; Lyssipoll; 4-benzhydryloxy-1-methylpiperidine|
|Storage||Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).|
|Quality Standard||In-house standard|
Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.
A 987306 is a potent histamine H4 receptor antagonist (pKi = 8.24 and 8.47 in human and rat H4 receptors, respectively) with 162-, 620-, and > 1600-fold selecti...
Irdabisant is a potent, selective histamine H3 receptor inverse agonist. It displayed potent antagonist and inverse agonist activities in [³⁵S]guanosine 5'-O-(γ...
Famotine hydrochloride is a histamine H2 receptor antagonist. lt has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other ...
Histamine is an organic nitrogenous compound produced by basophils and by mast cells found in nearby connective tissues.
Bepotastine is a histamine H1 receptor antagonist. Bepotastine has been approved in Japan for the treatment of allergic rhinitis and uriticaria/puritus.
Levoprotiline is a Histamine H1 receptor antagonist originated by Novartis. It is an antidepressant. But clinical trials for Major depressive disorder were disc...
Chlorcyclizine is a first-generation Histamine Receptor antagonist of the phenylpiperazine class. It can be used primarily to treat allergy symptoms such as rhi...
Diphenhydramine is a histamine H1 antagonist. t competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous hist...
Tiprolisant is potent and selective nonimidazole inverse agonist at the histamine H3 receptor. (Ki=0.16 nM).
Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patient...
Dexbrompheniramine is an histamine H1-receptor antagonist used for the treatment of allergic conditions including hay fever or urticaria. It is the pharmacologi...
Mianserin is a tetracyclic second generation antidepressant. It has the same efficacy as the tricyclics, but has no anticholinergic and cardiovascular side-effe...
A 331440 dihydrochloride
A 331440 dihydrochloride is a histamine H3 receptor antagonist (Ki = 21.7 and 22.7 nM for rat and human H3 receptors, respectively). A 331440 reduces weight in ...
Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor.
Emedastine is a H1 receptor antagonist. It is a second generation antihistamine. Emedastine can block the action of histamine that causes allergic symptoms. It ...
Immepip dihydrobromide is the dihydrobromide salt of immepip, which is a potent and selective nonchiral histamine H3 receptor agonist with Ki values of 0.4 nM. ...
Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
JNJ 5207852 dihydrochloride
The hydrochloride salt form of JNJ 5207852, which has been found to be a histamine H3 receptor antagonist and could probably be used against obesity.