Diphenylpyraline - CAS 147-20-6
Catalog number:
147-20-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H23NO
Molecular Weight:
281.39
COA:
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Targets:
Histamine Receptor
Description:
Diphenylpyraline, a piperidine derivative, has been found to be a H1 receptor antagonist that could be probably effective against some allergy acts.
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Purity:
98%
Appearance:
Powder
Synonyms:
Diphenylpyraline; Hispril; Belfene; Mepiben; Allergen; Lyssipoll; 4-benzhydryloxy-1-methylpiperidine
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
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Quality Standard:
In-house standard
Quantity:
Milligram-Grams
Density:
1.08 g/cm3
InChIKey:
OWQUZNMMYNAXSL-UHFFFAOYSA-N
InChI:
InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
Canonical SMILES:
CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3
1.Application of dummy molecularly imprinted solid-phase extraction in the analysis of cyproheptadine in bovine urine.
Feás X1, Ye L, Regal P, Fente CA, Hosseini SV, Cepeda A. J Sep Sci. 2009 May;32(10):1740-7. doi: 10.1002/jssc.200800726.
Due to the difficulty of monitoring trace levels of cyproheptadine (CYP) residues in complicated biological matrices, specific adsorption materials for the preconcentration and clean-up of CYP are indispensable. In this work, CYP was extracted from urine using dummy molecularly imprinted SPE (DMISPE) to avoid leakage of the imprinting molecules during the desorption phase. For synthesis of DMISPE, azatadine (AZA) was employed as the dummy template, methacrylic acid (MAA) as the monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, 2,2'-azobis(2-methylpropionitrile) (AIBN) as the initiator, and dichloromethane as the porogen solvent. An LC-MS/MS method was used to analyze CYP. Two MRM (multiple reaction monitoring) transitions for each analyte were monitored using diphenylpyraline hydrochloride (DPP.HCl), which was used as an internal standard. The advantages of DMISPE include obtaining less complex chromatograms and reducing ion suppression in ESI.
2.Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward.
Oleson EB1, Ferris MJ, España RA, Harp J, Jones SR. Eur J Pharmacol. 2012 May 15;683(1-3):161-5. doi: 10.1016/j.ejphar.2012.03.003. Epub 2012 Mar 15.
Diphenylpyraline hydrochloride (DPP) is an internationally available antihistamine that produces therapeutic antiallergic effects by binding to histamine H₁ receptors. The complete neuropharmacological and behavioral profile of DPP, however, remains uncharacterized. Here we describe studies that suggest DPP may fit the profile of a potential agonist replacement medication for cocaine addiction. Aside from producing the desired histamine reducing effects, many antihistamines can also elicit psychomotor activation and reward, both of which are associated with increased dopamine concentrations in the nucleus accumbens (NAc). The primary aim of this study was to investigate the potential ability of DPP to inhibit the dopamine transporter, thereby leading to elevated dopamine concentrations in the NAc in a manner similar to cocaine and other psychostimulants. The psychomotor activating and rewarding effects of DPP were also investigated. For comparative purposes cocaine, a known dopamine transporter inhibitor, psychostimulant and drug of abuse, was used as a positive control.
3.Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010).
Wentworth AB1, Yiannias JA2, Keeling JH3, Hall MR3, Camilleri MJ4, Drage LA5, Torgerson RR5, Fett DD6, Prakash AV7, Scalf LA8, Allen EM5, Johnson JS2, Singh N2, Nordberg Linehan DL3, Killian JM9, Davis MD10. J Am Acad Dermatol. 2014 Feb;70(2):269-75.e4. doi: 10.1016/j.jaad.2013.09.047. Epub 2013 Nov 20.
BACKGROUND: Patch testing is essential for identification of culprits causing allergic contact dermatitis.
4.[Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age].
Montijo-Barrios E1, Cadena F, Ramírez-Mayans JA, Gutiérrez-Castrellón P. Rev Invest Clin. 2011 Jul-Aug;63(4):335-43.
INTRODUCTION: Acute respiratory infections are the second leading cause of morbidity in children under 18 years. Several drugs have been used with variable efficacy and safety, trying to reduce the associated symptoms and improve quality of life.
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CAS 147-20-6 Diphenylpyraline

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