|Description||Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.|
Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist (pKi = 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors, respectively). Zamifenac...
Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
VU 6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) (IC50 values of 1.2 and 1.6 μM in human and rat M5...
VU 0365114 is a selective positive allosteric modulator of M5 muscarinic acetylcholine receptor (mAChR) (EC50 = 2.7 μM for human M5, and >30 μM for M1, M2, M3 a...
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially coup...
Vinconate, a vinca alkaloid derivative, can stimulate the muscariic acetylcholine receptor. Vinconate prevents ischemic neuronal damage by direct action on the ...
VU 10010 is a selective allosteric potentiator at M4 acetylcholine receptors (EC50 = 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively)....
Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure an...
The maleate salt form of (S)-(+)-Dimethindene, which has been found to be a subtype-selective mAChR M2 antagonist and histamine H1 receptor antagonist.
4-DAMP is a potent and selective antagonist of the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors. Blockade of mAChR M2 leads to a ...
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).
Tarafenacin is a highly selective M3 muscarinic receptor antagonist. It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-ch...
Arecaidine But-2-ynyl Ester Tosylate (ABET) is a potent and selective agonist of M2 recceptors in the atrium versus those in the ileum.
CDD0102 is a selective M1 agonist which stimulated the secretion of APP from CHO-K1 cells expressing M1 receptors and penetrated into the brain following i.p. a...
Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
[D-Trp 7,9,10]-Substance P
[D-Trp 7,9,10]-Substance P is a substance P analog that blocks activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh re...
Pirmenol, also known as CI-845, a new antiarrhythmic drug, inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. However, pirm...
AC260584 is a potent and selective muscarinic M₁ receptor allosteric agonist (pEC50= 7.6). Studies indicated that AC260584 has a behavioral profile consistent w...
Tiotropium Bromide, an azoniatricyclo derivative, is a mAChR antagonist that could be used as bronchodilation agent and smooth muscle relaxant.
Arecoline is a muscarinic acetylcholine receptor agonist.