Diphenhydramine HCl - CAS 147-24-0
Catalog number: 147-24-0
Category: Inhibitor
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Histamine Receptor
Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations.
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1. Evaluation of the relationship between cetuximab therapy and corrected QT interval changes in patients with advanced malignancies from solid tumors
J. F. Deeken • B. Shimkus • A. Liem • D. Hill • J. Gurtler • E. Berghorn • L. Townes • H. Lu • O. Trifan • S. Zhang. Cancer Chemother Pharmacol (2013) 71:1473–1483
Cetuximab was administered as intravenous infusions at an initial dose of 400 mg/m2 administered over 120 min on day 1 (week 1) followed by a maintenance dose of 250 mg/m2 administered over 60 min weekly thereafter. The administration of the recommended premedication (diphenhydramine HCl 50 mg) was required for the first 5 doses of cetuximab. Diphenhydramine HCl 50 mg was also required to be administered during the baseline monitoring to account for any change in QT interval related to its administration.ECG monitoring was performed at screening, baseline (week 1 preceding dosing), and during week 1 to 5 of treatment. Serum concentration samples were obtained at time-matched points during the administration in week 1 to 5. Following the completion of the ECG monitoring in week 5, the addition of other therapy (e.g., chemotherapy and/or radiation therapy) was allowed as per investigator discretion. Patients who were stable or responding to cetuximab at week 9 were eligible to continue treatment off-study with cetuximab and/or other therapy.
2. Deliquescence in Binary Mixtures
Adnan K. Salameh and Lynne S. Taylor. Pharmaceutical Research, Vol. 22, No. 2, February 2005
In Fig. 3, sorption isotherms are shown for ranitidine HCl, sucrose, and three physical mixtures of ranitidine HCl and sucrose consisting of 10:90, 50:50, and 90:10 w/w blends. The physical mixtures appear to undergo deliquescence at a lower relative humidity than either of the individual components (i.e., at a unique RH that can be designated RH0mix). Furthermore, the composition of the physical mixture does not appear to influence RH0mix within experimental limitations. The same phenomenon was observed for mixtures of diphenhydramine HCl and sucrose. In this case, the individual components have similar RH0 values of 82% and 85% for diphenhydramine HCl and sucrose, respectively, whereas RH0mix was around 76% (Table II). In contrast, anhydrous lactose was found to have minimal effect on the deliquescence behavior of ranitidine HCl, and mixtures of these two components were found to deliquesce close to RH0 of ranitidine HCl, as shown in Fig. 4. For ranitidine HCl, in addition to investigating the effect of sucrose and lactose, a series of inorganic salts were also examined. For all of the salts, RH0mix was lower than RH0 of the individual components, and results are summarized in Table II.
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CAS 147-24-0 Diphenhydramine HCl

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