Dioxybenzone - CAS 131-53-3
Catalog number:
131-53-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H12O4
Molecular Weight:
244.25
COA:
Inquire
Targets:
Others
Description:
Dioxybenzone, a phenol derivative, could be widely used to block UVB and UVA in sunscreen products.
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Purity:
95%
Appearance:
Off white to yellow free flowing powder
Synonyms:
dioxybenzone;2,2'-DIHYDROXY-4-METHOXYBENZOPHENONE;131-53-3;Dioxybenzon;Advastab47;CyasorbUV24
Solubility:
10 mM in DMSO
Storage:
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
MSDS:
Inquire
Application:
Dioxybenzone could be widely used to block UVB and UVA in sunscreen products.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
170-175ºC
Melting Point:
73-75ºC
Density:
1.296 g/cm3
InChIKey:
MEZZCSHVIGVWFI-UHFFFAOYSA-N
InChI:
InChI=1S/C14H12O4/c1-18-9-6-7-11(13(16)8-9)14(17)10-4-2-3-5-12(10)15/h2-8,15-16H,1H3
Canonical SMILES:
COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2O)O
1.Determination of benzophenone-3 and its main metabolites in human serum by dispersive liquid-liquid microextraction followed by liquid chromatography tandem mass spectrometry.
Tarazona I1, Chisvert A, Salvador A. Talanta. 2013 Nov 15;116:388-95. doi: 10.1016/j.talanta.2013.05.075. Epub 2013 Jun 6.
A new analytical method for the determination of benzophenone-3 (2-hydroxy-4-methoxybenzophenone), and its main metabolites (2,4-dihydroxybenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone) in human serum is presented. The method is based on dispersive liquid-liquid microextraction (DLLME) as preconcentration and clean-up technique, followed by liquid chromatography tandem mass spectrometry (LC-MS/MS). Acidic hydrolysis and protein precipitation with HCl 6 M (1:1) (100 °C, 1 h) were carried out before extraction. The variables involved in the DLLME process were studied. Under the optimized conditions, 70 µL of acetone (disperser solvent) and 30 µL of chloroform (extraction solvent) were mixed and rapidly injected into 800 µL of hydrolyzed serum sample. Sample pH or ionic strength adjustment were not necessary. The method was validated by analyzing spiked human serum samples. No satisfactory recoveries were obtained when aqueous standards or standards prepared in synthetic serum were used, but excellent recoveries were achieved by using matrix-matched calibration standards.
2.Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality.
Louis GM1, Chen Z2, Kim S2, Sapra KJ3, Bae J4, Kannan K5. Fertil Steril. 2015 Oct;104(4):989-96. doi: 10.1016/j.fertnstert.2015.07.1129. Epub 2015 Aug 5.
OBJECTIVE: To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints.
3.A novel two-dimensional liquid-chromatography method for online prediction of the toxicity of transformation products of benzophenones after water chlorination.
Li J1, Ma LY, Xu L, Shi ZG. Anal Bioanal Chem. 2015 Aug;407(20):6137-48. doi: 10.1007/s00216-015-8789-9. Epub 2015 Jun 6.
Benzophenone-type UV filters (BPs) are ubiquitous in the environment. Transformation products (TPs) of BPs with suspected toxicity are likely to be produced during disinfection of water by chlorination. To quickly predict the toxicity of TPs, in this study, a novel two-dimensional liquid-chromatography (2D-LC) method was established in which the objective of the first dimension was to separate the multiple components of the BPs sample after chlorination, using a reversed-phase liquid-chromatography mode. A biochromatographic system, i.e. bio-partitioning micellar chromatography with the polyoxyethylene (23) lauryl ether aqueous solution as the mobile phase, served as the second dimension to predict the toxicity of the fraction from the first dimension on the basis of the quantitative retention-activity relationships (QRARs) model. Six BPs, namely 2,4-dihydroxybenzophenone, oxybenzone, 4-hydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone, were the target analytes subjected to chlorination.
4.Couples' urinary concentrations of benzophenone-type ultraviolet filters and the secondary sex ratio.
Bae J1, Kim S2, Kannan K3, Buck Louis GM4. Sci Total Environ. 2016 Feb 1;543(Pt A):28-36. doi: 10.1016/j.scitotenv.2015.11.019. Epub 2015 Nov 12.
The secondary sex ratio (SSR), defined as the ratio of males to females at birth, has been investigated in relation to endocrine disruptors to search for environmental toxicants perturbing human sex selection. Benzophenone (BP)-type ultraviolet (UV) filters, which are used in sunscreens and personal care products, have been reported to exert estrogenic and anti-androgenic activities. This study aimed to evaluate the association between maternal, paternal, and couple urinary concentrations of BP-type UV filters and the SSR, given the absence of previous investigation. The study cohort comprised 220 couples who were enrolled in the Longitudinal Investigation of Fertility and the Environment (LIFE) Study between 2005 and 2009 prior to conception and who had a singleton birth during the follow-up period. Couples' urinary concentrations of five BP-type UV filters (ng/mL) were measured using triple-quadrupole tandem mass spectrometry: 2,4-dihydroxybenzophenone (BP-1), 2,2',4,4'-tetrahydroxybenzophenone (BP-2), 2-hydroxy-4-methoxybenzophenone (BP-3), 2,2'-dihydroxy-4-methoxybenzophenone (BP-8), and 4-hydroxybenzophenone (4-OH-BP).
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CAS 131-53-3 Dioxybenzone

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