Diosgenin - CAS 512-04-9
Catalog number:
512-04-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H42O3
Molecular Weight:
414.62
COA:
Inquire
Targets:
Others
Description:
Diosgenin, a steroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone), diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.
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Purity:
>98%
MSDS:
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1.Mitochondrial dysfunction in H9c2 cells during ischemia and amelioration with Tribulus terrestris L.
Reshma PL1, Sainu NS1, Mathew AK2, Raghu KG3. Life Sci. 2016 Apr 2. pii: S0024-3205(16)30201-6. doi: 10.1016/j.lfs.2016.03.055. [Epub ahead of print]
AIMS: The present study investigates the protective effect of partially characterized Tribulus terrestris L. fruit methanol extract against mitochondrial dysfunction in cell based (H9c2) myocardial ischemia model.
2.Steroidal Saponin Diosgenin from Dioscorea bulbifera Protects Cardiac Cells from Hypoxia-reoxygenation Injury Through Modulation of Pro-survival and Pro-death Molecules.
Jayachandran KS1, Vasanthi AH2, Gurusamy N3. Pharmacogn Mag. 2016 Jan;12(Suppl 1):S14-20. doi: 10.4103/0973-1296.176114.
BACKGROUND: Diosgenin, a steroidal saponin from plants, exhibits many biological potentials. Herein, the cardioprotective role of diosgenin is studied.
3.Steroidal Saponin Diosgenin from Dioscorea bulbifera Protects Cardiac Cells from Hypoxia-reoxygenation Injury Through Modulation of Pro-survival and Pro-death Molecules.
Jayachandran KS1, Vasanthi AH2, Gurusamy N3. Pharmacogn Mag. 2016 Jan;12(Suppl 1):S14-20. doi: 10.4103/0973-1296.176114.
BACKGROUND: Diosgenin, a steroidal saponin from plants, exhibits many biological potentials. Herein, the cardioprotective role of diosgenin is studied.
4.Diosgenin effectively suppresses skin inflammation induced by phthalic anhydride in IL-4/Luc/CNS-1 transgenic mice.
Kim JE1, Go J1, Koh EK1, Song SH1, Sung JE1, Lee HA1, Kim DS1, Son HJ1, Lee HS2, Lee CY3, Hong JT4, Hwang DY1. Biosci Biotechnol Biochem. 2016 May;80(5):891-901. doi: 10.1080/09168451.2015.1135040. Epub 2016 Mar 21.
To quantitatively evaluate the therapeutic effects of diosgenin (DG) and investigate the role of IL-4 on skin inflammation, alterations in luciferase-derived signal and general phenotype biomarkers were measured in IL-4/Luc/CNS-1 transgenic mice with phthalic anhydride (PA)-induced skin inflammation after treatment with DG for 4 weeks. High levels of luciferase-derived signal detected in the abdominal region and submandibular lymph node (SL) of the PA treated group was significantly decreased by 67-88% in the PA + DG cotreated group. Furthermore, the weight of the lymph node and spleen, IgE concentration, epidermis thickness, and number of infiltrated mast cells were lower in the PA + DG treated group than the PA + Vehicle treated group. Moreover, expression of IL-6 and vascular endothelial growth factor (VEGF) also decreased in the PA + DG cotreated group. These results suggest that PA-induced skin inflammation could be successfully suppressed by DG treatment in IL-4/Luc/CNS-1 Tg mice through attenuation of IL-4 and IL-6 expression, as well as decreased IgE concentration and mast cells infiltration.
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CAS 512-04-9 Diosgenin

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