Dioscin - CAS 19057-60-4
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Dioscin is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.
Publictions citing BOC Sciences Products
  • >> More
Collettiside III, Saponin
1.Inhibition of dioscin on Saprolegnia in vitro.
Liu L1, Shen YF1, Liu GL2, Ling F1, Liu XY1, Hu K3, Yang XL3, Wang GX4. FEMS Microbiol Lett. 2015 Dec;362(24):fnv196. doi: 10.1093/femsle/fnv196. Epub 2015 Oct 14.
As one of the most serious pathogens in the freshwater aquatic environment, Saprolegnia can induce a high mortality rate during the fish egg incubation period. This study investigated the anti-Saprolegnia activity of a total of 108 plants on Saprolegnia parasitica in vitro and Dioscorea collettii was selected for further studies. By loading on an open silica gel column and eluting with petroleum ether-ethyl acetate-methanol, dioscin (C45H72O16) was isolated from D. collettii. Saprolegnia parasitica growth was inhibited significantly when dioscin concentration was more than 2.0 mg L(-1). When compared with formalin and hydrogen peroxide, dioscin showed a higher inhibitory effect. As potential inhibition mechanisms, dioscin could cause the S. parasitica mycelium morphologic damage, dense folds, or disheveled protuberances observed by field emission scanning electron microscopy and the influx of Propidium iodide. The structural changes in the treated mycelium were indicative of an efficient anti-Saprolegnia activity of dioscin.
2.Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
Liu M1, Xu Y1, Han X1, Yin L1, Xu L1, Qi Y1, Zhao Y1, Liu K1, Peng J1. Sci Rep. 2015 Dec 10;5:18038. doi: 10.1038/srep18038.
The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo liver fibrosis in mice was induced by an alcoholic liquid diet, and in vitro studies were performed on activated HSC-T6 and LX2 cells treated with lipopolysaccharide. Our results showed that dioscin significantly attenuated hepatic stellate cells (HSCs) activation, improved collagen accumulation, and attenuated inflammation through down-regulating the levels of myeloid differentiation factor 88 (MyD88), nuclear factor κB (NF-κB), interleukin (IL)-1, IL-6 and tumour necrosis factor-α by decreasing Toll-like receptor (TLR)4 expression both in vivo and in vitro. TLR4 overexpression was also decreased by dioscin, leading to the markedly down-regulated levels of MyD88, NF-κB, transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA) and type I collagen (COL1A1) in cultured HSCs. Suppression of cellular MyD88 by ST2825 or abrogation of NF-κB by pyrrolidine dithiocarbamate eliminated the inhibitory effects of dioscin on the levels of TGF-β1, α-SMA and COL1A1.
3.An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
Taketani K1, Hoshino S, Uemura T, Goto T, Takahashi N, Tsuge N, Kawada T. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):465-70. doi: 10.3177/jnsv.61.465.
An efficient purification method for simultaneous recovery of polar saponins, protodioscin (PD) and dioscin (DC), and non-polar aglycon, diosgenin (DG), from plasma of mice fed diets containing seed flours of fenugreek (Trigonella foenum-graecum) was established for subsequent quantitative analysis by LC-ESI-MS/MS. Mice plasma samples were first deproteinated by addition of acetonitrile, and the supernatant was applied to a carbon-based solid phase extraction tube. After successive washing with methanol and 35% chroloform/methanol (v/v), PD, DC and DG were eluted simultaneously with 80% chroloform/methanol (v/v). The eluate was evaporated to dryness, and re-dissolved in 80% methanol (v/v). The filtered sample was analyzed with an LC-ESI-MS/MS system. After the purification procedure, recovery rates between 89.3 to 117.4% were obtained without notable ion suppression or enhancement. The use of internal standards was therefore not necessary.
4.[Preliminary study on hepatotoxicity induced by dioscin and its possible mechanism].
Zhang YX, Wang YG, Ma ZC, Tang XL, Liang QD, Tan HL, Xiao CR, Zhao YH, Gao Y. Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(14):2748-52.
Dioscin has a wide range of biological effects and broad application prospects. However the studies concerning the toxicology and mechanism of dioscin is small. This article is to study the hepatotoxicity of dioscin and the effect of dioscin treatment on expression of aryl hydrocarbon receptor (AhR) mRNA and CYP1A mRNA and protein in HepG2 cells in vitro. Dioscin 0.5-32 µmol · L(-1) exposed to HepG2 cells for 12 h, cell viability was examined by CCK-8 assay and the release rate of lactate dehydrogenase (LDH) was to evaluate cell membrane damage. HepG2 cells morphologic changes were quantified by inverted Microscope, and the effect on production of reactive oxygen species (ROS) was detected by flow cytometry. The mRNA expression of CYP1A and AhR was evaluated by RT-RCR. The protein expression of CYP1A1 was detected by western blot. The cell viability was significantly inhibited after HepG2 cells were exposed to dioscin 0.5-32 µmol · L(-1).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 90-01-7 2-Hydroxybenzyl alcohol

2-Hydroxybenzyl alcohol
(CAS: 90-01-7)

2-Hydroxybenzyl alcohol could be extracted from salix bark. And this is the reason for 2-Hydroxybenzyl alcohol being named "Salicyl alcohol". It is an precursor...

CAS 612530-44-6 PTP1B-IN-1

(CAS: 612530-44-6)

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor.

FCE 26644
(CAS: 154788-16-6)

FCE 26644, also known as PNU-145156E, has been found to be a angiogenesis inhibitor that could have probable effect against solid tumours. It has already been d...

CAS 1345407-05-7 LTX-315

(CAS: 1345407-05-7)

LTX-315, an oncolytic peptide with potent anticancer activity, kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization. LTX-315 inh...

CAS 383907-43-5 NSC 663284

NSC 663284
(CAS: 383907-43-5)

NSC 663284 is a potent, irreversible, cell permeable and mixed competitive Cdc25 dual specificity phosphatases inhibitor (IC50= 0.21 μM), and poorly inhibits ot...

(CAS: 1345982-69-5)

GSK-2330672, an ASBT inhibitor, has been developed for the treatment of type 2 diabetes and is currently under Phase II trail against primary biliary cirrhosis ...

CAS 40246-10-4 Glycitin

(CAS: 40246-10-4)

Glycitin is an isoflavonoid recently found in flowers of Pueraria thunbergianal. It can be modified into the metabolite glycitein which has anti-inflammatory pr...

(CAS: 460741-57-5)

A Metabolite of Pomalidomide.

CH 141
(CAS: 78279-88-6)

CH 141 is a peripheral vasodilator.

CAS 70052-12-9 Eflornithine

(CAS: 70052-12-9)

Eflornithine is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme requ...

CGP 71683 hydrochloride
(CAS: 192322-50-2)

CGP 71683 hydrochloride is a highly selective non-peptide antagonist of the NPY Y(5) receptor (IC50= 1.4 nM) with > 1000-fold selectivity over Y1 (IC50= 2765 nM...

CAS 1953-02-2 Tiopronin

(CAS: 1953-02-2)

Tiopronin is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria by controlling the rate of cystine precipitation and excretio...

CAS 347323-96-0 ITX3

(CAS: 347323-96-0)

ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compou...

CAS 1509-34-8 L-Allo-isoleucine

(CAS: 1509-34-8)

L-Allo-isoleucine, an amino acid compound, has been found to be probably significant in the study of modulating of blood sugar.

CAS 1582-09-8 Trifluralin

(CAS: 1582-09-8)

Trifluralinis a pre-emergence herbicide, because it causes absence of microtubule which leads to prevents the completion of plant cell division. However, it doe...

CAS 1083162-61-1 FIN56

(CAS: 1083162-61-1)

FIN56 is a specific inducer of ferroptosis and causes the loss of GPX4 activity in cell lysates.

Cgp 21833
(CAS: 122378-49-8)

Cgp 21833 has a thiocarbonylamides structure and it is a potent antifilarial agent under laboratory research stage.

(CAS: 171655-92-8)

NS-2214, an azabicyclo compound, has been found to be a dopamine uptake inhibitor that was once studied in the treatment of Parkinson's disease.

(CAS: 1075236-89-3)

Gepotidacin is a potent Type II DNA topoisomerase inhibitor. It is a novel antibacterial drug candidate. It is used for the treatment of gram positive bacterial...

CAS 6199-67-3 Cucurbitacin B

Cucurbitacin B
(CAS: 6199-67-3)

Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of mic...

Chemical Structure

CAS 19057-60-4 Dioscin

Quick Inquiry

Verification code

Featured Items