Dioctanoylglycol - CAS 627-86-1
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Dioctanoylglycol has been found to be a diacylglycerol kinase (DGK) inhibitor.
≥95% by HPLC
Dioctanoyl ethylene glycol; 2-Octanoyloxyethyl octanoate
Canonical SMILES:
1.Regulation of bradykinin-stimulated cation entry into endothelial cells by tyrosine kinase.
Takahashi R;Watanabe H;Kakizawa H;Zhang XX;Hayashi H;Ohno R Jpn Circ J. 1997 Dec;61(12):1030-6.
In endothelial cells, bradykinin stimulates the release of intracellular Ca2+, which is followed by the entry of extracellular Ca2+ into the cells. However, the mechanism underlying the Ca2+ entry is not well understood. To investigate the possible implication of tyrosine kinases in bradykinin-mediated Ca2+ signaling in endothelial cells, cultured porcine aortic endothelial cells were loaded with fura-2/AM, and Mn2+ influx into the cells was determined by the quenching of fluorescence intensity of fura-2 at 360 nm excitation. The tyrosine kinase inhibitors genistein and herbimycin A attenuated not only Ca2+ influx but also Mn2+ influx from the extracellular space without affecting the release of Ca2+ from internal stores in bradykinin-treated cells. In contrast to tyrosine kinase inhibitors, the tyrosine phosphatase inhibitor vanadate stimulated Ca2+ influx as well as Mn2+ influx. On the other hand, both an inactive analog of genistein, daidzein, and an inhibitor of diacylglycerol (DAG) kinase, ethylene glycol dioctanoate, were without effect on [Ca2+]i following the stimulation of agonist. These findings suggest that tyrosine kinase is involved in the regulation of cation influx in endothelial cells.
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CAS 627-86-1 Dioctanoylglycol

(CAS: 627-86-1)

Dioctanoylglycol has been found to be a diacylglycerol kinase (DGK) inhibitor.

Chemical Structure

CAS 627-86-1 Dioctanoylglycol

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