Dimethindene - CAS 5636-83-9
Catalog number:
5636-83-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H24N2
Molecular Weight:
292.42
COA:
Inquire
Targets:
Histamine Receptor
Description:
Dimethindene is a selective histamine H1 antagonist. It binds to the histamine H1 receptor. It is an antiallergic drug and is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies. It is an antihistamine/anticholinergic used orally and locally as an antipruritic. It blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. It has been listed.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
2-(1-(2-(2-Dimethylaminoethyl)inden-3-yl)ethyl)pyridine;Dimethpyrindene;Forhistal;N,N-Dimethyl-2-(3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl)ethanamine;Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-;Z2001;Z-2001;Dimetindeno;Fenistil
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Dimethindene is an antiallergic drug and is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies. It is an antihistamine/anticholinergic used orally and locally as an antipruritic.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
165-175 °C | Condition: Press: 0.5 Torr
Density:
1.065±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MVMQESMQSYOVGV-UHFFFAOYSA-N
InChI:
InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3
Canonical SMILES:
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
Current Developer:
Dimethindene has been listed.
1.A subset of histamine receptor ligands improve thermotolerance of the yeast Saccharomyces cerevisiae.
Papamichael K1, Delitheos B, Tiligada E. J Appl Microbiol. 2013 Feb;114(2):492-501. doi: 10.1111/jam.12055. Epub 2012 Dec 12.
AIMS: Histamine interacts with the stress response in eukaryotes. This study investigated the effects of antihistamines on the heat shock (HS) response in yeast, thereby exploring their functions in a well-established histamine receptor (H(x) R)-free model.
2.Matrix metaloproteinase-2 and -9 serum levels as potential markers of intraperitoneal adhesions.
Christodoulidis G1, Tsilioni I, Spyridakis ME, Kiropoulos T, Oikonomidi S, Koukoulis G, Tepetes K. J Invest Surg. 2013 Jun;26(3):134-40. doi: 10.3109/08941939.2012.730599. Epub 2013 Mar 20.
OBJECTIVE: To assess the value of matrix metalloproteinases-2 (MMP-2) and -9 (MMP-9) as prognostic serum markers for intraperitoneal adhesions.
3.Characterizing the interaction between enantiomers of eight psychoactive drugs and highly sulfated-β-cyclodextrin by counter-current capillary electrophoresis.
Asensi-Bernardi L1, Escuder-Gilabert L, Martín-Biosca Y, Sagrado S, Medina-Hernández MJ. Biomed Chromatogr. 2014 Jan;28(1):120-6. doi: 10.1002/bmc.2935. Epub 2013 Jun 4.
The estimation of apparent binding constants and limit mobilities of the complexes of the enantiomers that characterize the interaction of enantiomers with chiral selectors, in this case highly sulfated β-cyclodextrin, was approached using a simple and economic electrophoretic modality, the complete filling technique (CFT) in counter-current mode. The enantiomers of eight psychoactive drugs, four antihistamines (dimethindene, promethazine, orphenadrine and terfenadine) and four antidepressants (bupropion, fluoxetine, nomifensine and viloxazine) were separated for the first time for this cyclodextrin (CD). Estimations of thermodynamic and electrophoretic enantioselectivies were also performed. Results indicate that, in general, thermodynamic enantioselectivity is the main component explaining the high resolution found, but also one case suggests that electrophoretic enantioselectivity itself is enough to obtain a satisfactory resolution. CFT results advantageous compared with conventional capillary electrophoresis (CE) and partial filling technique (PFT) for the study of the interaction between drugs and chiral selectors.
4.Life of lesions in eosinophilic cellulitis (Wells' syndrome)-a condition that may be missed at first sight.
Peckruhn M1, Tittelbach J, Schliemann S, Elsner P. Am J Dermatopathol. 2015 Feb;37(2):e15-7. doi: 10.1097/DAD.0000000000000051.
Eosinophilic cellulitis is an inflammation of, until now, unknown etiology that was first described by George Wells in 1971. Its dominating histological hallmarks are so-called "flame figures" and an eosinophilic infiltrate. Here, we report the case of a 46-year-old man who initially presented with excoriated papules that were histologically interpreted as consistent with "arthropod reactions." Later on, the clinical presentation changed to erythematous plaques, partially with cockade-like aspects. At this time, new biopsies were performed showing a superficial and deep perivascular lymphocytic and heavily eosinophilic infiltrate and flame figures, thus allowing to establish the diagnosis of Wells' syndrome. Under treatment with oral prednisolone and dapsone, the patient showed a rapid improvement of the condition. The presented case demonstrates both the clinical and histopathologic life of lesions of Well's syndrome in the course of the disease from unspecific to distinctive.
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CAS 5636-83-9 Dimethindene

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