Dimaprit dihydrochloride - CAS 23256-33-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Histamine Receptor
The hydrochloride salt form of Dimaprit, which has been found to be a histamine H2 receptor agonist.
≥99% by HPLC
White Solid
S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Canonical SMILES:
1.In vitro relaxation of dog cerebral veins in response to histamine is mediated by histamine H2 receptors.
Monge L;García-Villalón AL;Fernández N;García JL;Gómez B;Diéguez G Eur J Pharmacol. 1997 Nov 5;338(2):135-41.
There is little information on the histamine receptor mechanisms involved in cerebral venodilation, thus the role of histamine present in human cerebrospinal fluid is difficult to assess. In isolated canine pial veins, concentration-response curves to histamine (10[-7]-10[-3] M), the histamine H1 receptor agonist, 2-pyridylethylamine (10[-6]-10[-2] M), the histamine H2 receptor agonist, dimaprit (S-(3-dimethylaminopropyl) isothiourea dihydrochloride, 10[-6]-10[-2] M), and the histamine H3 receptor agonist, imetit (S-[2-(1 midazol-4-yl)ethyl]isothiourea dihydrobromide, 10[-7]-10[-3] M) were isometrically determined. In resting veins, histamine, 2-pyridylethylamine and dimaprit had no significant effect, whereas in endothelin-1-precontracted veins, these drugs produced concentration-dependent relaxation (Emax in % of active tone and pD2 were: for histamine, 72 +/- 6 and 5.36 +/- 0.09; for 2-pyridylethylamine, 59 +/- 5 and 3.28 +/- 0.05; for dimaprit, 65 +/- 7 and 4.81 +/- 0.10, respectively). The relaxations in response to histamine and dimaprit were competitively antagonized by the histamine H2 receptor antagonist, cimetidine (3 x 10[-6]-10[-4] M) (pA2 = 6.07 +/- 0.03 for histamine, and 6.
2.H2-receptors in the human ocular surface.
Abelson MB;Udell IJ Arch Ophthalmol. 1981 Feb;99(2):302-4.
Ten normal human volunteers participated in a two-part study of H2-receptor activity in the ocular surface. Dimethylaminopropylisothiourea (trivial name, dimaprit dihydrochloride), a highly selective H2-receptor agonist, produced vasodilation without itch. Pretreatment with the H2-receptor antagonist, cimetidine, significantly blocked the vasodilatory effect of dimethylaminopropylisothiourea, whereas pretreatment with the H1-receptor antagonist, antazoline phosphate, did not. We conclude that H2-receptors are present in the human ocular surface.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products

CAS 3964-81-6 Azatadine

(CAS: 3964-81-6)

Azatadine is a new antihistamine acts as histamine for histamine H1- receptor inhibitor ( IC50 = 6.5 nM and 10 nM, respectively).

CAS 100299-08-9 Pemirolast potassium

Pemirolast potassium
(CAS: 100299-08-9)

Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

CAS 16503-22-3 Nα-Methylhistamine dihydrochloride

Nα-Methylhistamine dihydrochloride
(CAS: 16503-22-3)

Nα-Methylhistamine dihydrochloride, a production of Nα-Methylhistamine (NAMH), is a potent histamine agonist, particularly at H3 receptors (potency relative to ...

CAS 1028327-66-3 VUF10460

(CAS: 1028327-66-3)

VUF10460 is a specific non-imidazole histamine H4 receptor agonist (pKi= 7.46, 8.22 for rat H4 receptor and human H4 receptor respectively) with 50-fold selecti...

CAS 100643-71-8 Desloratadine

(CAS: 100643-71-8)

Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.

CAS 99291-25-5 Levodropropizine

(CAS: 99291-25-5)

Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory n...

CAS 147-24-0 Diphenhydramine HCl

Diphenhydramine HCl
(CAS: 147-24-0)

Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a ...

CAS 73903-17-0 JNJ-10191584

(CAS: 73903-17-0)

JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and ana...

Chemical Structure

CAS 23256-33-9 Dimaprit dihydrochloride

Quick Inquiry

Verification code

Featured Items