Diltiazem - CAS 42399-41-7
Catalog number: 42399-41-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Calcium Channel
Diltiazem is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia as a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction.
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Solid powder
Cardizem; D-cis-Diltiazem; [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;
Soluble in DMSO
Store at -20 °C
A nondihydropyridines (non-DHP) calcium channel blocker
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
1.26 g/cm3
Canonical SMILES:
1.Twenty-Four-Hour Urine α1 -Microglobulin as a Marker of Hypertension-Induced Renal Impairment and Its Response on Different Blood Pressure-Lowering Drugs.
Liakos CI1, Vyssoulis GP1, Markou MI1, Kafkas NV2, Toutouzas KP1, Tousoulis D1. J Clin Hypertens (Greenwich). 2016 Mar 18. doi: 10.1111/jch.12811. [Epub ahead of print]
The purpose of this study was to assess the role of urine α1 -microglobulin as a marker of hypertension-induced renal damage compared with estimated glomerular filtration rate, (eGFR), urine albumin, and urine albumin-to-creatinine ratio (ACR). Its response on different blood pressure (BP)-lowering drugs was also studied. Sixty never-treated hypertensive patients (65.0% men, 46.9 years, BP 141.4/94.0 mm Hg) were randomized to an irbesartan (an angiotensin receptor blocker [ARB]) or a diltiazem (a nondihydropyridine calcium channel blocker [CCB])-based regimen. Patients with diabetes or established cardiovascular, renal, or liver disease were excluded. Blood samples and 24-hour urine were analyzed at baseline and 6 months after pharmaceutical BP normalization. Serum creatinine was measured and eGFR was calculated. Urine albumin, creatinine, and α1 -microglobulin were measured and ACR was calculated. Minor changes (P=not significant [NS]) in eGFR were noted during follow-up in both groups (from 111.
2.Predicted and observed therapeutic dose exceedances of ionizable pharmaceuticals in fish plasma from urban coastal systems.
Scott WC1, Du B1, Haddad SP1, Breed CS1, Saari GN1, Kelly M2, Broach L2, Chambliss CK1,3, Brooks BW1. Environ Toxicol Chem. 2016 Apr;35(4):983-95. doi: 10.1002/etc.3236. Epub 2016 Jan 19.
Instream flows of the rapidly urbanizing watersheds and estuaries of the Gulf of Mexico in Texas (USA) are increasingly dominated by reclaimed waters. Though ionizable pharmaceuticals have received increasing attention in freshwaters, many research questions remain unanswered, particularly in tidally influenced urban coastal systems, which experience significant spatiotemporal variability in pH that influences bioavailability and bioaccumulation. The authors coupled fish plasma modeling of therapeutic hazard values with field monitoring of water chemistry variability and pharmaceutical occurrence to examine whether therapeutic hazards to fish existed within these urban coastal ecosystems and whether therapeutic hazards differed within and among coastal locations and seasons. Spatial and temporal fluctuations in pH within study sites altered the probability of encountering pharmaceutical hazards to fish. Significant water quality differences were consistently observed among traditional parameters and pharmaceuticals collected from surface and bottom waters, which are rarely sampled during routine surface water quality assessments.
3.Regression of Calcium Channel Blocker--Induced Gingival Enlargement in the Absence of Periodontal Therapy.
Livada R, Shelton W, Bland PS, Shiloal J. J Tenn Dent Assoc. 2015 Fall-Winter;95(2):11-4; quiz 15-6.
AIM: To illustrate the negative effect of calcium channel blocker (CCB) drugs on the gingival tissues and the reversibility of these lesions.
4.Clinical Experience with Diltiazem in the Treatment of Cardiovascular Diseases.
Rodríguez Padial L1, Barón-Esquivias G2, Hernández Madrid A3, Marzal Martín D4, Pallarés-Carratalá V5,6, de la Sierra A7. Cardiol Ther. 2016 Mar 25. [Epub ahead of print]
Cardiovascular diseases are the leading cause of death in the world. Coronary artery diseases, atrial fibrillation or hypertensive heart disease, are among the most important cardiovascular disorders. Hypertension represents a significant risk factor for cardiovascular mortality; thus, control of high blood pressure has become a priority to prevent major complications. Although the choice of drugs for treating hypertension remains controversial, extensive clinical evidences point to calcium channel blockers as first-line agents. Diltiazem, a non-dihydropyridine calcium channel blocker, is an effective and safe antihypertensive drug, alone or in combination with other agents. Diltiazem lowers myocardial oxygen demand through a reduction in heart rate, blood pressure, and cardiac contractility, representing also a good alternative for the treatment of stable chronic angina. Furthermore, diltiazem reduces conduction in atrioventricular node, which is also useful for heart rate control in patients with atrial fibrillation.
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CAS 42399-41-7 Diltiazem

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