Diloxanide furoate - CAS 3736-81-0
Catalog number:
3736-81-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H11Cl2NO4
Molecular Weight:
328.15
COA:
Inquire
Targets:
Antiparasitic
Description:
Diloxanide furoate is an ambecide used to treat infection with amoebas.
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Purity:
≥95%
Appearance:
White Solid
Synonyms:
Furamide; 4-[(Dichloroacetyl)methylamino]phenyl 2-Furancarboxylic Acid Ester; 2-Furoic Acid Ester with 2,2-Dichloro-4’-hydroxy-N-methylacetanilide;
Solubility:
Soluble in DMSO
Storage:
Store at 2-8 °C
MSDS:
Inquire
Application:
An ambecide, an anti-protozoal drug used in the treatment of amoebozoa infections.
Quality Standard:
Enterprise Standard/EP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
107-110 °C
Density:
1.424 g/cm3
InChIKey:
BDYYDXJSHYEDGB-UHFFFAOYSA-N
InChI:
InChI=1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
Canonical SMILES:
CN(C1=CC=C(C=C1)OC(=O)C2=CC=CO2)C(=O)C(Cl)Cl
1.Synthesis of novel N-(4-benzoylphenyl)-2-furamide derivatives and their pharmacological evaluation as potent antihyperlipidemic agents in rats.
Al-Qirim T1, Shattat G1, Sheikha GA1, Sweidan K2, Al-Hiari Y3, Jarab A1. Drug Res (Stuttg). 2015 Mar;65(3):158-63. doi: 10.1055/s-0034-1375646. Epub 2014 May 21.
In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis and pharmacological activity of a series of novel N-(4-benzoylphenyl)-2-furamides (3a-3e). Hyperlipidemia was induced in rats by single intraperitoneal injection of Triton WR-1339 (300 mg/kg body weight). At a dose of 15 mg/kg body weight, compounds 3b, 3d and bezafibrate (100 mg/kg) significantly (p<0.0001) reduced elevated plasma triglyceride levels after 18 h compared to the hyperlipidemic control group. However, only groups treated with compounds 3b, and 3d obviously showed a significant (p<0.0001) reduction in plasma total cholesterol levels. Moreover, high density lipoprotein-cholesterol levels were significantly (p<0.0001) increased in animals treated with compounds 3b, 3d and bezafibrate. It is therefore reasonable to assume that compounds 3b and 3d may have promising potential in the treatment of hyperlipidemia. This beneficial activity may contribute to their cardioprotective and antiatherosclerotic role.
2.Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.
Abdelaleem EA1, Abdelwahab NS. Pak J Pharm Sci. 2013 Jan;26(1):175-83.
This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetrol® tablets - spectrophotometric and RP-HPLC methods using UV detection. The developed spectrophotometric methods depend on determination of MEH and DF in the combined dosage form using the successive derivative ratio spectra method which depends on derivatization of the obtained ratio spectra in two steps using methanol as a solvent and measuring MEH at 226.4-232.2 nm (peak to peak) and DF at 260.6-264.8 nm (peak to peak). While MET concentrations were determined using first derivative (1D) at λ = 327 nm using the same solvent. The chromatographic method depends on HPLC separation on ODS column and elution with a mobile phase consisting water: methanol: triethylamine (25: 75: 0.5, by volume, orthophosphoric acid to pH =4). Pumping the mobile phase at 0.
3.Branch portal vein pyaemia secondary to amoebic liver abscess.
Kenny C1, Sohan O1, Murray L1, Fox TP1. BMJ Case Rep. 2015 Jun 8;2015. pii: bcr2014209098. doi: 10.1136/bcr-2014-209098.
We describe a case of a young returning traveller who contracted amoebic dysentery while visiting India. She presented to a major London Hospital several months later with features suggestive of amoebic liver abscesses, a known sequelae of amoebiasis. MRI with intravenous contrast demonstrated an area of likely occlusion of the portal vein. The patient was treated with intravenous metronidazole for 10 days followed by diloxanide furoate, an intraluminal agent. The largest abscess was drained acutely under ultrasound guidance. The portal vein occlusion was treated medically without the use of anticoagulation. A repeat ultrasound at 6 weeks post-treatment confirmed patency of the portal vein indicating spontaneous recanalisation with antimicrobial therapy alone.
4.Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients.
Nagel R1, Bielefeldt-Ohmann H2, Traub R3. Gut Pathog. 2014 Aug 20;6:34. doi: 10.1186/s13099-014-0034-0. eCollection 2014.
BACKGROUND: Blastocystis species are common human enteric parasites. Carriage has been linked to Irritable Bowel Syndrome (IBS). Treatment of Blastocystis spp. with antimicrobials is problematic and insensitive diagnostic methods and re-infection complicate assessment of eradication. We investigated whether triple antibiotic therapy comprising diloxanide furoate, trimethoprim/sulfamethoxazole and secnidazole (TAB) given to diarrhoea-predominant IBS (D-IBS) patients positive for Blastocystis would achieve eradication.
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Chemical Structure

CAS 3736-81-0 Diloxanide furoate

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